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Timosaponin AI
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Timosaponin AI
Price:
CAS No.: 68422-00-4
Catalog No.: CFN90917
Molecular Formula: C33H54O8
Molecular Weight: 578.78 g/mol
Purity: >=98%
Type of Compound: Steroids
Physical Desc.: Powder
Source: The rhizomes of Anemarrhena asphodeloides Bunge.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Timosaponin AI can inhibit dipeptidyl peptidase-4 (DPP-4) activity in a dose-dependent manner, the DPP-4 inhibitor has been clinically used for the treatment of type 2 diabetes mellitus.
In vitro:
Zhongguo Zhong Yao Za Zhi. 2016 Apr;41(7):1241-1245.
Screening and identification of DPP-4 inhibitors from Xiaokean formula by a fluorescent probe.[Pubmed: 28879738]
Fluorescent bio-probes have attracted increasing attentions in studies for screening bioactive compounds from traditional Chinese medicines.
METHODS AND RESULTS:
In this study, a new-type fluorescent probe with the function of aggregation-induced emission (AIE) was used to screen dipeptidyl peptidase-4 (DPP-4) inhibitor from Xiaokean formula, which has been clinically used for the treatment of type 2 diabetes mellitus. Potential DPP-4 inhibitors were screened by the fluorescent probe, with diprotin A as the positive control; totally 43 components were isolated from Xiaokean formula by systematic separation. The results showed that 13 components can exert inhibitory effects on DPP-4 activity; 16 compounds were further identified by liquid chromatography-mass spectrometry (LC-MS) from those active components. The inhibitory effects of 14 compounds were further verified, while five of them showed significant inhibition against DPP-4. Salvianolicacid C, ginsenoside Rg₅ and Timosaponin AI inhibited DPP-4 activity at the concentration of 5-50 μmol•L⁻1 in a dose-dependent manner.
CONCLUSIONS:
Thus, our study provided a successful example for screening bioactive compounds from traditional Chinese medicines by using a novelfluorescent probe.
Process Biochemistry, 2015, 50(12):2182-2187.
Preparation of some metabolites of Timosaponin BII by biotransformation in vitro.[Reference: WebLink]
Timosaponin BII (TBII) is an active constituent of some Chinese medicinal herbs, and is abundant in Anemarrhena asphodeloides Bunge.
METHODS AND RESULTS:
To better understand the pharmaceutical mechanisms of TBII, we prepared its deglycosylated derivatives through biotransformation with fungi Colletotrichum gloeosporioides, Acremonium alternatum and Aspergillus niger. In the presence of 10. g/L glucose, transformation with C. gloeosporioides yielded 4 products: Timosaponin AIII (P3) and Timosaponin AI (P5) and their beta isoforms (P2 and P4 respectively). However, P4 and P5 could not be detected when 0-5. g/L glucose was applied; P2 and P3 disappeared at 20. g/L glucose. P4 is a newly discovered compound.
CONCLUSIONS:
We firstly report that fungi in whole cell model can hydrolyze C3-. O-glucopyranosyl residues of steroidal saponins after removing the C26 sugar. Therefore, the transformation efficiency depends on glucose. Transformation of TBII, and maybe other steroidal saponins, with C. gloeosporioides is an ideal method to prepare the metabolites in vitro.
Timosaponin AI Description
Source: The rhizomes of Anemarrhena asphodeloides Bunge.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.7278 mL 8.6389 mL 17.2777 mL 34.5554 mL 43.1943 mL
5 mM 0.3456 mL 1.7278 mL 3.4555 mL 6.9111 mL 8.6389 mL
10 mM 0.1728 mL 0.8639 mL 1.7278 mL 3.4555 mL 4.3194 mL
50 mM 0.0346 mL 0.1728 mL 0.3456 mL 0.6911 mL 0.8639 mL
100 mM 0.0173 mL 0.0864 mL 0.1728 mL 0.3456 mL 0.4319 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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