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Polygalasaponin XXXI
Polygalasaponin XXXI
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Polygalasaponin XXXI
Price: $268 / 5mg
CAS No.: 79103-90-5
Catalog No.: CFN90728
Molecular Formula: C75H112O36
Molecular Weight: 1589.67 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The herbs of Polygala japonica Houtt.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $553.2 / In-stock
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Onjisaponin F(Polygalasaponin XXXI) acts non-competitively against cyclic AMP phosphodiesterase, like papaverine; it also exhibits a prolongation effect on hexobarbital sleeping time in mice. Intranasal vaccination with onjisaponin F(Polygalasaponin XXXI) can inhibit proliferation of mouse adapted influenza virus A/PR/8/34 in bronchoalveolar lavages of infected mice.
Targets: cAMP
In vivo:
Acta Horticulturae, 2005 , 679 (679) :121-129.
Intranasally and orally effective adjuvants from Chinese and Japanese medicinal herbs for nasal influenza vaccine[Reference: WebLink]
Active substances from hot water extracts from 267 different Chinese and Japanese medicinal herbs were screened for mucosal adjuvant activity with influenza HA vaccine in mice. The extract from the root of Polygala tenuifolia was found to contain potent mucosal adjuvant activity.
METHODS AND RESULTS:
The active substances were purified and identified as onjisaponins A, E, F and G. Two inoculations of mice with onjisaponin F ((Polygalasaponin XXXI,1 μg) and influenza HA vaccine (1 μg) at 3 weeks intervals, significantly increased serum HI antibody and nasal anti-influenza virus IgA and IgG antibody titers after only 1 week over mice given HA vaccine alone after the secondary vaccination. Intranasal vaccination with onjisaponin F(Polygalasaponin XXXI) inhibited proliferation of mouse adapted influenza virus A/PR/8/34 in bronchoalveolar lavages of infected mice. Onjisaponins also showed adjuvant effect for intranasal vaccination of diphtheria-pertussis-tetanus (DPT) vaccine.
CONCLUSIONS:
Traditional Japanese herbal (Kampo) formulation, Sho-seiryu-to (Xiao-Qing-Long-Tang in Chinese) showed oral adjuvant activity for nasally administered influenza vaccine.
Polygalasaponin XXXI Description
Source: The herbs of Polygala japonica Houtt.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 0.6291 mL 3.1453 mL 6.2906 mL 12.5812 mL 15.7265 mL
5 mM 0.1258 mL 0.6291 mL 1.2581 mL 2.5162 mL 3.1453 mL
10 mM 0.0629 mL 0.3145 mL 0.6291 mL 1.2581 mL 1.5727 mL
50 mM 0.0126 mL 0.0629 mL 0.1258 mL 0.2516 mL 0.3145 mL
100 mM 0.0063 mL 0.0315 mL 0.0629 mL 0.1258 mL 0.1573 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Chemical & Pharmaceutical Bulletin, 1982 , 30 (6) :2020-2024.
Inhibitors of cyclic adenosine monophosphate phosphodiesterase in Polygala tenuifolia[Reference: WebLink]
Cyclic adenosine monophosphate (AMP) phosphodiesterase inhibitors contained in Polygala tenuifolia WILLD. were identified as saponins and oleic acid. The concentrations of onjisaponins E, F and G required to give 50% inhibition (IC 50) were of the sameor der as that of papaverine.
METHODS AND RESULTS:
A kinetic study revealed that onjisaponin F(Polygalasaponin XXXI) acts non-competitively against cyclic AMP phosphodiesterase, like papaverine. Onjisaponin F(Polygalasaponin XXXI) exhibited a prolongation effect on hexobarbital sleeping time in mice.
CFN95347Secotubeimoside I106235-32-91337.5C60H100O30
CFN90915Tubeimoside II115810-12-31335.5C63H98O30
CFN90916Tubeimoside III115810-13-41365.5C64H100O31
CFN90672Macranthoidin A140360-29-81237.4C59H96O27
CFN95624Patrinia saponin H3197013-75-51383.6C65H106O31
CFN95359Dipsacus saponin X146100-01-81677.8C76H124O40
CFN91053Huzhangoside B94795-70-71337.51C64H104O29
CFN95711Huzhangoside C96315-52-51337.5C64H104O29
CFN90384Huzhangoside D96315-53-61353.51C64H104O30
CFN99148Macranthoidin B136849-88-21399.52C65H106O32
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