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Tinospinoside C
Tinospinoside C
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Tinospinoside C
Price:
CAS No.: 1383977-51-2
Catalog No.: CFN96616
Molecular Formula: C27H36O12
Molecular Weight: 552.58 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The roots of Tinospora sagittata (Oliv.) Gagnep.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Tinospinoside C shows inhibitory activities of NO production with the IC(50) value of 218 uM.
Targets: NO
In vitro:
Planta Med. 2012 Jan;78(1):82-5
Clerodane diterpenoids from Tinospora sagittata (Oliv.) Gagnep.[Pubmed: 21969117 ]

METHODS AND RESULTS:
Three new clerodane diterpene glycosides, tinospinosides A (1), B (2), and C (3) were isolated from the roots of Tinospora sagittata (Oliv.) Gagnep. Their structures were determined to be (2 S,4a R,6a R,9 R,10a S,10b S)-2-(3-furanyl)-9-( β-D-glucopyranosyloxy)-1,4,4a,5,6,6a,9,10,10a,10b-decahydro-6a,10b-dimethyl-4-oxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester (1), (2 S,4a S,6a R,9 R,10a R,10b S)-2-(3-furanyl)-9-( β-D-glucopyranosyloxy)-1,4,4a,5,6,6a,9,10,10a,10b-decahydro-4a-hydroxyl-6a,10b-dimethyl-4-oxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester (2) and (2 S,4a R,6a R,9 R,10a R,10b S)-2-(3-furanyl)-9-( β-D-glucopyranosyloxy)-1,4,4a,5,6,6a,9,10,10a,10b-decahydro-4a-hydroxyl-6a,10b-dimethyl-4-oxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester (3), by various spectroscopic analyses, chemical reactions, and computer-assisted calculations. The inhibitory activities of NO production by these compounds and their chemical derivatives in lipopolysaccharide and TNF γ-activated macrophage-like cell line J774.1 were tested.
CONCLUSIONS:
Tinospin A, 12- EPI-tinospin A, tinospinoside B, and Tinospinoside C showed inhibitory activities of NO production with the IC(50) values of 162, 182, 290, and 218 μM, respectively.
Tinospinoside C Description
Source: The roots of Tinospora sagittata (Oliv.) Gagnep.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.8097 mL 9.0485 mL 18.0969 mL 36.1939 mL 45.2423 mL
5 mM 0.3619 mL 1.8097 mL 3.6194 mL 7.2388 mL 9.0485 mL
10 mM 0.181 mL 0.9048 mL 1.8097 mL 3.6194 mL 4.5242 mL
50 mM 0.0362 mL 0.181 mL 0.3619 mL 0.7239 mL 0.9048 mL
100 mM 0.0181 mL 0.0905 mL 0.181 mL 0.3619 mL 0.4524 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Planta Med. 2014 Mar;80(5):419-25.
New clerodane diterpenes from Tinospora sagittata var. yunnanensis.[Pubmed: 24634023]

METHODS AND RESULTS:
Four new clerodane diterpenes, namely sagittatayunnanosides A-D (1-4), were isolated from the roots of Tinospora sagittata var. yunnanensis, together with two known compounds, Tinospinoside C (5) and tinospinoside E (6).
CONCLUSIONS:
The structures of the four new compounds were well elucidated by extensive analyses of the MS, IR, and 1D and 2D NMR data. The cytotoxic and antifouling activities of compounds 1-6 were evaluated.
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