Science | Nature | Cell | View More
Natural Products
Tokinolide B
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Tokinolide B
Price: $368 / 10mg
CAS No.: 112966-16-2
Catalog No.: CFN90612
Molecular Formula: C24H28O4
Molecular Weight: 380.48 g/mol
Purity: >=98%
Type of Compound: Miscellaneous
Physical Desc.: Powder
Source: The roots of Angelica sinensis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $203.3 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Max Rubner-Institut (MRI) (Germany)
  • Wroclaw Medical University (Poland)
  • Uniwersytet Jagielloński w Kra... (Poland)
  • University of Stirling (United Kingdom)
  • Heinrich-Heine-University Düss... (Germany)
  • University of Hull (United Kingdom)
  • VIT University (India)
  • Universita' Degli Studi Di Cagl... (Italy)
  • University of Maryland (USA)
  • Aarhus University (Denmark)
  • Leibniz Institute of Plant Bioc... (Germany)
  • More...
Package
Featured Products
5-Hydroxy-1,7-bis(4-hydroxyphenyl)...

Catalog No: CFN96291
CAS No: 1269839-24-8
Price: $318/10mg
Scutellarin

Catalog No: CFN99112
CAS No: 27740-01-8
Price: $30/20mg
Isoescin IA

Catalog No: CFN90932
CAS No: 219944-39-5
Price: $238/20mg
Loganic acid

Catalog No: CFN98212
CAS No: 22255-40-9
Price: $50/20mg
Delphinidin chloride

Catalog No: CFN92033
CAS No: 528-53-0
Price: $380/10mg
Pinoresinol 4-O-beta-D-glucopyrano...

Catalog No: CFN97180
CAS No: 69251-96-3
Price: $100/20mg
Taxifolin

Catalog No: CFN98734
CAS No: 480-18-2
Price: $30/20mg
Silymarin

Catalog No: CFN99542
CAS No: 22888-70-6
Price: $30/20mg
Alloimperatorin

Catalog No: CFN93037
CAS No: 642-05-7
Price: $298/10mg
Oxypeucedanin hydrate

Catalog No: CFN90557
CAS No: 2643-85-8
Price: $80/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Tokinolide B may have sedative and spasmolytic properties.
In vitro:
Nat Prod Res. 2011 Aug;25(13):1234-42.
Phthalides and other constituents from Ligusticum porteri; sedative and spasmolytic activities of some natural products and derivatives.[Pubmed: 21797735 ]

METHODS AND RESULTS:
The chemical constituents of the organic extracts from the rhizomes of Ligusticum porteri were isolated, characterised and identified as Z-ligustilide, Z-butylidenephthalide, diligustilide, Tokinolide B, riligustilide, senkyunolides F and I, ferulic acid, among other known compounds. The preparation of 4,5-dehydroTokinolide B from Tokinolide B is reported, and its structure confirmed by X-ray analysis. The sedative and spasmolytic activities of some of these natural products and derivatives were evaluated by applying them to in vivo and in vitro models.
CONCLUSIONS:
Several of these dimeric phthalides displayed sedative and spasmolytic properties that may correlate with some popular uses of L. porteri.
Tokinolide B Description
Source: The roots of Angelica sinensis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Quercetin 7-O-(6''-O-malonyl)-beta...

Catalog No: CFN95208
CAS No: 98767-37-4
Price: $388/10mg
Licoarylcoumarin

Catalog No: CFN95072
CAS No: 125709-31-1
Price: $413/5mg
Lyciumamide B

Catalog No: CFN95286
CAS No: 1647111-41-8
Price: $318/5mg
New compound 16

Catalog No: CFN95465
CAS No: N/A
Price: $413/5mg
Cannabisin P

Catalog No: CFN95456
CAS No: 2756983-19-2
Price: $318/5mg
Orientalide

Catalog No: CFN95136
CAS No: 72704-05-3
Price: $368/5mg
1-Methyl-2,8-dihydroxy-3-carboxy-9...

Catalog No: CFN95101
CAS No: 1401414-53-6
Price: $338/5mg
4-O-Caffeoyl-3-O-syringoylquinic a...

Catalog No: CFN95430
CAS No: 1207645-17-7
Price: $413/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6283 mL 13.1413 mL 26.2826 mL 52.5652 mL 65.7065 mL
5 mM 0.5257 mL 2.6283 mL 5.2565 mL 10.513 mL 13.1413 mL
10 mM 0.2628 mL 1.3141 mL 2.6283 mL 5.2565 mL 6.5706 mL
50 mM 0.0526 mL 0.2628 mL 0.5257 mL 1.0513 mL 1.3141 mL
100 mM 0.0263 mL 0.1314 mL 0.2628 mL 0.5257 mL 0.6571 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Zhongguo Zhong Yao Za Zhi. 2008 Oct;33(19):2196-201.
Study on biligustilides from Angelica sinensis.[Pubmed: 19166005]
To study the chemical constituents of Angelica sinensis.
METHODS AND RESULTS:
The constituents were separated by chromatographic methods, and their structures were identified on the basis of spectroscopic analysis. Eight compounds were isolated and identified as levistolide A (1), senkyunolide O (2), (3Z, 3Z')-6.8', 7.3'-diligustilide (3), Tokinolide B (4), isoTokinolide B (5), (3'Z)-(3R, 8S, 3a'R, 6'S)-3, 3a': 8, 6'-biligustilide (6), E, E'-3. 3', 8. 8'-diligustilide (7) and E, E'-3. 3', 8. 8'-isodiligustilide (8), which are all diligustilides.
CONCLUSIONS:
Compound 7 was obtained from the plant for the first time; compounds 6 and 8 are new compounds.
5-Hydroxy-1,7-bis(4-hydroxyphenyl)...

Catalog No: CFN96291
CAS No: 1269839-24-8
Price: $318/10mg
Scutellarin

Catalog No: CFN99112
CAS No: 27740-01-8
Price: $30/20mg
Isoescin IA

Catalog No: CFN90932
CAS No: 219944-39-5
Price: $238/20mg
Loganic acid

Catalog No: CFN98212
CAS No: 22255-40-9
Price: $50/20mg
Delphinidin chloride

Catalog No: CFN92033
CAS No: 528-53-0
Price: $380/10mg
Pinoresinol 4-O-beta-D-glucopyrano...

Catalog No: CFN97180
CAS No: 69251-96-3
Price: $100/20mg
Taxifolin

Catalog No: CFN98734
CAS No: 480-18-2
Price: $30/20mg
Silymarin

Catalog No: CFN99542
CAS No: 22888-70-6
Price: $30/20mg
Alloimperatorin

Catalog No: CFN93037
CAS No: 642-05-7
Price: $298/10mg
Oxypeucedanin hydrate

Catalog No: CFN90557
CAS No: 2643-85-8
Price: $80/20mg
Tags: buy Tokinolide B | Tokinolide B supplier | purchase Tokinolide B | Tokinolide B cost | Tokinolide B manufacturer | order Tokinolide B | Tokinolide B distributor