- ChemFaces is a professional high-purity natural products manufacturer.
- Product Intended Use
- 1. Reference standards
- 2. Pharmacological research
- 3. Inhibitors
ChemFaces products have been cited in many studies from excellent and top scientific journals
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Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / Inquiry |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
- Appl. Sci. 2021, 11(17),7829
- Molecules.2020, 25(21):5091.
- Cancer Manag Res.2019, 11:483-500
- Chem Biol Interact.2019, 298:1-7
- Cytotechnology.2017, 69(5):765-773
- J Biochem Mol Toxicol.2022, e23211.
- Applied Biological Chemistry ...2021...
- Cells.2022, 11(8), 1311.
- J Pharm Anal.2016, 6(6):363-373
- Toxicol Res.2019, 35(4):371-387
- Biochem Biophys Res Commun....2018...
- Biomolecules.2020, 10(6):925.
- J Insect Sci.2020, 20(5):18.
- Cell Rep.2020, 32(11):108158.
- Journal of Functional Foods...2017...
- BioResources J.2020, 15(3).
- Int J Mol Sci.2021, 22(19):10405.
- Evid Based Complement Alternat Me...2015...
- RSC Advances2017, 86
- Vojnosanit Pregl2016, 75(00):391-391
- J Drug Target.2016, 24:1-28
- Molecules.2022, 27(21):7514.
- In Vitro Cellular & Developmental...2021...
- More...
Our products had been exported to the following research institutions and universities, And still growing.
- Utrecht University (Netherlands)
- Utah State University (USA)
- Universidad Veracuzana (Mexico)
- Harvard University (USA)
- Biotech R&D Institute (USA)
- The Ohio State University (USA)
- University of Wuerzburg (Germany)
- Chang Gung University (Taiwan)
- National Cancer Center Research... (Japan)
- Seoul National University of Sc... (Korea)
- Universidad de Antioquia (Colombia)
- More...
- Nutrients.2017, 10(1)
- Virulence.2018, 9(1):588-603
- Environ Toxicol.2022, 37(3):514-526.
- University of Limpopo2016, 1777
- Metab Eng.2022, 75:143-152.
- J Cell Mol Med.2018, 22(9):4236-4242
- Molecules.2020, 25(23):5556.
- Food Science and Biotechnology2015, 2205-2212
- J Sci Food Agric.2017, 97(5):1656-1662
- Acta Agriculturae Scandinavica2015, 381-383
Related Screening Libraries
| Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
|
| Description: |
5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone is a natural product from Broussonetia papyrifera. |
| In vitro: |
| Phytochemistry Letters, 2013, 6(3):331-336. | | Prenylflavone derivatives from Broussonetia papyrifera, inhibit the growth of breast cancer cells in vitro and in vivo.[Reference: WebLink] |
METHODS AND RESULTS:
Two new prenylflavones 5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone (1) and 5,7,3′,4′-tetrahydroxy-3-methoxy-8,5′-diprenylflavone (2), as well as four known ones, uralenol (3), papyriflavonol A (4), broussoflavonol B (5) and broussochalcone A (6) were isolated and purified from an ethyl acetate-soluble extract of the barks of Broussonetia papyrifera.
Their structures were determined with the spectroscopic methods including HR-EI-MS, 1D and 2D NMR. We found that compounds 2–6 showed potent anti-proliferation effects on ER-positive breast cancer MCF-7 cells in vitro. The IC50 values of compounds 2 and 5 were 4.41 and 4.19 μM respectively after the treatment of 72 h. We also found that compounds 2 and 5 strongly down-regulated expression concentrations of estrogen receptor-α (ER-α) and were able to inhibit tumor growth in a xenograft model of the human breast cancer line BCAP-37 in vivo.
CONCLUSIONS:
Our results demonstrated that prenylflavones from B. Papyrifera exhibit potent anti-tumor activity. |
|
5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone Description
| Source: |
The barks of Broussonetia papyrifera. |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.2099 mL |
11.0497 mL |
22.0994 mL |
44.1989 mL |
55.2486 mL |
| 5 mM |
0.442 mL |
2.2099 mL |
4.4199 mL |
8.8398 mL |
11.0497 mL |
| 10 mM |
0.221 mL |
1.105 mL |
2.2099 mL |
4.4199 mL |
5.5249 mL |
| 50 mM |
0.0442 mL |
0.221 mL |
0.442 mL |
0.884 mL |
1.105 mL |
| 100 mM |
0.0221 mL |
0.1105 mL |
0.221 mL |
0.442 mL |
0.5525 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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