Eupalitin | CAS:29536-41-2 | Manufacturer ChemFaces

Eupalitin

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $175.7 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Eupalitin has anti-cancer activity, it induces apoptosis in prostate carcinoma cells through ROS generation and increase of caspase-3 activity.

Targets:

Caspase | ROS | Apoptosis

In vitro:

Cell Biology International, 2016, 40(2):196-203.

Eupalitin induces apoptosis in prostate carcinoma cells through ROS generation and increase of caspase-3 activity.[Reference: WebLink]

Prostate cancer is the second most common malignancy in the human reproductive system. Eupalitin is one of the O-methylated flavonol-exhibited enhanced cancer chemopreventive agents. The current study highlights the structural determination of Eupalitin and aims to explore the antitumor activity of Eupalitin in human prostate cancer cell (PC3) and its underlying mechanism.
METHODS AND RESULTS:
Eupalitin structure was determined by using FTIR, (1)H NMR, and (13)C NMR. PC3 cells were treated with increasing concentrations of Eupalitin, followed by analysis of the cell viability with an MTT assay. The results demonstrated that Eupalitin markedly inhibited the proliferation of PC3 cells in a concentration-dependent manner. The results from fluorescent microscopic analysis of nuclear condensation and intracellular ROS generation determined that Eupalitin significantly induced ROS level lead to nuclear apoptosis. Cell cycle analysis revealed that Eupalitin-induced cell cycle progression as a percentage of cells in G0/G1 phase decreased whereas S phase increased. Caspase-3 immunofluorescence analysis confirms the efficacy of Eupalitin-inducing apoptotic pathway and cell death.
CONCLUSIONS:
Thus, our study is helpful in understanding the mechanism underlying these effects in prostate cancer and it may provide novel molecular targets for prostate cancer therapy.

Journal of Medicinal Plants Research,2013,7(20):1401-1405.

Eupalitin from Asparagus falcatus (Linn.) has anti-cancer activity and induces activation of caspases 3/7 in human colorectal tumor cells.[Reference: WebLink]

METHODS AND RESULTS:
3,5,4′-Trihydroxy-6,7-dimethoxy-flavone (Eupalitin) has been isolated from the leaves ofAsparagus falcatus (Linn.). Anti-proliferation and apoptosis studies were conducted on Eupalitin. Results showed that Eupalitin exhibited significant cytotoxicity against human colorectal tumor cells. It is found that Eupalitin induces the activation of caspases 3/7, a hallmark of apoptosis.
CONCLUSIONS:
The study suggests that the anti-proliferative property of Eupalitin towards the human colorectal tumor cells may be probably due to its capability to induce apoptosis in cells.

Eupalitin Description

Source:	The herbs of Artemisia asiatica
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Eupalitin
Price:	$318 / 10mg
CAS No.:	29536-41-2
Catalog No.:	CFN70334
Molecular Formula:	C₁₇H₁₄O₇
Molecular Weight:	330.3 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The herbs of Artemisia asiatica
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Flavonoids Compound Library ROS Inhibitor Library Caspase Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.0276 mL	15.1378 mL	30.2755 mL	60.551 mL	75.6888 mL
5 mM	0.6055 mL	3.0276 mL	6.0551 mL	12.1102 mL	15.1378 mL
10 mM	0.3028 mL	1.5138 mL	3.0276 mL	6.0551 mL	7.5689 mL
50 mM	0.0606 mL	0.3028 mL	0.6055 mL	1.211 mL	1.5138 mL
100 mM	0.0303 mL	0.1514 mL	0.3028 mL	0.6055 mL	0.7569 mL

CFN99796	Cholic acid	81-25-4	408.57	C₂₂H₄₀O₅
CFN92211	3-O-cis-p-Coumaroyltormentic acid	121072-40-0	634.9	C₃₉H₅₄O₇
CFN97892	3'-Geranyl-3-prenyl-2',4',5,7-tetrahydroxyflavone	1334309-44-2	490.6	C₃₀H₃₄O₆
CFN92874	Yuexiandajisu D	866556-15-2	350.4	C₂₀H₃₀O₅