Apiosylskimmin | CAS:103529-94-8 | Manufacturer ChemFaces

Apiosylskimmin

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Size /Price /Stock	10 mM * 1 mL in DMSO / $413.4 / In-stock
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Description:

Apiosylskimmin is a natural product from Angelica gigas.

In vitro:

Immunopharmacol Immunotoxicol. 2011 Dec;33(4):663-6.

Antiplasmodial and cytotoxic activity of coumarin derivatives from dried roots of Angelica gigas Nakai in vitro.[Pubmed: 21428713]

The butanol-soluble fraction of the dried root of Angelica gigas exhibited significant protection against chloroquine-sensitive strains of Plasmodium falciparum using the parasite lactate dehydrogenase assay method.
METHODS AND RESULTS:
Using antiplasmodial activity-guided fractionation, five coumarins, marmesinin (1), nodakenin (2), skimmin (3), Apiosylskimmin (4), and magnolioside (5), were isolated and evaluated for in vitro antiplasmodial activity, as well as for their cytotoxic potential on SK-OV-3 cancer cell lines. Compounds 1 and 5 showed notable growth inhibitory activity against chloroquine-sensitive strains of P. falciparum with IC(50) values of 5.3 and 8.2 μM. The compounds showed no significant cytotoxicity (IC(50) > 100 μM) toward the SK-OV-3 cancer cell line.
CONCLUSIONS:
This is the first report on the antiplasmodial activity of these coumarin derivatives from the dried root of A. gigas.

Apiosylskimmin Description

Source:	The roots of Peucedanum praeruptorum
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Apiosylskimmin
Price:	$656 / 10mg
CAS No.:	103529-94-8
Catalog No.:	CFN90311
Molecular Formula:	C₂₀H₂₄O₁₂
Molecular Weight:	456.40 g/mol
Purity:	>=98%
Type of Compound:	Coumarins
Physical Desc.:	Powder
Source:	The roots of Peucedanum praeruptorum
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Coumarins Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1911 mL	10.9553 mL	21.9106 mL	43.8212 mL	54.7765 mL
5 mM	0.4382 mL	2.1911 mL	4.3821 mL	8.7642 mL	10.9553 mL
10 mM	0.2191 mL	1.0955 mL	2.1911 mL	4.3821 mL	5.4777 mL
50 mM	0.0438 mL	0.2191 mL	0.4382 mL	0.8764 mL	1.0955 mL
100 mM	0.0219 mL	0.1096 mL	0.2191 mL	0.4382 mL	0.5478 mL

CFN99552	Coumarin	91-64-5	146.15	C₉H₆O₂
CFN96597	6-Methylcoumarin	92-48-8	160.17	C₁₀H₈O₂
CFN91113	7-Methylcoumarin	2445-83-2	160.17	C₁₀H₈O₂
CFN97503	Umbelliferone	93-35-6	162.1	C₉H₆O₃
CFN90566	7-Methoxycoumarin	531-59-9	176.2	C₁₀H₈O₃
CFN90567	7-Ethoxycoumarin	31005-02-4	190.2	C₁₁H₁₀O₃
CFN90419	4-Hydroxycoumarin	1076-38-6	162.14	C₉H₆O₃
CFN94403	4-Methoxycoumarine	20280-81-3	176.17	C₁₀H₈O₃
CFN97505	Skimmin	93-39-0	324.3	C₁₅H₁₆O₈
CFN90311	Apiosylskimmin	103529-94-8	456.40	C₂₀H₂₄O₁₂