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Neosenkirkine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Neosenkirkine
Price:
CAS No.: 57194-70-4
Catalog No.: CFN00426
Molecular Formula: C19H27NO6
Molecular Weight: 365.42 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Cryst.
Source: The herbs of Senecio scandens
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • VIB Department of Plant Systems... (Belgium)
  • Rio de Janeiro State University (Brazil)
  • Sanford Burnham Prebys Medical ... (USA)
  • Technical University of Denmark (Denmark)
  • University of Madras (India)
  • University of Medicine and Phar... (Romania)
  • Sri Ramachandra University (India)
  • National Chung Hsing University (Taiwan)
  • Max Rubner-Institut (MRI) (Germany)
  • University of Otago (New Zealand)
  • Universiti Sains Malaysia (Malaysia)
  • More...
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: Reference standards.
Neosenkirkine Description
Source: The herbs of Senecio scandens
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.7366 mL 13.6829 mL 27.3658 mL 54.7315 mL 68.4144 mL
5 mM 0.5473 mL 2.7366 mL 5.4732 mL 10.9463 mL 13.6829 mL
10 mM 0.2737 mL 1.3683 mL 2.7366 mL 5.4732 mL 6.8414 mL
50 mM 0.0547 mL 0.2737 mL 0.5473 mL 1.0946 mL 1.3683 mL
100 mM 0.0274 mL 0.1368 mL 0.2737 mL 0.5473 mL 0.6841 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Journal of Food Composition and Analysis,2015,42; 1–7.
Hepatotoxic pyrrolizidine alkaloids in Emilia sonchifolia from Taiwan[Reference: WebLink]
Emilia sonchifolia (L.) DC. (Lilac tasselflower, Zi Bei Cao) is used in Asian countries for food or medicinal purposes. We have investigated the hepatotoxic pyrrolizidine alkaloids (PAs) contained in E. sonchifolia. The objective was to determine profile and quantity of the PAs in E. sonchifolia samples that were collected from several towns in Taiwan.
METHODS AND RESULTS:
Pyrrolizidine alkaloids were isolated and purified from the aqueous acid extracts by use of strong cation exchange-solid phase extraction (SCX-SPE). Alkaloid extracts were analyzed using gas–chromatography mass spectrometry (GC–MS). Eleven PAs of two types were identified in E. sonchifolia (by type): (1) retronecine bases, senecionine, seneciphylline and integerrimine; (2) otonecine bases, senkirkine, otosenine, Neosenkirkine, petasitenine, acetylsenkirkine, desacetyldoronine, acetylpetasitenine, and doronine. Quantification of the individual PAs was determined by six-point linear regression curves in the range of 25–400 μg/mL of senkirkine and senecionine. The PAs were found in all plant organs of E. sonchifolia. Senkirkine was the major PA identified with concentrations up to 53.8 μg/g of dry herb. The average total PA concentration varied from a low of 33.3 μg/g to a high of 93.9 μg/g dry herb.
CONCLUSIONS:
This study will provide important information to public consumers regarding the health risk of PA-containing E. sonchifolia.
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