Methyleugenol | CAS:93-15-2 | Manufacturer ChemFaces

Methyleugenol

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Description:

Methyleugenol (ME) is a natural constituent of the essential oils of a number of plants widely used in foodstuffs as flavouring agents, in view of the carcinogenic potential of ME, the need to check its presence in food products with effective analytical methods. ME has elaxant and antispasmodic actions on guinea-pig isolated ileum, it also has antinociceptive, anti-inflammatory, and insecticidal properties.ME can inhibit the production of nitric oxide and decreased the protein expression of inducible nitric oxide synthase, it down-regulates the production of pro-inflammatory cytokines in the ischemic brain as well as in immunostimulated mixed glial cells.

Targets:

NOS | NMDAR | Caspase | COX | GABA Receptor

In vivo:

Free Radical. Res., 2010, 44(8):925-35.

Methyleugenol reduces cerebral ischemic injury by suppression of oxidative injury and inflammation.[Pubmed: 20815773 ]

METHODS AND RESULTS:
The present study tested the cytoprotective effect of Methyleugenol in an in vivo ischemia model (i.e. middle cerebral artery occlusion (MCAO) for 1.5 h and subsequent reperfusion for 24 h) and further investigated its mechanism of action in in vitro cerebral ischemic models. When applied shortly after reperfusion, Methyleugenol largely reduced cerebral ischemic injury. Methyleugenol decreased the caspase-3 activation and death of cultured cerebral cortical neurons caused by oxygen-glucose deprivation (OGD) for 1 h and subsequent re-oxygenation for 24 h. Methyleugenol markedly reduced superoxide generation in the ischemic brain and decreased the intracellular oxidative stress caused by OGD/re-oxygenation. It was found that Methyleugenol elevated the activities of superoxide dismutase and catalase. Further, Methyleugenol inhibited the production of nitric oxide and decreased the protein expression of inducible nitric oxide synthase. Methyleugenol down-regulated the production of pro-inflammatory cytokines in the ischemic brain as well as in immunostimulated mixed glial cells.
CONCLUSIONS:
The results indicate that Methyleugenol could be useful for the treatment of ischemia/inflammation-related diseases.

Methyleugenol Description

Source:	The herbs of Syringa Linn.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Animal Research:

Eur. J. Pharmacol., 2006, 553(3):99-103.

Antinociceptive effect of methyleugenol on formalin-induced hyperalgesia in mice.[Pubmed: 17049512 ]

METHODS AND RESULTS:
The effects of Methyleugenol, an essential oil isolated from Asiasari radix, on antinociception were examined using the formalin test in mice. Oral administration of 10 mg/kg Methyleugenol significantly decreased the duration of licking and biting behavior in the second phase without affecting that of the first phase, as did diclofenac, a non-steroidal anti-inflammatory drug. Methyleugenol also inhibited pain-related behaviors induced by intrathecal injection of N-methyl-d-aspartic acid (NMDA), while diclofenac did not affect these behaviors. These effects of Methyleugenol were suppressed by bicuculline, a gamma-aminobutyric acid(A) (GABA(A)) antagonist. Muscimol, a GABA(A) agonist, displays the same action as Methyleugenol with respect to the formalin test and NMDA-induced behaviors. Methyleugenol did not affect cyclooxygenase-1 and -2 activities.
CONCLUSIONS:
These results suggest that the antinociceptive effect of Methyleugenol on the second phase of formalin-induced pain may be due to the inhibition of NMDA receptor-mediated hyperalgesia via GABA(A) receptors.

Product Name	Methyleugenol
Price:	$30 / 20mg
CAS No.:	93-15-2
Catalog No.:	CFN96177
Molecular Formula:	C₁₁H₁₄O₂
Molecular Weight:	178.2 g/mol
Purity:	>=98%
Type of Compound:	Phenylpropanoids
Physical Desc.:	Oil
Source:	The herbs of Syringa Linn.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	5.6117 mL	28.0584 mL	56.1167 mL	112.2334 mL	140.2918 mL
5 mM	1.1223 mL	5.6117 mL	11.2233 mL	22.4467 mL	28.0584 mL
10 mM	0.5612 mL	2.8058 mL	5.6117 mL	11.2233 mL	14.0292 mL
50 mM	0.1122 mL	0.5612 mL	1.1223 mL	2.2447 mL	2.8058 mL
100 mM	0.0561 mL	0.2806 mL	0.5612 mL	1.1223 mL	1.4029 mL

CFN97095	cis-Methylisoeugenol	6380-24-1	178.2	C₁₁H₁₄O₂
CFN96259	trans-Methylisoeugenol	6379-72-2	178.2	C₁₁H₁₄O₂
CFN96231	3,4-Dimethoxycinnamyl alcohol	40918-90-9	194.2	C₁₁H₁₄O₃
CFN92632	Syringylpropane	6766-82-1	196.2	C₁₁H₁₆O₃
CFN96354	Acantrifoside E	645414-25-1	356.4	C₁₇H₂₄O₈
CFN90573	Pimentol	141913-95-3	494.5	C₂₃H₂₆O₁₂
CFN97886	Isoelemicin	5273-85-8	208.3	C₁₂H₁₆O₃
CFN90685	Elemicin	487-11-6	208.3	C₁₂H₁₆O₃
CFN95820	5-Allyl-1-methoxy-2,3-dihydroxybenzene	4055-72-5	180.2	C₁₀H₁₂O₃
CFN90589	Myristicin	607-91-0	192.21	C₁₁H₁₂O₃