Methyl 3-(2,4-dihydroxyphenyl)propionate | CAS:17422-90-1

Methyl 3-(2,4-dihydroxyphenyl)propionate

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Product Name	Methyl 3-(2,4-dihydroxyphenyl)propionate
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CAS No.:	17422-90-1
Catalog No.:	CFN99823
Molecular Formula:	C₁₀H₁₂O₄
Molecular Weight:	196.2 g/mol
Purity:	>=98%
Type of Compound:	Phenylpropanoids
Physical Desc.:	Oil
Source:	The herbs of Juniperus formosana
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Methyl 3-(2,4-dihydroxyphenyl)propionate has inhibitory effects on tyrosinase, antioxidant ability, and lightening effect of ultraviolet B (UVB)-induced hyperpigmentation.

In vitro:

Lipids. 2001 Dec;36(12):1321-6.

Novel vitamin E derivative with 4-substituted resorcinol moiety has both antioxidant and tyrosinase inhibitory properties.[Pubmed: 11834083]

METHODS AND RESULTS:
A novel vitamin E derivative, (6"-hydroxy-2",5",7",8"-tetramethylchroman-2"-yl)Methyl 3-(2,4-dihydroxyphenyl)propionate (TM4R), which has a chromanoxyl ring and 4-substituted resorcinol moieties, was synthesized; and its inhibitory effects on tyrosinase, antioxidant ability, and lightening effect of ultraviolet B (UVB)-induced hyperpigmentation were estimated.Methyl 3-(2,4-dihydroxyphenyl)propionate showed potent inhibitory activity on tyrosinase, which is the rate-limiting enzyme in melanogenesis. The scavenging activities of Methyl 3-(2,4-dihydroxyphenyl)propionate on 1,1-diphenyl-2-picrylhydrazyl and hydroxyl radicals were found to be nearly the same as those of alpha-tocopherol. Furthermore, an efficient lightening effect was observed following topical application of Methyl 3-(2,4-dihydroxyphenyl)propionate to UVB-stimulated hyperpigmented dorsal skin of brownish guinea pigs.
CONCLUSIONS:
These results suggest that Methyl 3-(2,4-dihydroxyphenyl)propionate may be a candidate for an efficient whitening agent, possibly by inhibiting tyrosinase activity and biological reactions caused by reactive oxygen species.

Methyl 3-(2,4-dihydroxyphenyl)propionate Description

Source:	The herbs of Juniperus formosana
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Phenylpropanoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	5.0968 mL	25.4842 mL	50.9684 mL	101.9368 mL	127.421 mL
5 mM	1.0194 mL	5.0968 mL	10.1937 mL	20.3874 mL	25.4842 mL
10 mM	0.5097 mL	2.5484 mL	5.0968 mL	10.1937 mL	12.7421 mL
50 mM	0.1019 mL	0.5097 mL	1.0194 mL	2.0387 mL	2.5484 mL
100 mM	0.051 mL	0.2548 mL	0.5097 mL	1.0194 mL	1.2742 mL

CFN99539	Danshensu	22681-72-7	198.17	C₉H₁₀O₅
CFN99163	Sodium Danshensu	67920-52-9	220.2	C₉H₉O₅Na
CFN99800	Levodopa	59-92-7	197.20	C₉H₁₁NO₄
CFN92549	Trans-caffeic acid	501-16-6	180.2	C₉H₈O₄
CFN95561	Methyl caffeate acid	3843-74-1	194.18	C₁₀H₁₀O₄
CFN97136	Ethyl caffeate	66648-50-8	208.2	C₁₁H₁₂O₄
CFN90554	Caffeic acid phenethyl ester	104594-70-9	284.31	C₁₇H₁₆O₄
CFN96779	Nepetoidin B	55486-06-1	314.29	C₁₇H₁₄O₆
CFN89444	Cinnamyl caffeate	115610-32-7	296.31	C₁₈H₁₆O₄
CFN89462	Cinnamyl coumarate	115610-30-5	280.31	C₁₈H₁₆O₃