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Solanesol
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Product Name Solanesol
Price: $30 / 20mg
CAS No.: 13190-97-1
Catalog No.: CFN90454
Molecular Formula: C45H74O
Molecular Weight: 631.07 g/mol
Purity: >=98%
Type of Compound: Miscellaneous
Physical Desc.: Powder
Source: The herbs of Nicotiana tabacum L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Solanesol can effectively scavenge lipid radicals to block lipid peroxidation, and inhibit effects on tyrosinase; it also can protect ethanol-induced L02 cell damage, which might be attributed to the activation of HO-1 and Hsp70.
Targets: HSP (e.g. HSP90) | HO-1 | Caspase | PARP
In vitro:
Toxicol In Vitro. 2015 Apr;29(3):600-8.
Solanesol protects human hepatic L02 cells from ethanol-induced oxidative injury via upregulation of HO-1 and Hsp70.[Pubmed: 25645596]

METHODS AND RESULTS:
In present study, we showed that the mRNA and protein levels of HO-1 and Hsp70 in Solanesol-treated L02 cells were significantly increased. The induction of the HO-1 by Solanesol is majorly achieved via enhancing the nuclear translocation and transactivity of Nrf2 through enhancement of Hsp90-Keap1 interaction, while Solanesol-elevated Hsp70 is related with promoting the nuclear translocation of HSF1 through the involvement of chaperones interaction. Furthermore, the induction of HO-1 and Hsp70 by Solanesol could protect against ethanol-induced liver injury, including significantly suppressing the elevation of the activities of LDH and AST, attenuating ethanol-induced increase of the MDA, ROS level and decrease of the GSH level. Moreover, Solanesol also suppressed ethanol-induced apoptosis of L02 cells by inhibition of nuclear morphological damage, procaspase 3 and cleavage of caspase 3 and PARP, suggesting Solanesol may be beneficial against ALD. Solanesol also promoted tBHQ-mediated protective effects. However, treatment cells with SnPP or PES markedly abrogated the protective effects of Solanesol on ethanol-induced cell injury.
CONCLUSIONS:
These results strongly suggested that Solanesol could protect ethanol-induced L02 cell damage, which might be attributed to the activation of HO-1 and Hsp70.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2014 Aug;31(4):833-6, 841.
Antioxidant function of solanesol and its inhibitory effect on tyrosinase[Pubmed: 25464797]
The present paper intends to discuss the antioxidant and tyrosinase inhibition effect of Solanesol from three aspects of ultraviolet radiation and free radical scavenging.
METHODS AND RESULTS:
The paper makes a survey on diurnal variation rule of the minimum ultraviolet transmittance and ultraviolet transmittance of Solanesol, hydroxyl (OH) free radical scavenging method of Smirnoff reaction system model, superoxide anion O2- free radical scavenging method of pyrogallol autoxidation, and the inhibitory effect of Solanesol on tyrosinase activity by enzyme kinetic method. The experiment results showed that Solanesol could effectively scavenge lipid radicals to block lipid peroxidation, and inhibit effects on tyrosinase.
METHODS AND RESULTS:
Solanesol is a natural extract which could be used to prevent senile atrophy of human skin and senile plaque.
Biomolecules . 2019 Aug 2;9(8):334.
Bioactivities and Medicinal Value of Solanesol and Its Accumulation, Extraction Technology, and Determination Methods[Pubmed: 31382471]
Abstract Solanesol, an aliphatic terpene alcohol composed of nine isoprene units, is mainly found in solanaceous plants. Particularly, tobacco (Nicotiana tabacum), belonging to the Solanaceae family, is the richest plant source of Solanesol, and its leaves have been regarded as the ideal material for Solanesol extraction. Since the discovery of Solanesol in tobacco, significant progress has been achieved in research on Solanesol's bioactivities, medicinal value, accumulation, extraction technology, and determination methods. Solanesol possesses strong free radical absorption ability and antioxidant activity owing to the presence of several non-conjugated double bonds. Notably, Solanesol's anti-inflammatory, neuroprotective, and antimicrobial activities have been previously demonstrated. Solanesol is a key intermediate in the synthesis of coenzyme Q10, vitamin K2, and the anticancer agent synergiser N-solanesyl-N,N'-bis(3,4-dimethoxybenzyl) ethylenediamine. Other applications of Solanesol include Solanesol derivative micelles for hydrophobic drug delivery, Solanesol-derived scaffolds for bioactive peptide multimerization, and Solanesol-anchored DNA for mediating vesicle fusion. Solanesol accumulation in plants is influenced by genetic and environmental factors, including biotic stresses caused by pathogen infections, temperature, illumination, and agronomic measures. Seven extraction technologies and seven determination methods of Solanesol are also systematically summarized in the present review. This review can serve as a reference for Solanesol's comprehensive application. Keywords: accumulation; bioactivity; determination methods; extraction technology; medicinal value; Solanesol.
Solanesol Description
Source: The herbs of Nicotiana tabacum L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Cell. 2018 Jan 11;172(1-2):249-261.e12.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.5846 mL 7.9231 mL 15.8461 mL 31.6922 mL 39.6153 mL
5 mM 0.3169 mL 1.5846 mL 3.1692 mL 6.3384 mL 7.9231 mL
10 mM 0.1585 mL 0.7923 mL 1.5846 mL 3.1692 mL 3.9615 mL
50 mM 0.0317 mL 0.1585 mL 0.3169 mL 0.6338 mL 0.7923 mL
100 mM 0.0158 mL 0.0792 mL 0.1585 mL 0.3169 mL 0.3962 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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