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Hopeyhopin
Hopeyhopin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Hopeyhopin
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CAS No.: 63975-56-4
Catalog No.: CFN89250
Molecular Formula: C15H14O5
Molecular Weight: 274.27 g/mol
Purity: >=98%
Type of Compound: Coumarins
Physical Desc.: Powder
Source: The herbs of Micromelum falcatum.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Hopeyhopin is a natural product from Micromelum falcatum.
In vitro:
Phytochemistry. 2013 Apr;88:79-84.
Benzene, coumarin and quinolinone derivatives from roots of Citrus hystrix.[Pubmed: 23352239 ]

METHODS AND RESULTS:
Two coumarins, hystrixarin (1) and (+)-Hopeyhopin (2); a benzenoid derivative, hystroxene-I (3) and a quinolinone alkaloid, hystrolinone (4), along with 33 known compounds were isolated from the crude acetone extract of the roots of Citrus hystrix.
CONCLUSIONS:
Their structures were determined by analysis of 1D and 2D NMR spectroscopic data. The antioxidant, anti-HIV and antibacterial activities of the isolated compounds were also evaluated.
Hopeyhopin Description
Source: The herbs of Micromelum falcatum.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.646 mL 18.2302 mL 36.4604 mL 72.9208 mL 91.1511 mL
5 mM 0.7292 mL 3.646 mL 7.2921 mL 14.5842 mL 18.2302 mL
10 mM 0.3646 mL 1.823 mL 3.646 mL 7.2921 mL 9.1151 mL
50 mM 0.0729 mL 0.3646 mL 0.7292 mL 1.4584 mL 1.823 mL
100 mM 0.0365 mL 0.1823 mL 0.3646 mL 0.7292 mL 0.9115 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Zhong Yao Cai. 2013 May;36(5):744-6.
Study on the chemical constituents from ethyl acetate extract of Micromelum falcatum.[Pubmed: 24218965]
To study the chemical constituents from ethyl acetate extract of Micromelum falcatum.
METHODS AND RESULTS:
The constituents were separated and purified by silica gel, Sephadex LH-20 and HPLC. Their structures were elucidated by spectral analysis (NMR, MS). Ten compounds were isolated and identified as micropubescin (1), phebalosin (2), scopoletin (3), citrubuntin (4), thamnosmonin (5), Hopeyhopin (6), arnottinin (7), casegravol (8), 2-methoxy-5-hydroxy cinnamate (9), threo-syringoylglycerol (10).
CONCLUSIONS:
Compounds 1 - 10 are obtained from this plant for the first time.
CFN92733Toddaculine4335-12-0274.3C16H18O4
CFN90247Toddalolactone483-90-9308.33C16H20O6
CFN95372Toddalolactone 3'-O-methyl ether (6-(2-Hydroxy-3-methoxy-3-methylbutyl)-5,7-dimethoxycoumarin)143614-35-1322.4C17H22O6
CFN92513(-)-Toddanol77715-99-2290.3C16H18O5
CFN92514Toddanone77636-08-9290.3C16H18O5
CFN927325-Methoxysuberenone85011-58-1274.3C15H14O5
CFN98985Suberosin581-31-7244.3 C15H16O3
CFN89248Dehydrogeijerin16850-91-2258.27C15H14O4
CFN89250Hopeyhopin63975-56-4274.27C15H14O5
CFN96622Thamnosmonin60094-90-8276.28C15H16O5
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