Structure Identification: |
Zhong Yao Cai. 2014 Mar;37(3):424-7. | Chemical constituents against hepatic fibrosis from Phyllodium pulchellum roots.[Pubmed: 25174106] | To investigate the bioactive constituents against hepatic fibrosis from the roots of Phyllodium pulchellum.
METHODS AND RESULTS:
The chemical constituents of Phyllodium pulchellum roots were obtained by various chromatographic technologies and identified by several spectroscopic methods.
Ten compounds were elucidated as 3,5,2',4'-tetrahydroxy-2",2"-dimethylpyrano-[5",6",7,8] -flavanone (1), Yukovanol (2), citflavanone (3), 8-prenylated 5,7,3',4'-tetrahydroxyflavanone (4), pulchelstyrene A (5), pulchelstyrene B (6), pulchelstyrene D (7), 3-indolcarbaldehyde (8), 3-methoxyindole (9) and p-hydroxybenzoic acid (10). The effects to inhibit the proliferation of activated HSC-T6 cells of all isolated compounds were also evaluated.
CONCLUSIONS:
All compounds are isolated from this plant for the first time except for compounds 5 - 7. Compounds 2,4,5 and 6 can inhibit the proliferation of activated HSC-T6 cells in vitro. |
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