Triptoquinone A | CAS:142950-86-5 | Manufacturer ChemFaces

Triptoquinone A

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Description:

Triptoquinone A may be a useful candidate for the development of a drug as a potent inhibitor of iNOS gene over-expression. Triptoquinone A has anti-inflammatory activity, it prevents ndotoxin-or interleukin-1 beta-promoted induction of nitric oxide synthase in vascular smooth muscle, thus inhibiting development of L-arginine-induced vasorelaxation.

Targets:

NO | NOS | IL Receptor

In vitro:

Biochem Biophys Res Commun. 1996 Jul 16;224(2):579-85.

Suppression of inducible nitric oxide synthase mRNA expression by tryptoquinone A.[Pubmed: 8702429 ]

Triptoquinone A (TQA), which is an anti-inflammatory constituent in plants, was studied for its suppressive effect on nitric oxide production by LPS.
METHODS AND RESULTS:
TQA significantly suppressed smooth muscle relaxation and increase in cyclic GMP levels by nitric oxide (NO) in an L-arginine-induced relaxation experiment. The mechanistic studies showed that TQA did not directly inhibit NO radicals and inducible nitric oxide synthase (iNOS) enzyme but suppressed IL-1 beta and iNOS mRNA expression by LPS. The suppression level of iNOS gene expression by TQA was comparable to that by dexamethasone.
CONCLUSIONS:
TQA may be a useful candidate for the development of a drug as a potent inhibitor of iNOS gene over-expression.

In vivo:

Life Sci. 1996;59(3):PL49-54.

Inhibition by triptoquinone-A of LPS- and IL-1 beta-primed induction of NO synthase in rat thoracic aorta.[Pubmed: 8699928]

METHODS AND RESULTS:
We investigated the effect of Triptoquinone A (TQA), an active principal of Triptergium wilfordii, on the induction of nitric oxide synthase (NOS) promoted by endotoxin (LPS) and interleukin-1 beta (IL-1 beta). Prophylactic application of TQA selectively prevented LPS-primed initiation of L-arginine (Arg)-induced relaxation, and cGMP formation of rat thoracic aorta, and LPS-stimulated nitrite production by cultured aortic smooth muscle cells, which appear to be mediated by NOS expressed by LPS in vascular smooth muscle. TQA also prevented IL-1 beta-triggered initiation of Arg-induced relaxation and nitrite accumulation.
CONCLUSIONS:
These results suggest that TQA prevents LPS-or IL-1 beta-promoted induction of NOS in vascular smooth muscle, thus inhibiting development of Arg-induced vasorelaxation.

Triptoquinone A Description

Source:	The roots of Tripterygium wilfordii Hook.f.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Triptoquinone A
Price:
CAS No.:	142950-86-5
Catalog No.:	CFN96475
Molecular Formula:	C₂₀H₂₄O₄
Molecular Weight:	328.40 g/mol
Purity:	>=98%
Type of Compound:	Quinones
Physical Desc.:	Orange powder
Source:	The roots of Tripterygium wilfordii Hook.f.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Inhibitors Compound Library Vasocontraction Compound Library Quinones Compound Library NOS Inhibitor Library NO Inhibitor Library IL Receptor Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.0451 mL	15.2253 mL	30.4507 mL	60.9013 mL	76.1267 mL
5 mM	0.609 mL	3.0451 mL	6.0901 mL	12.1803 mL	15.2253 mL
10 mM	0.3045 mL	1.5225 mL	3.0451 mL	6.0901 mL	7.6127 mL
50 mM	0.0609 mL	0.3045 mL	0.609 mL	1.218 mL	1.5225 mL
100 mM	0.0305 mL	0.1523 mL	0.3045 mL	0.609 mL	0.7613 mL

CFN91653	Tripchlorolide	132368-08-2	396.86	C₂₀H₂₅ClO₆
CFN90404	Triptophenolide	74285-86-2	312.4	C₂₀H₂₄O₃
CFN99690	Triptoquinonide	163513-81-3	326.4	C₂₀H₂₂O₄
CFN91917	Triptobenzene K	198129-88-3	342.39	C₂₀H₂₂O₅
CFN91913	Neotriptophenolide	81827-74-9	342.43	C₂₁H₂₆O₄
CFN91912	Triptohairic acid	220209-71-2	328.45	C₂₁H₂₈O₃
CFN99474	Triptoquinone B	142937-50-6	330.4	C₂₀H₂₆O₄
CFN96475	Triptoquinone A	142950-86-5	328.40	C₂₀H₂₄O₄
CFN96479	Triptinin B	189389-05-7	314.42	C₂₀H₂₆O₃
CFN96478	Triptobenzene H	146900-55-2	344.45	C₂₁H₂₈O₄