| In vitro: |
| Pharm Biol. 2013 Sep;51(9):1204-7. | | Cytotoxic and potential anticancer constituents from the stems of Schisandra pubescens.[Pubmed: 23883077] |
METHODS AND RESULTS:
Nine known compounds were obtained, including four lignans, epischisandrone (1), tigloylgomisin P (2), cagayanone (3) and (-)-gomisin L₂ (4), together with five triterpenoids, micranoic acid B (5), lancifodilactone H (6), Coccinic acid (7), schisanlactone B (8) and anwuweizonic acid (9).
CONCLUSIONS:
Compounds 2-6 and 8 showed moderate to marginal cytotoxicity, with GI₅₀ values of 11.83-35.65 μM. | | Chinese Journal of Modern Applied Pharmacy, 2002, 19(2):103-5. | | Antifertility Triterpenoid Acids from Kadsura angustifolia.[Reference: WebLink] | To isolate and characterize bioactive compounds from the stems of Kadsura angustifolia .
METHODS AND RESULTS:
The compounds were extracted with solvent,isolated by column chromatography and identified by the spectroscopic methods. eight compounds and a mixture of two triterpenoid acids were isolated and identified as epi anwuweizic acid (1),shikimic acid (2),(+) catechin (3),poriferast 5 en 3β,7α diol (4),β sitosterol (5),daucosterol (6),cerotic acid 1 monoglyceride (7) and behenic acid 1 monoglyceride (8),and mixiture of Coccinic acid (9) and anwuweizonic acid (10).
CONCLUSIONS:
Mixture of 9 and 10 showed significant inhibitory activity against human decidual cells and rat luteal cells in vitro . Compounds 2~4,7 and 8 were first reported in the family Schisandraceae,and compounds 1,5,6,9 and 10 were isolated from K.angustifolia for the first time. |
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