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Chasmanine
Chasmanine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Chasmanine
Price: $518 / 10mg
CAS No.: 5066-78-4
Catalog No.: CFN98587
Molecular Formula: C25H41NO6
Molecular Weight: 451.6 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The roots of Aconitum chrysotrichum W. T. Wang
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $336.7 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Chasmanine, hypaconitine, and deoxyaconitine are anti-inflammatory pharmacodynamic components in Heishunpian (HSP) with positive relations with HSP efficacy. Chasmanine has insecticidal activities against larvae of Bradysia odoriphaga Yan et Zhang.
Targets: Immunology & Inflammation related
In vitro:
J Agric Food Chem. 2011 Apr 27;59(8):3701-6.
Feeding deterrents from Aconitum episcopale roots against the red flour beetle, Tribolium castaneum.[Pubmed: 21417277]

METHODS AND RESULTS:
The screening for insecticidal principles from several Chinese medicinal herbs showed that the ethanol extract of Aconitum episcopale roots possessed significant feeding deterrence against the red flour beetle, Tribolium castaneum . From the ethanol extract, six feeding deterrents were isolated by bioassay-guided fractionation. The compounds were identified as Chasmanine, crassicauline A, karacoline, sachaconitine, talatisamine, and yunaconitine from their spectroscopic data. Chasmanine, talatisamine, karacoline, and sachaconitine exhibited feeding deterrent activity against T. castaneum adults, with EC(50) values of 297.0, 342.8, 395.3, and 427.8 ppm, respectively.
CONCLUSIONS:
Yunaconitine and crassicauline A also possessed feeding deterrent activity against T. castaneum adults, with EC(50) values of 653.4 and 1134.5 ppm, respectively.
Molecules. 2012 May 4;17(5):5187-94.
Diterpenoid alkaloids from the Chinese traditional herbal [Pubmed: 22628040]

METHODS AND RESULTS:
Ten diterpenoid alkaloids, including eight aconitine-type C₁₉-diterpenoid alkaloids and two hetisine-type C₂₀-diterpenoid alkaloids, were isolated from the secondary roots of Aconitum carmichaeli Debx., known as "Fuzi" in Chinese traditional herbal medicine. Their structures were established on the basis of their spectroscopic data and comparison with those of the literature. Among these alkaloids, Chasmanine, oxonitine and 15-acetylsongoramine were isolated for the first time from this medicinal plant.
CONCLUSIONS:
The cytotoxic activity of the alkaloids were tested against several cell lines by the MTT method in which aconitine, hypaconitine, mesaconitne and oxonitine were found to strongly inhibit the growth of the HePG2 cell line, which showed that the existence and quantity of the ester groups have a significant influence on the cytotoxicity of the diterpenoid alkaloids.
Rsc Advances, 2015, 5(28):22209-16.
A practical and novel “standard addition” strategy to screen pharmacodynamic components in traditional Chinese medicine using Heishunpian as an example[Reference: WebLink]

METHODS AND RESULTS:
Results showed that hypaconitine, deoxyaconitine and Chasmanine were anti-inflammatory PCs in HSP with positive relations with HSP efficacy.
CONCLUSIONS:
Thus, SA was used to systematically evaluate the effect of chemical ingredients in TCM. The proposed method presents simple operation, strong feasibility and reliability, and provides a new approach for screening PCs in TCM in a manner that highlights the complexity and multi-component effects of TCM.
Chasmanine Description
Source: The roots of Aconitum chrysotrichum W. T. Wang
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.2143 mL 11.0717 mL 22.1435 mL 44.287 mL 55.3587 mL
5 mM 0.4429 mL 2.2143 mL 4.4287 mL 8.8574 mL 11.0717 mL
10 mM 0.2214 mL 1.1072 mL 2.2143 mL 4.4287 mL 5.5359 mL
50 mM 0.0443 mL 0.2214 mL 0.4429 mL 0.8857 mL 1.1072 mL
100 mM 0.0221 mL 0.1107 mL 0.2214 mL 0.4429 mL 0.5536 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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