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Dehydroabietinol
Dehydroabietinol
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Dehydroabietinol
Price:
CAS No.: 3772-55-2
Catalog No.: CFN98609
Molecular Formula: C20H30O
Molecular Weight: 286.5 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The barks of Pinus yunnanensis.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: Dehydroabietinol inhibits growth of chloroquine-sensitive as well as chloroquine-resistant strains of Plasmodium falciparum cultivated in erythrocytes in vitro (IC 50 26-27 microM).
Targets: Antifection
In vitro:
Planta Med. 2002 Jun;68(6):547-9.
Possible artefacts in the in vitro determination of antimalarial activity of natural products that incorporate into lipid bilayer: apparent antiplasmodial activity of dehydroabietinol, a constituent of Hyptis suaveolens.[Pubmed: 12094303]

METHODS AND RESULTS:
Dehydroabietinol isolated from Hyptis suaveolens (L.) Poit. was found to inhibit growth of chloroquine-sensitive as well as chloroquine-resistant strains of Plasmodium falciparum cultivated in erythrocytes in vitro (IC 50 26-27 microM). However, erythrocytes exposed to Dehydroabietinol were transformed in a dose-dependent manner towards spherostomatocytic forms with concomitant formation of endovesicles, as disclosed by transmission electron microscopy. The erythrocyte shape alterations caused by Dehydroabietinol correlated well with its apparent IC 50 value.
CONCLUSIONS:
Thus, Dehydroabietinol incorporates into the erythrocyte membrane, and since invasion and survival of Plasmodium parasites is known to depend on the function of the erythrocyte membrane, the observed antiplasmodial effect of Dehydroabietinol is presumably an indirect effect on the host cell. Because of these findings, microscopic investigations should be generally used to support claims of antimalarial effects of apolar natural products.
Dehydroabietinol Description
Source: The barks of Pinus yunnanensis.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.4904 mL 17.452 mL 34.904 mL 69.808 mL 87.26 mL
5 mM 0.6981 mL 3.4904 mL 6.9808 mL 13.9616 mL 17.452 mL
10 mM 0.349 mL 1.7452 mL 3.4904 mL 6.9808 mL 8.726 mL
50 mM 0.0698 mL 0.349 mL 0.6981 mL 1.3962 mL 1.7452 mL
100 mM 0.0349 mL 0.1745 mL 0.349 mL 0.6981 mL 0.8726 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Forsythoside A

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CAS No: 79916-77-1
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Luteolin-6-C-glucoside

Catalog No: CFN98137
CAS No: 4261-42-1
Price: $128/20mg
Kurarinone

Catalog No: CFN92003
CAS No: 34981-26-5
Price: $118/20mg
Peonidin-3-O-arabinoside chloride

Catalog No: CFN92047
CAS No: 524943-91-7
Price: $318/5mg
3'-Demethylnobiletin

Catalog No: CFN93130
CAS No: 112448-39-2
Price: $188/10mg
Cannabigerol

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CAS No: 25654-31-3
Price: $338/10mg
4-O-Feruloylquinic acid

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Baicalin

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Loliolid

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Luteolin-4'-O-glucoside

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