Senaetnine | CAS:64191-69-1 | Manufacturer ChemFaces

Senaetnine

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Description:

Senaetnine possesses mild alkylating reactivity, and the evidence indicates that it can cause moderate tissue injury without the need for metabolic activation.

In vivo:

Toxicol Lett. 1987 Oct;38(3):315-9.

Toxic actions of senaetnine, a new pyrrolizidine-type alkaloid, in rats.[Pubmed: 3660434 ]

Senaetnine is a new type of Senecio alkaloid with a dihydropyrrolizinone structure.
METHODS AND RESULTS:
A limited amount of the crude alkaloid was available for preliminary toxicity tests in weanling male rats via i.p., oral and i.v. routes. Single i.p. or p.o. doses up to 280 mg/kg were not acutely toxic, and showed no evidence of hepatotoxicity. The compound or its metabolites appeared to be eliminated rapidly via the kidneys. However, Senaetnine had a direct irritant action on tissues near to the site of i.p. administration, and caused damage to pulmonary vascular tissue when given i.v. Senaetnine is closely related to, but less reactive than, dehydrosenecionine, a putative short-lived metabolite of the alkaloid senecionine.
CONCLUSIONS:
It possesses mild alkylating reactivity, and the evidence indicates that it can cause moderate tissue injury without the need for metabolic activation. This suggests the need for testing of this and related compounds for chronic toxicity and carcinogenicity.

Senaetnine Description

Source:	The herbs of Senecio scandens
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Senaetnine
Price:
CAS No.:	64191-69-1
Catalog No.:	CFN00415
Molecular Formula:	C₂₀H₂₃NO₇
Molecular Weight:	389.40 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Senecio scandens
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Toxicity Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.5681 mL	12.8403 mL	25.6805 mL	51.3611 mL	64.2013 mL
5 mM	0.5136 mL	2.5681 mL	5.1361 mL	10.2722 mL	12.8403 mL
10 mM	0.2568 mL	1.284 mL	2.5681 mL	5.1361 mL	6.4201 mL
50 mM	0.0514 mL	0.2568 mL	0.5136 mL	1.0272 mL	1.284 mL
100 mM	0.0257 mL	0.1284 mL	0.2568 mL	0.5136 mL	0.642 mL

CFN00388	Nilgirine	21009-05-2	321.37	C₁₇H₂₃NO₅
CFN00389	Crotastriatine	11051-94-8	363.41	C₁₉H₂₅NO₆
CFN00403	Platyphylline	480-78-4	337.41	C₁₈H₂₇NO₅
CFN00404	Hygrophylline	3573-82-8	353.41	C₁₈H₂₇NO₆
CFN00405	Ligularinine	90364-90-2	337.41	C₁₈H₂₇NO₅
CFN00407	Retrorsine	480-54-6	351.40	C₁₈H₂₅NO₆
CFN00409	Usaramine	15503-87-4	351.40	C₁₈H₂₅NO₆
CFN00473	Usaramine N-oxide	117020-54-9	367.4	C₁₈H₂₅NO₇
CFN00412	Rosmarinine	520-65-0	353.41	C₁₈H₂₇NO₆
CFN00413	12-O-Acetylrosmarinine	137760-53-3	395.45	C₂₀H₂₉NO₇