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(25R)-Spirost-4-ene-3,12-dione
(25R)-Spirost-4-ene-3,12-dione
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name (25R)-Spirost-4-ene-3,12-dione
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CAS No.: 6875-60-1
Catalog No.: CFN91702
Molecular Formula: C27H38O4
Molecular Weight: 426.6 g/mol
Purity: >=98%
Type of Compound: Steroids
Physical Desc.: Powder
Source: The herbs of Tribulus terrestris L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: (25R)-Spirost-4-ene-3,12-dione has anti-inflammatory and anti-allergic properties. (25R)-Spirost-4-ene-3,12-dione ((-)-(25R)-Spirost-4-ene-3,12-dione) is a natural product that has an inhibitory effect on neutrophil superoxide anion production and histamine release from mast cells
(25R)-Spirost-4-ene-3,12-dione Description
Source: The herbs of Tribulus terrestris L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3441 mL 11.7206 mL 23.4412 mL 46.8823 mL 58.6029 mL
5 mM 0.4688 mL 2.3441 mL 4.6882 mL 9.3765 mL 11.7206 mL
10 mM 0.2344 mL 1.1721 mL 2.3441 mL 4.6882 mL 5.8603 mL
50 mM 0.0469 mL 0.2344 mL 0.4688 mL 0.9376 mL 1.1721 mL
100 mM 0.0234 mL 0.1172 mL 0.2344 mL 0.4688 mL 0.586 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Phytochemistry. 1998 Nov;49(6):1663-1666.
Constituents and bioactive principles of Polygonum chinensis[Pubmed: 9862141]
Isolation and characterization of the chemical constituents of Polygonum chinensis L. gave the new 25R-spirost-4-ene-3,12-dione. The known compounds stigmast-4-ene-3,6-dione, stigmastane-3,6-dione, hecogenin and aurantiamide acetate were also isolated from for the first time from this species. Their anti-inflammatory and anti-allergic properties are described.
CFN99779Sarsasapogenin126-19-2416.64C27H44O3
CFN98501Tigogenin77-60-1416.64C27H44O3
CFN91164Tigogenin acetate2530-07-6458.7C29H46O4
CFN99515Diosgenin512-04-9414.63C27H42O3
CFN90706Pennogenin507-89-1430.62C27H42O4
CFN98586Hecogenin467-55-0430.62C27H42O4
CFN91702(25R)-Spirost-4-ene-3,12-dione6875-60-1426.6C27H38O4
CFN93779Gitogenin511-96-6432.6C27H44O4
CFN91558Chlorogenin562-34-5432.6C27H44O4
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