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Tripterifordin
Tripterifordin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Tripterifordin
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CAS No.: 139122-81-9
Catalog No.: CFN99442
Molecular Formula: C20H30O3
Molecular Weight: 318.5 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The roots of Tripterygium wilfordii
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Tripterifordin shows anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 1 microgram/ml.
Targets: HIV | Immunology & Inflammation related
In vitro:
J Nat Prod. 1992 Jan;55(1):88-92.
Anti-AIDS agents, 4. Tripterifordin, a novel anti-HIV principle from Tripterygium wilfordii: isolation and structural elucidation.[Pubmed: 1602302]
A new kaurane-type diterpene lactone, Tripterifordin [1], has been isolated from the roots of Tripterygium wilfordii.
METHODS AND RESULTS:
The structure of 1 was elucidated by spectroscopic methods, including the concerted application of a number of 2D nmr techniques that involved the 1H-1H COSY, heteronucleus-detected variants of the heteronuclear chemical shift correlation (HETCOR), phase-sensitive NOESY, and long-range HETCOR.
CONCLUSIONS:
Compound 1 shows anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 1 microgram/ml.
Tripterifordin Description
Source: The roots of Tripterygium wilfordii
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1397 mL 15.6986 mL 31.3972 mL 62.7943 mL 78.4929 mL
5 mM 0.6279 mL 3.1397 mL 6.2794 mL 12.5589 mL 15.6986 mL
10 mM 0.314 mL 1.5699 mL 3.1397 mL 6.2794 mL 7.8493 mL
50 mM 0.0628 mL 0.314 mL 0.6279 mL 1.2559 mL 1.5699 mL
100 mM 0.0314 mL 0.157 mL 0.314 mL 0.6279 mL 0.7849 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J Nat Prod. 1999 Nov;62(11):1522-5.
Immunosuppressive diterpenoids from Tripterygium wilfordii.[Pubmed: 10579865]

METHODS AND RESULTS:
A clinically used extract of Tripterygium wilfordii afforded three new diterpenoids-3beta,19-dihydroxyabieta-8,11,13-triene (triptobenzene L) (1); 12,19-dihydroxy-3-oxoabieta-8,11,13-triene (triptobenzene M) (2); and 19-hydroxy-3,7-dioxo-abieta-8,11, 13-triene (triptobenzene N) (3)-along with 14 known diterpenoids. The structures of 1-3 were established on the basis of spectroscopic studies. Of the known compounds, the stereochemistry at C-4 of triptonediol (4) was reassigned.
CONCLUSIONS:
Tripterifordin (8) and 13-epi-manoyl oxide-18-oic acid (9) showed significant inhibitory effects on cytokine production.
CFN99632ent-3-Oxokauran-17-oic acid151561-88-5318.5 C20H30O3
CFN99249Pseudolaric acid D115028-67-6318.5 C20H30O3
CFN96213Verbenacine717901-03-6318.5C20H30O3
CFN97263ent-11,16-Epoxy-15-hydroxykauran-19-oic acid77658-46-9334.5 C20H30O4
CFN90544Isosteviol27975-19-5318.45C20H30O3
CFN97262ent-9-Hydroxy-15-oxo-19-kauranoic acid77658-45-8334.5 C20H30O4
CFN97974Pterisolic acid E1401419-89-3350.5C20H30O5
CFN97972Pterisolic acid D1401419-88-2350.5C20H30O5
CFN99442Tripterifordin139122-81-9318.5 C20H30O3
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