N-(3-Methoxybenzyl)oleamide | CAS:883715-21-7

N-(3-Methoxybenzyl)oleamide

ChemFaces products have been cited in many studies from excellent and top scientific journals

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $79.4 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Our products had been exported to the following research institutions and universities, And still growing.

St. Jude Children Research Hosp... (USA)
Johannes Gutenberg University M... (Germany)
Ain Shams University (Egypt)
Gyeongsang National University (Korea)

University of Madras (India)
Almansora University (Egypt)
Universidade de Franca (Brazil)
University of Ioannina (Greece)

Research Unit Molecular Epigene... (Germany)
Universiti Malaysia Pahang (Malaysia)
Melbourne University (Australia)
More...

Package

Featured Products

More...

Sakakin

Catalog No: CFN98059
CAS No: 21082-33-7
Price: $40/20mg

Taurocholic acid

Catalog No: CFN96646
CAS No: 81-24-3
Price: $ / mg

Limocitrin

Catalog No: CFN92385
CAS No: 489-33-8
Price: $ / mg

Ganoderic acid B

Catalog No: CFN92052
CAS No: 81907-61-1
Price: $288/20mg

Saponin

Catalog No: CFN70204
CAS No: 8047-15-2
Price: $30/20mg

Terpineol

Catalog No: CFN92688
CAS No: 98-55-5
Price: $30/20mg

Higenamine

Catalog No: CFN93353
CAS No: 5843-65-2
Price: $80/20mg

Costunolide

Catalog No: CFN98928
CAS No: 553-21-9
Price: $40/20mg

Alizarin

Catalog No: CFN92568
CAS No: 72-48-0
Price: $30/20mg

Nuciferine

Catalog No: CFN99733
CAS No: 475-83-2
Price: $40/20mg

Description:

Macamides (N-(3-methoxybenzyl)oleamide (MAC 18:1), N-(3-methoxybenzyl)linoleamide (MAC 18:2) and N-(3-methoxybenzyl)linolenamide (MAC 18:3) )achieve their neuroprotective effects by binding to CB1 receptors to protect against Mn-induced toxicity in U-87 MG glioblastoma cells. Additionally these macamides, in a manner similar to the analogous endocannabinoid AEA, interact with other targets such as PPARγ to regulate metabolism and energy homeostasis, cell differentiation and inflammation.

Targets:

PPARγ

In vitro:

Toxicol Appl Pharmacol, 2018, 340:67-76.

Neuroprotective activity of macamides on manganese-induced mitochondrial disruption in U-87 MG glioblastoma cells.[Reference: WebLink]

Macamides are a distinct class of secondary metabolites, benzylamides of long chain fatty acids, which were isolated from the Peruvian plant Lepidium meyenii (Maca). As structural analogues of the endocannabinoid anandamide (AEA), they have demonstrated neuroprotective effects in vitro and in vivo. The purpose of this study was to demonstrate the neuroprotective activity of the macamides: N-(3-Methoxybenzyl)oleamide (MAC 18:1), N-(3-methoxybenzyl)linoleamide (MAC 18:2) and N-(3-methoxybenzyl)linolenamide (MAC 18:3) in a neurotoxic environment caused by exposure of U-87 MG glioblastoma cells to manganese chloride (MnCl2). The neuroprotective effects of these macamides were reversed by the CB1 antagonist AM251.
METHODS AND RESULTS:
The mechanism by which manganese (Mn) induces cell damage was investigated by studying its effects on mitochondria. Reactive oxygen species (ROS) increase intracellular calcium and enhance the opening of mitochondrial permeability transition pores (MPTP), which leads to decreased mitochondrial membrane potential (MMP), to disruption of mitochondria and to neuron death in neurodegenerative disorders. In this study, MnCl2 at 50 μM was responsible for mitochondrial disruption, which was attenuated by all three of the macamides tested. Human peroxisome proliferator-activated receptor gamma (PPARγ) has been proposed to be a cannabinoid target, and PPARγ has also been demonstrated to mediate some of the longer-term vascular effects of the plant cannabinoid, ∆ 9-tetrahydrocannabinol. PPARγ activation was observed in response to exposures of cells to MAC 18:2 and MAC 18:3.
CONCLUSIONS:
These findings suggest that macamides achieve their neuroprotective effects by binding to CB1 receptors to protect against Mn-induced toxicity in U-87 MG glioblastoma cells. Additionally these macamides, in a manner similar to the analogous endocannabinoid AEA, interact with other targets such as PPARγ to regulate metabolism and energy homeostasis, cell differentiation and inflammation.

N-(3-Methoxybenzyl)oleamide Description

Source:	The herbs of Lepidium meyenii Walp
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	N-(3-Methoxybenzyl)oleamide
Price:	$218 / 20mg
CAS No.:	883715-21-7
Catalog No.:	CFN90847
Molecular Formula:	C₂₆H₄₃NO₂
Molecular Weight:	401.6 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Oil
Source:	The herbs of Lepidium meyenii Walp
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.49 mL	12.4502 mL	24.9004 mL	49.8008 mL	62.251 mL
5 mM	0.498 mL	2.49 mL	4.9801 mL	9.9602 mL	12.4502 mL
10 mM	0.249 mL	1.245 mL	2.49 mL	4.9801 mL	6.2251 mL
50 mM	0.0498 mL	0.249 mL	0.498 mL	0.996 mL	1.245 mL
100 mM	0.0249 mL	0.1245 mL	0.249 mL	0.498 mL	0.6225 mL

CFN91684	Palvanil	69693-13-6	391.6	C₂₄H₄₁NO₃
CFN90241	Nordihydrocapsaicin	28789-35-7	293.40	C₁₇H₂₇NO₃
CFN99917	Capsaicin	404-86-4	305.42	C₁₈H₂₇NO₃
CFN99918	Dihydrocapsaicin	19408-84-5	307.43	C₁₈H₂₉NO₃
CFN90964	Homodihydrocapsaicin I	20279-06-5	321.45	C₁₉H₃₁NO₃
CFN91410	Dihydrohomocapsaicin II	71239-21-9	321.5	C₁₉H₃₁NO₃
CFN99529	Leonurine hydrochloride	24735-18-0	347.8	C₁₄H₂₁O₅N₃.HCl
CFN97210	Odorine	72755-20-5	300.4	C₁₈H₂₄N₂O₂
CFN97211	Odorinol	72755-22-7	316.4	C₁₈H₂₄N₂O₃
CFN90843	Macamide B	74058-71-2	345.6	C₂₃H₃₉NO