Calebassine | CAS:7257-29-6 | Manufacturer ChemFaces

Calebassine

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Description:

Calebassine is a competitive neuromuscular blocking agent, it is also a Mdm2/MdmX inhibitor.

In vitro:

Arch Int Pharmacodyn Ther. 1975 Jun;215(2):246-58.

Chemical structure and pharmacological (curarizing) properties of various indole alkaloids extracted from an African Strychnos.[Pubmed: 126050]

The chemical separation and identification of ten alkaloids extracted from the roots of Strychnos usambarensis are described.
METHODS AND RESULTS:
The elucidation of their structure by means of elementary analysis, I. R., U.V, and mass spectrometry allows their classification into bistertiary amines, hybrid and bisquaternary ammonium derivatives. This classification is reflected in the pharmacological properties. One of the tertiary amine alkaloids (usambarensine) presents atopine-like and spasmolytic activities while the bisquaternary ammonium compounds (dihydrotoxiferine, Calebassine, C-curarine and afrocurarine) are competitive neuromuscular blocking agents.

Calebassine Description

Source:	The seeds of Strychnos nux-vomica Linn.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Calebassine
Price:
CAS No.:	7257-29-6
Catalog No.:	CFN90130
Molecular Formula:	C₄₂H₅₂N₄O₂
Molecular Weight:	644.9 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The seeds of Strychnos nux-vomica Linn.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.5506 mL	7.7531 mL	15.5063 mL	31.0126 mL	38.7657 mL
5 mM	0.3101 mL	1.5506 mL	3.1013 mL	6.2025 mL	7.7531 mL
10 mM	0.1551 mL	0.7753 mL	1.5506 mL	3.1013 mL	3.8766 mL
50 mM	0.031 mL	0.1551 mL	0.3101 mL	0.6203 mL	0.7753 mL
100 mM	0.0155 mL	0.0775 mL	0.1551 mL	0.3101 mL	0.3877 mL

CFN90244	Brucine	357-57-3	394.46	C₂₃H₂₆N₂O₄
CFN90316	Brucine sulfate	4845-99-2	887.01	C₄₆H₅₄N₄O₁₂S
CFN98130	Strychnine	57-24-9	334.41	C₂₁H₂₂N₂O₂
CFN96442	Vomicine	125-15-5	380.4	C₂₂H₂₄N₂O₄
CFN90130	Calebassine	7257-29-6	644.9	C₄₂H₅₂N₄O₂
CFN99473	Conophylline	142741-24-0	794.9	C₄₄H₅₀N₄O₁₀