Polygalasaponin XXXI | CAS:79103-90-5 | Manufacturer ChemFaces

Polygalasaponin XXXI

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $553.2 / In-stock
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Description:

Onjisaponin F(Polygalasaponin XXXI) acts non-competitively against cyclic AMP phosphodiesterase, like papaverine; it also exhibits a prolongation effect on hexobarbital sleeping time in mice. Intranasal vaccination with onjisaponin F(Polygalasaponin XXXI) can inhibit proliferation of mouse adapted influenza virus A/PR/8/34 in bronchoalveolar lavages of infected mice.

Targets:

cAMP

In vivo:

Acta Horticulturae, 2005 , 679 (679) :121-129.

Intranasally and orally effective adjuvants from Chinese and Japanese medicinal herbs for nasal influenza vaccine[Reference: WebLink]

Active substances from hot water extracts from 267 different Chinese and Japanese medicinal herbs were screened for mucosal adjuvant activity with influenza HA vaccine in mice. The extract from the root of Polygala tenuifolia was found to contain potent mucosal adjuvant activity.
METHODS AND RESULTS:
The active substances were purified and identified as onjisaponins A, E, F and G. Two inoculations of mice with onjisaponin F ((Polygalasaponin XXXI,1 μg) and influenza HA vaccine (1 μg) at 3 weeks intervals, significantly increased serum HI antibody and nasal anti-influenza virus IgA and IgG antibody titers after only 1 week over mice given HA vaccine alone after the secondary vaccination. Intranasal vaccination with onjisaponin F(Polygalasaponin XXXI) inhibited proliferation of mouse adapted influenza virus A/PR/8/34 in bronchoalveolar lavages of infected mice. Onjisaponins also showed adjuvant effect for intranasal vaccination of diphtheria-pertussis-tetanus (DPT) vaccine.
CONCLUSIONS:
Traditional Japanese herbal (Kampo) formulation, Sho-seiryu-to (Xiao-Qing-Long-Tang in Chinese) showed oral adjuvant activity for nasally administered influenza vaccine.

Polygalasaponin XXXI Description

Source:	The herbs of Polygala japonica Houtt.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Polygalasaponin XXXI
Price:	$268 / 5mg
CAS No.:	79103-90-5
Catalog No.:	CFN90728
Molecular Formula:	C₇₅H₁₁₂O₃₆
Molecular Weight:	1589.67 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The herbs of Polygala japonica Houtt.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Antiviral Compound Library Triterpenoids Compound Library cAMP Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	0.6291 mL	3.1453 mL	6.2906 mL	12.5812 mL	15.7265 mL
5 mM	0.1258 mL	0.6291 mL	1.2581 mL	2.5162 mL	3.1453 mL
10 mM	0.0629 mL	0.3145 mL	0.6291 mL	1.2581 mL	1.5727 mL
50 mM	0.0126 mL	0.0629 mL	0.1258 mL	0.2516 mL	0.3145 mL
100 mM	0.0063 mL	0.0315 mL	0.0629 mL	0.1258 mL	0.1573 mL

CFN80187	Pulsatilla saponin H	68027-14-5	1382.67	C₆₅H₁₀₆O₃₁
CFN99990	Tubeimoside I	102040-03-9	1319.46	C₆₃H₉₈O₂₉
CFN95347	Secotubeimoside I	106235-32-9	1337.5	C₆₀H₁₀₀O₃₀
CFN90915	Tubeimoside II	115810-12-3	1335.5	C₆₃H₉₈O₃₀
CFN90916	Tubeimoside III	115810-13-4	1365.5	C₆₄H₁₀₀O₃₁
CFN90672	Macranthoidin A	140360-29-8	1237.4	C₅₉H₉₆O₂₇
CFN95624	Patrinia saponin H3	197013-75-5	1383.6	C₆₅H₁₀₆O₃₁
CFN95359	Dipsacus saponin X	146100-01-8	1677.8	C₇₆H₁₂₄O₄₀
CFN91053	Huzhangoside B	94795-70-7	1337.51	C₆₄H₁₀₄O₂₉
CFN95711	Huzhangoside C	96315-52-5	1337.5	C₆₄H₁₀₄O₂₉