Voleneol | CAS:70389-88-7 | Manufacturer ChemFaces

Voleneol

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Description:

1β,6α-Dihydroxyeudesm-4(15)-ene (Voleneol,DE) can attenuate the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells, it also can dose-dependently suppress the protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2),suggest thats DE may be a good candidate to regulate LPS-induced inflammatory response.

Targets:

NO | PGE | NOS | COX

In vitro:

Korean Journal of Pharmacognosy, 2015, 46(1): 12-6.

Anti-inflammatory effects of 1β‚6α-dihydroxyeudesm-4(15)-ene isolated from Myrrh on LPS-induced neuroinflammation in BV2 cells[Reference: WebLink]

Myrrh is a resinous substance obtained from Commiphora trees, which has long been used as an antiseptic agent.A sesquiterpene, 1β, 6α-dihydroxyeudesm-4(15)-ene (DE,Voleneol), was isolated from the hot water extract of Myrrh.
METHODS AND RESULTS:
In the presentstudy, we found that DE attenuates the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells. DE significantlyinhibited LPS-induced production of pro-inflammatory mediators such as nitric oxide (NO) and prostaglandin E2(PGE2) in BV2 microglia in a concentration-dependent manner without cytotoxic effect. Furthermore, DE dose-dependentlysuppressed the protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
CONCLUSIONS:
These results suggest that DE may be a good candidate to regulate LPS-induced inflammatory response.

Voleneol Description

Source:	The herbs of Curcuma wenyujin
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Voleneol
Price:
CAS No.:	70389-88-7
Catalog No.:	CFN97192
Molecular Formula:	C₁₅H₂₆O₂
Molecular Weight:	238.4 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Powder
Source:	The herbs of Curcuma wenyujin
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Sesquiterpenoids Compound Library PGE Inhibitor Library NOS Inhibitor Library NO Inhibitor Library COX Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.1946 mL	20.9732 mL	41.9463 mL	83.8926 mL	104.8658 mL
5 mM	0.8389 mL	4.1946 mL	8.3893 mL	16.7785 mL	20.9732 mL
10 mM	0.4195 mL	2.0973 mL	4.1946 mL	8.3893 mL	10.4866 mL
50 mM	0.0839 mL	0.4195 mL	0.8389 mL	1.6779 mL	2.0973 mL
100 mM	0.0419 mL	0.2097 mL	0.4195 mL	0.8389 mL	1.0487 mL

CFN89327	Eudesma-3,11-dien-2-one	86917-79-5	218.34	C₁₅H₂₂O
CFN96335	Beta-Rotunol	24405-57-0	234.3	C₁₅H₂₂O₂
CFN97192	Voleneol	70389-88-7	238.4	C₁₅H₂₆O₂
CFN99537	beta-Eudesmol	473-15-4	222.37	C₁₅H₂₆O
CFN96795	1beta-Hydroxy-beta-eudesmol	83217-89-4	238.37	C₁₅H₂₆O₂
CFN96161	Eudesm-4(15)-ene-3alpha,11-diol	113773-90-3	238.4	C₁₅H₂₆O₂
CFN96334	4-Hydroxy-11,12,13-trinor-5-eudesmen-7-one	133369-42-3	194.3	C₁₂H₁₈O₂
CFN96801	Oxyphyllenone A	363610-34-8	210.27	C₁₂H₁₈O₃
CFN97209	Ilicol	72715-02-7	238.4	C₁₅H₂₆O₂
CFN98698	Cryptomeridiol	4666-84-6	240.4	C₁₅H₂₈O₂