| Kinase Assay: |
| Mol Cancer Ther. 2008 Oct;7(10):3306-17. | | Coronarin D, a labdane diterpene, inhibits both constitutive and inducible nuclear factor-kappa B pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis.[Pubmed: 18852134] |
METHODS AND RESULTS:
We investigated the effect of Coronarin D on NF-kappaB activation pathway, NF-kappaB-regulated gene products, and NF-kappaB-regulated cellular responses. The Coronarin D inhibited NF-kappaB activation induced by different inflammatory stimuli and carcinogens.Coronarin D also inhibited the NF-kappaB-regulated gene products involved in cell survival (inhibitor of apoptosis protein 1, Bcl-2, survivin, and tumor necrosis factor receptor-associated factor-2), proliferation (c-myc, cyclin D1, and cyclooxygenase-2), invasion (matrix metalloproteinase-9), and angiogenesis (vascular endothelial growth factor).Coronarin D was found to be more potent than its analogue Coronarin D acid.
CONCLUSIONS:
Overall, our results show that Coronarin D inhibited NF-kappaB activation pathway, which leads to inhibition of inflammation, invasion, and osteoclastogenesis, as well as potentiation of apoptosis. |
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| Structure Identification: |
| Bioorg Med Chem Lett. 2011 Dec 15;21(24):7460-5. | | Chemical constituents of the rhizomes of Hedychium coronarium and their inhibitory effect on the pro-inflammatory cytokines production LPS-stimulated in bone marrow-derived dendritic cells.[Pubmed: 22071304] |
METHODS AND RESULTS:
The rhizomes of Hedychium coronarium have been used for the treatment of inflammation, skin diseases, headache, and sharp pain due to rheumatism in traditional medicine. From this plant, three new labdane-type diterpenes 1-3, named coronarins G-I as well as seven known 4-10, Coronarin D, Coronarin D methyl ether, hedyforrestin C, (E)-nerolidol, β-sitosterol, daucosterol, and stigmasterol were isolated. |
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