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Sceleratine
Sceleratine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Sceleratine
Price:
CAS No.: 6190-25-6
Catalog No.: CFN00414
Molecular Formula: C18H27NO7
Molecular Weight: 369.41 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Senecio latifolius DC.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: Sceleratine is a natural product from Senecio latifolius DC.
Sceleratine Description
Source: The herbs of Senecio latifolius DC.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.707 mL 13.5351 mL 27.0702 mL 54.1404 mL 67.6755 mL
5 mM 0.5414 mL 2.707 mL 5.414 mL 10.8281 mL 13.5351 mL
10 mM 0.2707 mL 1.3535 mL 2.707 mL 5.414 mL 6.7675 mL
50 mM 0.0541 mL 0.2707 mL 0.5414 mL 1.0828 mL 1.3535 mL
100 mM 0.0271 mL 0.1354 mL 0.2707 mL 0.5414 mL 0.6768 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Tetrahedron Letters,1985, 26(46):5721–5724.
A new pyrrolizidine alkaloid N-oxide and the revised structure of sceleratine[Reference: WebLink]
Sceleratine [1] and its N-oxide [2] have been isolated from Senecio latifolius DC and their structures determined by spectroscopic and chemical methods and X-ray crystallography.
CFN00423Senecivernine72755-25-0335.40C18H25NO5
CFN00472Senecivernine N-oxide101687-28-9351.4C18H25NO6
CFN00360Cronaburmine71295-32-4323.39C17H25NO5
CFN00366Crotananine71295-28-8323.39C17H25NO5
CFN00372Grantianine633-10-3365.38C18H23NO7
CFN00387Nemorensine50906-96-2337.41C18H27NO5
CFN00406Pterophorine62786-99-6389.40C20H23NO7
CFN00410Retusamine6883-16-5379.41C19H25NO7
CFN00414Sceleratine6190-25-6369.41C18H27NO7
CFN00471Sceleratine N-oxide103184-92-5385.4C18H27NO8
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