Incensole | CAS:22419-74-5 | Manufacturer ChemFaces

Incensole

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Description:

Incensole has a protective or stimulating effect on β-cells of the rat pancreas, it also can increase the insulin secretion, which evidenced by a significant increase both in body weight and in liver glycogen.

In vivo:

Planta Med 2015; 81 - PB3

Hypoglycemic and hypolipidemic activities of incensole from Olibanum on streptozotocin diabetic rats[Reference: WebLink]

Incensole is a macrocyclic diterpene with a wide spectrum of bioactivities. It was isolated from the oleogum resin of Boswellia carterii Birdwood.
METHODS AND RESULTS:
This study discusses for the first time the potential hypoglycemic and hypolipidemic effects of Incensole on diabetic rats. Biochemical and histochemical studies completed and confirmed our findings. Diabetes was induced in rats by streptozotocin (STZ, 40 mg/kg), which is a selective β-cells destructor. Incensole was administered daily to diabetic rats at 5 and 10 mg/kg for thirty days. Several parameters were measured including body weight, blood glucose level, lipid profile and plasma enzymes (SGPT, SGOT and ALP). All studies were performed in comparison with the standard drug "Glibenclamide". Results showed that Incensole is effective in lowering the blood-glucose level in the experimental rat model (201.7 ± 9.236) compared to the disease control group (588.8 ± 11.43).
CONCLUSIONS:
Biochemical and histopathological studies proved that Incensole has a protective or stimulating effect on β-cells of the rat pancreas. It also increased the insulin secretion; evidenced by a significant increase both in body weight and in liver glycogen.

Incensole Description

Source:	The resin of Boswellia carterii Birdw.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Incensole
Price:	$318 / 20mg
CAS No.:	22419-74-5
Catalog No.:	CFN93208
Molecular Formula:	C₂₀H₃₄O₂
Molecular Weight:	306.5 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The resin of Boswellia carterii Birdw.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antihyperglycemic Compound Library Anti-hyperlipidemic Compound Library Diterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.2626 mL	16.3132 mL	32.6264 mL	65.2529 mL	81.5661 mL
5 mM	0.6525 mL	3.2626 mL	6.5253 mL	13.0506 mL	16.3132 mL
10 mM	0.3263 mL	1.6313 mL	3.2626 mL	6.5253 mL	8.1566 mL
50 mM	0.0653 mL	0.3263 mL	0.6525 mL	1.3051 mL	1.6313 mL
100 mM	0.0326 mL	0.1631 mL	0.3263 mL	0.6525 mL	0.8157 mL

CFN91050	Nephthenol	53915-41-6	290.49	C₂₀H₃₄O
CFN93208	Incensole	22419-74-5	306.5	C₂₀H₃₄O₂
CFN93207	Incensole acetate	34701-53-6	348.5	C₂₂H₃₆O₃
CFN90426	Mevastatin	73573-88-3	390.51	C₂₃H₃₄O₅
CFN99961	Lovastatin	75330-75-5	404.54	C₂₄H₃₆O₅
CFN90427	Simvastatin	79902-63-9	418.56	C₂₅H₃₈O₅
CFN90153	Sauchinone	177931-17-8	356.36	C₂₀H₂₀O₆
CFN92879	Fischeria A	221456-63-9	288.4	C₁₉H₂₈O₂
CFN97452	Kongensin A	885315-96-8	374.5	C₂₂H₃₀O₅
CFN99078	3,10-Dihydroxy-5,11-dielmenthadiene-4,9-dione	106623-23-8	332.4	C₂₀H₂₈O₄