| Structure Identification: |
| J Nat Prod. 2011 Nov 28;74(11):2438-45. | | Indole alkaloids and quassinoids from the stems of Brucea mollis.[Pubmed: 22070654] |
METHODS AND RESULTS:
Seven new indole alkaloids, bruceollines H-N (1-7), three new quassinoids, yadanziolides T-V (10-12), and four known analogues, bruceolline E (8), bruceolline F (9), bruceine D (13), and Yadanziolide B (14), were isolated from an ethanol extract of the stems of Brucea mollis.
CONCLUSIONS:
The absolute configurations of compounds 2 and 5 were determined by comparison of their experimental and calculated ECD spectra.
The absolute configuration of the known compound 9 was determined by using Mo2(OAc)4-induced CD analysis for the first time. Compounds 10, 13, and 14 exhibited cytotoxic activities with IC50 values of 3.00-5.81 μM. | | Chemical & Pharmaceutical Bulletin, 1984 , 32 (11) :4698-701. | | Structures of yadanziolides A, B, and C, new bitter principles from Brucea javanica.[Reference: WebLink] | | Three bitter quassinoids, yadanziolide A, Yadanziolide B, and yadanziolide C (1, 2 and 3), were isolated from seeds of Brucea javanica, known as"Ya-dan-zi" in Chinese folklore and their structures have been established from chemical transformation and spectral analysis. |
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