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Yadanziolide B
Yadanziolide B
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Yadanziolide B
Price:
CAS No.: 95258-13-2
Catalog No.: CFN96427
Molecular Formula: C20H26O11
Molecular Weight: 442.41 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The seeds of Brucea javanica.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Yadanziolide B exhibits cytotoxic activities with IC50 values of 3.00-5.81 uM.
Yadanziolide B Description
Source: The seeds of Brucea javanica.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.2603 mL 11.3017 mL 22.6035 mL 45.2069 mL 56.5087 mL
5 mM 0.4521 mL 2.2603 mL 4.5207 mL 9.0414 mL 11.3017 mL
10 mM 0.226 mL 1.1302 mL 2.2603 mL 4.5207 mL 5.6509 mL
50 mM 0.0452 mL 0.226 mL 0.4521 mL 0.9041 mL 1.1302 mL
100 mM 0.0226 mL 0.113 mL 0.226 mL 0.4521 mL 0.5651 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J Nat Prod. 2011 Nov 28;74(11):2438-45.
Indole alkaloids and quassinoids from the stems of Brucea mollis.[Pubmed: 22070654]

METHODS AND RESULTS:
Seven new indole alkaloids, bruceollines H-N (1-7), three new quassinoids, yadanziolides T-V (10-12), and four known analogues, bruceolline E (8), bruceolline F (9), bruceine D (13), and Yadanziolide B (14), were isolated from an ethanol extract of the stems of Brucea mollis.
CONCLUSIONS:
The absolute configurations of compounds 2 and 5 were determined by comparison of their experimental and calculated ECD spectra. The absolute configuration of the known compound 9 was determined by using Mo2(OAc)4-induced CD analysis for the first time. Compounds 10, 13, and 14 exhibited cytotoxic activities with IC50 values of 3.00-5.81 μM.
Chemical & Pharmaceutical Bulletin, 1984 , 32 (11) :4698-701.
Structures of yadanziolides A, B, and C, new bitter principles from Brucea javanica.[Reference: WebLink]
Three bitter quassinoids, yadanziolide A, Yadanziolide B, and yadanziolide C (1, 2 and 3), were isolated from seeds of Brucea javanica, known as"Ya-dan-zi" in Chinese folklore and their structures have been established from chemical transformation and spectral analysis.
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Prunasin

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Velutin

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Price: $/mg
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