| In vitro: |
| Eiyo to Shokuryo, 1977,30(5): 291-296. | | Studies on the Antioxidative Activities of Metabolites of Tryptophan.[Reference: WebLink] | Antioxidative effects of metabolites of tryptophan (Try) on the autoxidation of oil have been studied little.
METHODS AND RESULTS:
Present paper deals with the antioxidative activities of Try, kynurenine (Kyn), kynurenic acid (Ky. A), xanthorenic acid (Xa. A), anthranilic acid (An. A), 3 or 5-OH-anthranilic acid (3 or 5-OH-An. A), 5-OH-tryptamine (5-OH-Try. Am), Tryptamine hydrochloride (Try. Am-HCl), β-nicotinamide adenine dinucleotide (NAD) and alanine (Ala) using A.O.M., oven test, weighing method test and DPPH method (1, 1-diphenyl-2-picrilhydrozil).
The results obtained were as follows;
1) 3-OH-An. A was the most effective and followed by 5-OH-An. A, Ala, NAD>An. A, Try, Ky. A, Xa. A in decreasing order.
2) 5-OH-An. A showed great antioxidant activity at the concentration of 0.003% by A.O.M. test.
3) Mixture of 3-OH-An. A, 5-OH-An. A, Ala and Ala-NAD was more effective than each of them.
4) The mixture of tocopherol and Try or 5-OH-An. A had a greater antioxidative activity than tocopherol or 5-OH-An. A.
5) When oil was heated for 10hr, antioxidative activity of 5-OH-An. A was decreased, but tocopherol still kept the activity. |
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