GL3 | CAS:60037-39-0 | Manufacturer ChemFaces

GL3

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Size /Price /Stock	10 mM * 1 mL in DMSO / $115.1 / In-stock
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Description:

GL3 encodes a bHLH protein that regulates trichome development in arabidopsis through interaction with GL1 and TTG1.

In vitro:

Plant Physiol. 2007 Nov;145(3):736-46.

Participation of the Arabidopsis bHLH factor GL3 in trichome initiation regulatory events.[Pubmed: 17885086 ]

The development of trichomes (leaf hairs) from pluripotent epidermal cells in Arabidopsis (Arabidopsis thaliana) provides a powerful system to investigate the regulatory motifs involved in plant cell differentiation.
METHODS AND RESULTS:
We show here that trichome initiation is triggered within 4 h of the induction of the GLABRA3 (GL3) basic helix-loop-helix transcription factor. Within this developmental window, GL3 binds to the promoters of at least three genes previously implicated in the development and patterning of trichomes (GL2, CAPRICE, and ENHANCER OF TRIPTYCHON AND CAPRICE1) and activates their transcription. The in vivo binding of GL3 to the promoters of these genes requires the presence of the R2R3-MYB factor GL1, supporting a model in which a GL3-GL1 complex is part of the trichome initiation enhanceosome. In contrast, GL3 is recruited to its own promoter in a GL1-independent manner, and this results in decreased GL3 expression, suggesting the presence of a GL3 negative autoregulatory loop. In support of genetic analyses indicating that ENHANCER OF GL3 (EGL3) is partially redundant with GL3, we show that EGL3 shares some direct targets with GL3. However, our results suggest that GL3 and EGL3 work independently of each other.
CONCLUSIONS:
Taken together, our results provide a regulatory framework to understand early events of epidermal cell differentiation.

GL3 Description

Source:	The seeds of Ligustrum lucidum
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Genetics. 2000 Nov;156(3):1349-62.

GL3 encodes a bHLH protein that regulates trichome development in arabidopsis through interaction with GL1 and TTG1.[Pubmed: 11063707 ]

Arabidopsis trichome development and differentiation is a well-studied model for plant cell-fate determination and morphogenesis.
METHODS AND RESULTS:
Mutations in TRANSPARENT TESTA GLABRA1 (TTG1) result in several pleiotropic defects including an almost complete lack of trichomes. The complex phenotype caused by ttg1 mutations is suppressed by ectopic expression of the maize anthocyanin regulator R. Here it is demonstrated that the Arabidopsis trichome development locus GLABRA3 (GL3) encodes an R homolog. GL3 and GLABRA1 (GL1) interact when overexpressed together in plants. Yeast two-hybrid assays indicate that GL3 participates in physical interactions with GL1, TTG1, and itself, but that GL1 and TTG1 do not interact.
CONCLUSIONS:
These data suggest a reiterated combinatorial model for the differential regulation of such diverse developmental pathways as trichome cell-fate determination, root hair spacing, and anthocyanin secondary metabolism.

Product Name	GL3
Price:	$288 / 20mg
CAS No.:	60037-39-0
Catalog No.:	CFN80115
Molecular Formula:	C₄₈H₆₄O₂₇
Molecular Weight:	1073.02 g/mol
Purity:	>=98%
Type of Compound:	Iridoids
Physical Desc.:	Powder
Source:	The seeds of Ligustrum lucidum
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Iridoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	0.9319 mL	4.6597 mL	9.3195 mL	18.639 mL	23.2987 mL
5 mM	0.1864 mL	0.9319 mL	1.8639 mL	3.7278 mL	4.6597 mL
10 mM	0.0932 mL	0.466 mL	0.9319 mL	1.8639 mL	2.3299 mL
50 mM	0.0186 mL	0.0932 mL	0.1864 mL	0.3728 mL	0.466 mL
100 mM	0.0093 mL	0.0466 mL	0.0932 mL	0.1864 mL	0.233 mL

CFN99838	Oleoside	178600-68-5	390.3	C₁₆H₂₂O₁₁
CFN98996	Secoxyloganin	58822-47-2	404.4	C₁₇H₂₄O₁₁
CFN91892	Methyloleoside	60539-23-3	404.37	C₁₇H₂₄O₁₁
CFN97229	Secoxyloganin methyl ester	74713-15-8	418.4	C₁₈H₂₆O₁₁
CFN97683	Secologanin dimethyl acetal	77988-07-9	434.44	C₁₉H₃₀O₁₁
CFN98159	Cornuside	131189-57-6	542.49	C₂₄H₃₀O₁₄
CFN90972	Depressine	176182-06-2	688.63	C₃₀H₄₀O₁₈
CFN95365	7-O-(4-beta-D-glucopyranosyloxy-3-methoxybenzoyl)secologanolic acid	469899-55-6	688.6	C₃₀H₄₀O₁₈
CFN95374	New compound 13	N/A	718.7	C₃₁H₄₂O₁₉
CFN97045	Grandifloroside	61186-24-1	538.5	C₂₅H₃₀O₁₃