Rediocide C | CAS:677277-98-4 | Manufacturer ChemFaces

Rediocide C

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Description:

Rediocide C exhibits antimycobacterial activity, with the MIC value of 3.84 uM; it also exhibits potent activity against D. pteronyssinus with respective LC50 values of 5.59 microg/cm2.

Targets:

Antifection

In vitro:

Chem Pharm Bull (Tokyo). 2005 Feb;53(2):241-3.

Acaricidal daphnane diterpenoids from Trigonostemon reidioides (KURZ) CRAIB roots.[Pubmed: 15684528]

METHODS AND RESULTS:
A new daphnane diterpenoid, rediocide F (1), was isolated together with three known compounds, rediocides A (2), C (3) and E (4), from the hexane extract of Trigonostemon reidioides roots by bioassay-guided fractionation for acaricidal activity on Dermatophagoides pteronyssinus, Thai common house dust mite. The structure of rediocide F (1) was established as the demethyl analog of Rediocide C (3) on the basis of spectral analysis.
CONCLUSIONS:
Compounds 1-4 exhibited potent activity against D. pteronyssinus with respective LC50 values of 2.53, 0.78, 5.59 and 0.92 microg/cm2.

Rediocide C Description

Source:	The herbs of Trigonostemon reidioides (Kurz) Craib.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Tetrahedron , 2017,73( 12):1594–1601.

Terpenoids with potent antimycobacterial activity against Mycobacterium tuberculosis from Trigonostemon reidioides roots[Reference: WebLink]

Phytochemical investigation of Trigonostemon reidioides roots led to the isolation of fourteen compounds. These included six new diterpenoids, trigonoreidons A−F (1−6), together with eight known diterpenoids 7−14.
METHODS AND RESULTS:
The structures of the new compounds were elucidated by spectroscopic techniques and the absolute configuration at the asymmetric carbon was determined by the modified Mosher's method. The structure of trigonoreidon B (2) was confirmed by X-ray crystallographic analysis. The known compounds were identified by comparison of the spectroscopic and physical data with those of reported values. The isolated compounds were evaluated for antimycobacterial activity against Mycobacterium tuberculosis.
CONCLUSIONS:
Among the compounds that exhibited antimycobacterial activity, the diterpenoids Rediocide C (12) and rediocide G (14) were the most active compounds, with the MIC value of 3.84 μM.

Product Name	Rediocide C
Price:
CAS No.:	677277-98-4
Catalog No.:	CFN97156
Molecular Formula:	C₄₆H₅₄O₁₃
Molecular Weight:	814.9 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The herbs of Trigonostemon reidioides (Kurz) Craib.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antibacterial Compound Library Acaricidal Compound Library Diterpenoids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.2271 mL	6.1357 mL	12.2714 mL	24.5429 mL	30.6786 mL
5 mM	0.2454 mL	1.2271 mL	2.4543 mL	4.9086 mL	6.1357 mL
10 mM	0.1227 mL	0.6136 mL	1.2271 mL	2.4543 mL	3.0679 mL
50 mM	0.0245 mL	0.1227 mL	0.2454 mL	0.4909 mL	0.6136 mL
100 mM	0.0123 mL	0.0614 mL	0.1227 mL	0.2454 mL	0.3068 mL

CFN98341	Rediocide A	280565-85-7	794.9	C₄₄H₅₈O₁₃
CFN97156	Rediocide C	677277-98-4	814.9	C₄₆H₅₄O₁₃