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Lettowienolide
Lettowienolide
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Lettowienolide
Price:
CAS No.: 1189105-39-2
Catalog No.: CFN91934
Molecular Formula: C18H22O3
Molecular Weight: 286.37 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Source: The herbs of Lettowianthus stellatus
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Lettowienolide exhibits mild in vitro activity against the Plasmodium falciparum malaria parasite ( IC(50) approximately 20 microg/mL).
Targets: Antifection
In vitro:
Nat Prod Res. 2010 May;24(8):710-7.
Geranylbenzoquinonoids from Lettowianthus stellatus fruits.[Pubmed: 20432152]

METHODS AND RESULTS:
The geranylbenzoquinonoids 7-(3,7-dimethylocta-2,6-dienyl)-5-hydroxy-3H-benzofuran-2-one (Lettowienolide), dimethyl 2,3-bis-[5-(3,7-dimethylocta-2,6-dienyl)-3,6-dioxocyclohexa-1,4-dienyl]-succinate (lettowiquinone), 2-(3,7-dimethylocta-2,6-dienyl)-6-[7-(3,7-dimethylocta-2,6-dienyl)-5-hydroxybenzofuran-2-yl]-[1,4]benzoquinone (lettowifuraquinone), methyl [3-(3,7-dimethylocta-2,6-dienyl)-6-methyl-5-(3-methylbut-2-enyl)-1,4-dioxo-1,5, 8,8a-tetrahydro-4H-nathphalen-4a-yl)]-acetate (lettowinone) and methyl [6-hydroxy-2-methyl-2-(4-methylpent-3-enyl)-2H-chromen-8-yl]-acetate (lettowipyraquinol) were isolated from fruits of Lettowianthus stellatus Diels, together with juvenile hormone III and 7-octadecen-9-ynoic acid.
CONCLUSIONS:
Lettowienolide and lettowiquinone exhibited mild in vitro activity against the Plasmodium falciparum malaria parasite (each IC(50) approximately 20 microg mL(-1)). Structural determination was achieved based on extensive analysis of spectroscopic data.
Lettowienolide Description
Source: The herbs of Lettowianthus stellatus
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.492 mL 17.4599 mL 34.9199 mL 69.8397 mL 87.2996 mL
5 mM 0.6984 mL 3.492 mL 6.984 mL 13.9679 mL 17.4599 mL
10 mM 0.3492 mL 1.746 mL 3.492 mL 6.984 mL 8.73 mL
50 mM 0.0698 mL 0.3492 mL 0.6984 mL 1.3968 mL 1.746 mL
100 mM 0.0349 mL 0.1746 mL 0.3492 mL 0.6984 mL 0.873 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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