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Ingenol 20-palmitate
Ingenol 20-palmitate
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Ingenol 20-palmitate
Price:
CAS No.: 39071-33-5
Catalog No.: CFN89401
Molecular Formula: C36H58O6
Molecular Weight: 586.84 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Oil
Source: The roots of Euphorbia sieboldiana.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Ingenol 20-palmitate is a natural product from Euphorbia sieboldiana.
In vitro:
Experientia. 1976 Sep 15;32(9):1196-7.
Tumor promoting constituent of Euphorbia serrata L. latex.[Pubmed: 971764]

METHODS AND RESULTS:
Euphorbia serrata latex has initially ingenol-3-palmitate, which by action of silica gel is converted to Ingenol 20-palmitate.
CONCLUSIONS:
The former is responsible for the irritant and cocarcinogenic activity of the latex on mouse ear and on mice back skin.
Ingenol 20-palmitate Description
Source: The roots of Euphorbia sieboldiana.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.704 mL 8.5202 mL 17.0404 mL 34.0808 mL 42.601 mL
5 mM 0.3408 mL 1.704 mL 3.4081 mL 6.8162 mL 8.5202 mL
10 mM 0.1704 mL 0.852 mL 1.704 mL 3.4081 mL 4.2601 mL
50 mM 0.0341 mL 0.1704 mL 0.3408 mL 0.6816 mL 0.852 mL
100 mM 0.017 mL 0.0852 mL 0.1704 mL 0.3408 mL 0.426 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Planta Med. 1991 Dec;57(6):569-71.
New Diterpenoids from Euphorbia sieboldiana.[Pubmed: 17226204 ]

METHODS AND RESULTS:
From the acetone extract of roots of EUPHORBIA SIEBOLDIANA, three known diterpenes, ENT-atisane-3beta,16alpha,17-triol ( 1), ingenol ( 4), and helioscopinolide A ( 5) as well as two new diterpenes, 3beta- O-acetyl- ENT-atisane-16alpha,17-diol ( 2), and Ingenol 20-palmitate ( 3) were isolated.
CONCLUSIONS:
Their structures were elucidated by spectroscopic methods and chemical transformations.
CFN928673-O-(2'E,4'Z-Decadienoyl)ingenol84680-59-1498.7C30H42O6
CFN928643-O-(2'E ,4'Z-decadienoyl)-20-O-acetylingenol158850-76-1540.7C32H44O7
CFN928683-O-(2'E,4'E-Decadienoyl)ingenol466663-11-6498.7C30H42O6
CFN928653-O-(2'E ,4'E-decadienoyl)-20-O-acetylingenol466663-12-7540.7C32H44O7
CFN89409Ingenol 3-palmitate52557-26-3586.84C36H58O6
CFN89401Ingenol 20-palmitate39071-33-5586.84C36H58O6
CFN9324413-Oxyingenol dodecanoat54706-70-6546.74C32H50O7
CFN9036712-O-tetradecanoylphorbol-13-acetate16561-29-8616.83C36H56O8
CFN96233Euphohelioscopin A87064-61-7498.7C30H42O6
CFN95325Lathyranoic acid A850560-44-0494.6C29H34O7
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