Diosbulbin D | CAS:66756-57-8 | Manufacturer ChemFaces

Diosbulbin D

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Description:

Diosbulbin D shows direct toxic effect on hepatocytes, the mechanism could be associated with oxidative stress.

Targets:

ROS

In vitro:

Chinese Journal of Natural Medicines, 2011, 9(4):280-5.

Toxicity of a Diterpene Lactone Isolated from Dioscorea bulbifera on Hepatocytes[Reference: WebLink]

To test the toxic effects of a diterpene lactone, diosbulbin-D, isolated from Dioscorea bulbifera L. on hepatocytes.
METHODS AND RESULTS:
Using the MTT assay to test the effect of Diosbulbin D on hepatocytes.Selected intracellular enzymes release levels by diosbulbin-D were determined to further validate the toxic effect on hepatocytes.Furthermore,the level of intracellular glutathione and the induction of reactive oxygen species(ROS) by diosbulbin-D were measured by fluorometric and flow cytometry methods. Diosbulbin-D showed toxic effect on hepatocytes and a significant increase in intracellular release levels of LDH and the liver enzymes,alanine aminotransferase and aspartate aminotransferase confirmed diosbulbin-D's toxic effect.ROS increase was related to the decrease in level of GSH.Cell pretreated NAC almost completely blocked the ROS fluorescence and recovered the cell growth inhibition induced by diosbulbin-D.
CONCLUSIONS:
Diosbulbin-D shows direct toxic effect on hepatocytes.The mechanism could be associated with oxidative stress.

Diosbulbin D Description

Source:	The roots of Dioscorea bulbifera
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Diosbulbin D
Price:
CAS No.:	66756-57-8
Catalog No.:	CFN97140
Molecular Formula:	C₁₉H₂₀O₆
Molecular Weight:	344.4 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The roots of Dioscorea bulbifera
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Hepatotoxicity Compound Library Diterpenoids Compound Library ROS Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9036 mL	14.518 mL	29.036 mL	58.072 mL	72.59 mL
5 mM	0.5807 mL	2.9036 mL	5.8072 mL	11.6144 mL	14.518 mL
10 mM	0.2904 mL	1.4518 mL	2.9036 mL	5.8072 mL	7.259 mL
50 mM	0.0581 mL	0.2904 mL	0.5807 mL	1.1614 mL	1.4518 mL
100 mM	0.029 mL	0.1452 mL	0.2904 mL	0.5807 mL	0.7259 mL

CFN96274	Borapetoside E	151200-49-6	536.6	C₂₇H₃₆O₁₁
CFN96317	Borapetoside D	151200-48-5	698.7	C₃₃H₄₆O₁₆
CFN98015	Diosbulbin C	20086-07-1	362.4	C₁₉H₂₂O₇
CFN98014	Diosbulbin B	20086-06-0	344.4	C₁₉H₂₀O₆
CFN97837	Methyl-Dodovisate A	1246937-33-6	326.43	C₂₁H₂₆O₃
CFN99251	Isosalvipuberulin	115321-32-9	334.3	C₂₀H₁₄O₅
CFN99378	Tilifodiolide	126724-95-6	336.3	C₂₀H₁₆O₅
CFN97753	Dodonolide	349534-73-2	312.41	C₂₀H₂₄O₃
CFN97140	Diosbulbin D	66756-57-8	344.4	C₁₉H₂₀O₆
CFN90907	8-Epidiosbulbin E acetate	91095-48-6	388.40	C₂₁H₂₄O₇