alpha-Chaconine | CAS:20562-03-2 | Manufacturer ChemFaces

alpha-Chaconine

ChemFaces products have been cited in many studies from excellent and top scientific journals

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Our products had been exported to the following research institutions and universities, And still growing.

National Cancer Center Research... (Japan)
Universidad de Buenos Aires (Argentina)
Florida International University (USA)
St. Jude Children Research Hosp... (USA)

University of Zurich (Switzerland)
Medical University of South Car... (USA)
Tohoku University (Japan)
University of Hawaii Cancer Center (USA)

Donald Danforth Plant Science C... (USA)
Colorado State University (USA)
Gyeongsang National University (Korea)
More...

Package

Featured Products

More...

Gentisic acid

Catalog No: CFN92451
CAS No: 490-79-9
Price: $40/20mg

(-)-Pinoresinol

Catalog No: CFN92287
CAS No: 81446-29-9
Price: $268/5mg

Narirutin

Catalog No: CFN99543
CAS No: 14259-46-2
Price: $80/20mg

Cyclo(Pro-Val)

Catalog No: CFN90275
CAS No: 5654-87-5
Price: $238/10mg

Eriodictyol

Catalog No: CFN99719
CAS No: 552-58-9
Price: $128/20mg

Gancaonin N

Catalog No: CFN95066
CAS No: 129145-52-4
Price: $463/5mg

(+)-Pteryxin

Catalog No: CFN92559
CAS No: 13161-75-6
Price: $188/20mg

Hederacoside C

Catalog No: CFN90183
CAS No: 14216-03-6
Price: $40/20mg

Ascorbic acid

Catalog No: CFN90048
CAS No: 50-81-7
Price: $30/20mg

Prunin

Catalog No: CFN98878
CAS No: 529-55-5
Price: $318/20mg

Description:

Alpha-Chaconine has anti-inflammatory effect, associated with the suppression of AP-1, and supports its possible therapeutic role for the treatment of sepsis. Alpha-Chaconine also has cytotoxic effects.

Targets:

COX | AP-1 | IL Receptor | TNF-α | TGF-β/Smad | JNK | NADPH-oxidase

In vitro:

Food Chem. 2013 Nov 15;141(2):669-74.

Synergistic cytotoxicity induced by α-solanine and α-chaconine.[Pubmed: 23790833]

α-Solanine and alpha-Chaconine are well-known potato toxins, but the mechanism of the synergistic cytotoxic effect of these alkaloids has been little clarified.
METHODS AND RESULTS:
This study confirmed their synergistic cytotoxic effects on C6 rat glioma cells by three different cell viability tests, namely WST-1 (water-soluble tetrazolium) assay sensitive to intracellular NADH concentration, menadione-catalysed chemiluminescent assay depending on both NAD(P)H concentration and NAD(P)H:quinone reductase activity, and LDH (lactate dehydrogenase) assay sensitive to the release of LDH from damaged cells. The maximum cytotoxic effect was observed at a ratio of 1:1 between α-solanine and alpha-Chaconine at micromolar concentrations.
CONCLUSIONS:
The cytotoxic effects of these alkaloids were observed immediately after incubation and were constant after 30min, suggesting that rapid damage of plasma membrane causes the lethal disorder of metabolism.

In vivo:

Chem Biol Interact . 2015 Jun 25;235:85-94.

α-Chaconine isolated from a Solanum tuberosum L. cv Jayoung suppresses lipopolysaccharide-induced pro-inflammatory mediators via AP-1 inactivation in RAW 264.7 macrophages and protects mice from endotoxin shock[Pubmed: 25913072]

Abstract In this study, we investigated the molecular mechanisms underlying the anti-inflammatory effects of α-chaconine in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages and in LPS-induced septic mice. α-Chaconine inhibited the expressions of cyclooxygenase-2 (COX-2), interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α) at the transcriptional level, and attenuated the transcriptional activity of activator protein-1 (AP-1) by reducing the translocation and phosphorylation of c-Jun. α-Chaconine also suppressed the phosphorylation of TGF-β-activated kinase-1 (TAK1), which lies upstream of mitogen-activated protein kinase kinase 7 (MKK7)/Jun N-terminal kinase (JNK) signaling. JNK knockdown using siRNA prevented the α-chaconine-mediated inhibition of pro-inflammatory mediators. In a sepsis model, pretreatment with α-chaconine reduced the LPS-induced lethality and the mRNA and production levels of pro-inflammatory mediators by inhibiting c-Jun activation. These results suggest that the anti-inflammatory effects of α-chaconine are associated with the suppression of AP-1, and support its possible therapeutic role for the treatment of sepsis. Keywords: AP-1; Inflammatory mediators; MKK7; Sepsis; α-Chaconine.

alpha-Chaconine Description

Source:	The peels of Solanum tuberosum
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Chem Biol Interact. 2015 Jun 25;235:85-94.

In this study, we investigated the molecular mechanisms underlying the anti-inflammatory effects of alpha-Chaconine in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages and in LPS-induced septic mice.
METHODS AND RESULTS:
alpha-Chaconine inhibited the expressions of cyclooxygenase-2 (COX-2), interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α) at the transcriptional level, and attenuated the transcriptional activity of activator protein-1 (AP-1) by reducing the translocation and phosphorylation of c-Jun. alpha-Chaconine also suppressed the phosphorylation of TGF-β-activated kinase-1 (TAK1), which lies upstream of mitogen-activated protein kinase kinase 7 (MKK7)/Jun N-terminal kinase (JNK) signaling. JNK knockdown using siRNA prevented the alpha-Chaconine -mediated inhibition of pro-inflammatory mediators. In a sepsis model, pretreatment with alpha-Chaconine reduced the LPS-induced lethality and the mRNA and production levels of pro-inflammatory mediators by inhibiting c-Jun activation.
CONCLUSIONS:
These results suggest that the anti-inflammatory effects of alpha-Chaconine are associated with the suppression of AP-1, and support its possible therapeutic role for the treatment of sepsis.

Product Name	alpha-Chaconine
Price:
CAS No.:	20562-03-2
Catalog No.:	CFN00450
Molecular Formula:	C₄₅H₇₃NO₁₄
Molecular Weight:	852.06 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The peels of Solanum tuberosum
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Antiangiogenic Compound Library Nematicidal Compound Library Genotoxicity Compound Library Alkaloids Compound Library TNF-α Inhibitor Library TGF-β/Smad Inhibitor Library NADPH-oxidase Inhibitor Library JNK Inhibitor Library IL Receptor Inhibitor Library COX Inhibitor Library AP-1 Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.1736 mL	5.8681 mL	11.7363 mL	23.4725 mL	29.3407 mL
5 mM	0.2347 mL	1.1736 mL	2.3473 mL	4.6945 mL	5.8681 mL
10 mM	0.1174 mL	0.5868 mL	1.1736 mL	2.3473 mL	2.9341 mL
50 mM	0.0235 mL	0.1174 mL	0.2347 mL	0.4695 mL	0.5868 mL
100 mM	0.0117 mL	0.0587 mL	0.1174 mL	0.2347 mL	0.2934 mL

CFN90156	Solasonine	19121-58-5	884.06	C₄₅H₇₃NO₁₆
CFN90159	Solamargine	20311-51-7	868.06	C₄₅H₇₃NO₁₅
CFN90387	Khasianine	32449-98-2	721.93	C₃₉H₆₃NO₁₁
CFN90552	Beta-Solamarine	3671-38-3	868.07	C₄₅H₇₃NO₁₅
CFN90553	Solasurine	27028-76-8	721.92	C₃₉H₆₃NO₁₁
CFN93102	Solamarine	20318-30-3	884.1	C₄₅H₇₃NO₁₆
CFN90930	Tomatine	17406-45-0	1034.2	C₅₀H₈₃NO₂₁
CFN70371	Demissidine	474-08-8	399.7	C₂₇H₄₅NO
CFN70454	Solanidine	80-78-4	397.6	C₂₇H₄₃NO
CFN00450	alpha-Chaconine	20562-03-2	852.06	C₄₅H₇₃NO₁₄