CHIR-99021 (CT99021) | CAS:252917-06-9

CHIR-99021 (CT99021)

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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CHIR-99021 (CT99021) Description

Source:
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Cell Research:

Diabetes,2003 Mar;52(3):588-95.

Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo.[Pubmed: 12606497]

Cell lines:Insulin receptor–expressing CHO-IR cells; Primary rat hepatocytes
Concentrations: 0.01-10 μM
Incubation Time: 30 min
Method:
CHO-IR cells expressing human insulin receptor are grown to 80% confluence in Hamm’s F12 medium with 10% fetal bovine serum and without hypoxanthine. Trypsinized cells are seeded in 6-well plates at 1 × 106 cells/well in 2 ml of medium without fetal bovine serum. After 24 h, medium is replaced with 1 ml of serum-free medium containing GSK-3 inhibitor or control (final DMSO concentration <0.1%) for 30 min at 37°C. Cells are lysed and centrifuged 15 min at 4°C/14000g. The activity ratio of GS is calculated as the GS activity in the absence of glucose-6-phosphate divided by the activity in the presence of 5 mmol/l glucose-6-phosphate, using the filter paper assay of Thomas et al.

Animal Research:

Diabetes,2003 Mar;52(3):588-95.

Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo.[Pubmed: 12606497]

Animal Models: Female db/db mice; Male ZDF rats
Dosages: 8-48 mg/kg
Administration: oral administration

Product Name	CHIR-99021 (CT99021)
Price:
CAS No.:	252917-06-9
Catalog No.:	CFN60026
Molecular Formula:	C₂₂H₁₈Cl₂N₈
Molecular Weight:	465.34 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library CDK Inhibitor Library Autophagy Inhibitor Library

Description:	CHIR-99021 (CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs. CHIR99021 functions as a Wnt/β-catenin activator and induces autophagy.
Targets:	GSK-3α/GSK-3β \| CDK \| Autophagy

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.149 mL	10.7448 mL	21.4897 mL	42.9793 mL	53.7242 mL
5 mM	0.4298 mL	2.149 mL	4.2979 mL	8.5959 mL	10.7448 mL
10 mM	0.2149 mL	1.0745 mL	2.149 mL	4.2979 mL	5.3724 mL
50 mM	0.043 mL	0.2149 mL	0.4298 mL	0.8596 mL	1.0745 mL
100 mM	0.0215 mL	0.1074 mL	0.2149 mL	0.4298 mL	0.5372 mL

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CFN97121	Benzoic acid	65-85-0	122.1	C₇H₆O₂
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