|A unique collection of 60 Toxicity natural compounds for screening|
|Catalog No:||Bb201|| Toxicity Compound Library
|Size:||1mg/well * 60 Compounds|
2mg/well * 60 Compounds
Dehydroabietic acid , a major poison to fishes in pulp and paper mill effluents, which could be useful in improving the diabetic wound healing, it can reverse several cell responses stimulated by TNF-α, including the activation of FOXO1 and the TGF-β1/Smad3 signaling pathway. Dehydroabietic acid derivatives displays antisecretory and antipepsin effect, have gastroprotective activity in the HCl/EtOH-induced gastric lesions in mice as well as for cytotoxicity in human lung fibroblasts (MRC-5) and human epithelial gastric (AGS) cells.
1. Echinulin has toxicity in rabbits.
Aconitine, one of the major Aconitum alkaloids, is a highly toxic compound from the Aconitum species, it appears to exert a long-lasting cholinergic action in the causation of severe arrhythmias leading to death.
1. Tetrodotoxin, a poison from the puffer fish, at very low concentrations, blocks the action potential production through its selective inhibition of the sodium-carrying mechanism while keeping the potassium-carrying mechanism intact.
2. Modulation of tetrodotoxin-resistant voltage-gated Na+ current (TTX-R INa) is a mechanism for sensitization of mammalian nociceptors.
Diosbulbin B has potential anti-tumor effects which may be related to influencing the immune system for the first time, it also exhibits potential hepatotoxicity.