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Conopharyngine
Conopharyngine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Conopharyngine
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CAS No.: 76-98-2
Catalog No.: CFN96068
Molecular Formula: C23H30N2O4
Molecular Weight: 398.5 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Voacanga africana
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Standard reference
In vivo:
Neuropharmacology.1973 Mar;12(3):239-244.
Structure-activity relationships of intracerebrally injected tremorigenic indole alkaloids.[Reference: WebLink]

METHODS AND RESULTS:
The indole alkaloids harmane, harmine, ibogaine, iboxygaine and ibogaline caused tremor in mice when injected intracerebrally. Harmol, voacangine, voacristine and Conopharyngine were inactive in this respect. Chemical structure strongly influences tremorigenic potency which is increased by a methoxy group and reduced or abolished by a hydroxy or carbomethoxy group.
CONCLUSIONS:
The great importance of chemical structure for tremorigenic power of indole alkaloids points to specific receptors for these drugs in the brain.
Conopharyngine Description
Source: The herbs of Voacanga africana
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.5094 mL 12.5471 mL 25.0941 mL 50.1882 mL 62.7353 mL
5 mM 0.5019 mL 2.5094 mL 5.0188 mL 10.0376 mL 12.5471 mL
10 mM 0.2509 mL 1.2547 mL 2.5094 mL 5.0188 mL 6.2735 mL
50 mM 0.0502 mL 0.2509 mL 0.5019 mL 1.0038 mL 1.2547 mL
100 mM 0.0251 mL 0.1255 mL 0.2509 mL 0.5019 mL 0.6274 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Helvetica Chimica Acta.1975; 58(1):211–230.
Über Umwandlungen der Iboga-Alkaloide Voacangin und Conopharyngin 154. Mitteilung über Alkaloide.[Reference: WebLink]

METHODS AND RESULTS:
The reduction products voacanginol (3) and conopharynginol (4), obtained from the indole alkaloids voacangine (1) and Conopharyngine (2) respectively, gave, by the treatment of their tosylates 5 und 6 with triethylamine, two fragmentation products, voaenamine (7) (70–80%) and conoenamine (8) (25–45%) respectively (Scheme 1).
CONCLUSIONS:
The structures of 7 and 8 were derived from spectroscopic evidence and some chemical transformations.
CFN90318Catharanthine Tartrate2648-21-5486.40C21H24N2O2.C4H6O6
CFN93298Catharanthine Sulfate70674-90-7434.51C21H26N2O6S
CFN9843219,20-(E)-Vallesamine3368-87-4340.4 C20H24N2O3
CFN99377Vallesamine N-oxide126594-73-8356.4 C20H24N2O4
CFN97275Methyl demethoxycarbonylchanofruticosinate80151-89-9352.4 C21H24N2O3
CFN9745611,12-De(methylenedioxy)danuphylline888482-17-5426.5 C23H26N2O6
CFN99459Methyl chanofruticosinate14050-92-1410.5 C23H26N2O5
CFN96107Apparicine2122-36-3264.4C18H20N2
CFN97329Ibogaine83-74-9310.4 C20H26N2O
CFN96649Tabernanthine83-94-3310.44C20H26N2O
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