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5,8-Epidioxyergosta-6,9(11),22-trien-3-ol
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 5,8-Epidioxyergosta-6,9(11),22-trien-3-ol
Price:
CAS No.: 86363-50-0
Catalog No.: CFN93118
Molecular Formula: C28H42O3
Molecular Weight: 426.63 g/mol
Purity: >=98%
Type of Compound: Steroids
Physical Desc.: Powder
Source: The fruitbody of Ganoderma lucidum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 5,8-Epidioxyergosta-6,9(11),22-trien-3-olshows cytotoxic activity, it was selectively cytotoxic to cancer cells.
In vitro:
Natural Product Research, 2016, 30(16):1-4.
Cytotoxic constituents of Lasiosphaera fenzlii on different cell lines and the synergistic effects with paclitaxel.[Reference: WebLink]

METHODS AND RESULTS:
The fruit body of Lasiosphaera fenzlii was found to show cytotoxicity on cancer cells during a preliminary screening. Repeated column chromatography of the fungal methanol extract resulted in the isolation of six compounds identified as 5α,8α-epidioxy-ergosta-6,22-dien-3β-ol (5,8-Epidioxyergosta-6,9(11),22-trien-3-ol,1), 5α,8α-epidioxy-ergosta-6,9(11),22-trien-3β-ol (2), 5α-ergosta-7,22-dien-3β-ol (3), 5α-ergosta-7,22-dien-3-one (4), ergosta-7,22-dien-3β,5α,6β-triol (5) and 6-dihydroxy-2,3-dihydro-1H-isoindol-1-one (6).
CONCLUSIONS:
The two peroxide compounds, 1 and 2, showed cytotoxic activity and compound 1 was selectively cytotoxic to cancer cells. Furthermore, compound 1 synergised the cytotoxicity of paclitaxel on Hela cells by increasing intracellular accumulation of paclitaxel in cancer cells but not in normal cells.
5,8-Epidioxyergosta-6,9(11),22-trien-3-ol Description
Source: The fruitbody of Ganoderma lucidum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.344 mL 11.7198 mL 23.4395 mL 46.879 mL 58.5988 mL
5 mM 0.4688 mL 2.344 mL 4.6879 mL 9.3758 mL 11.7198 mL
10 mM 0.2344 mL 1.172 mL 2.344 mL 4.6879 mL 5.8599 mL
50 mM 0.0469 mL 0.2344 mL 0.4688 mL 0.9376 mL 1.172 mL
100 mM 0.0234 mL 0.1172 mL 0.2344 mL 0.4688 mL 0.586 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Phytochemistry,1993,32(6):1549-1551
Steroids of formosan Ganoderma amboinense[Reference: WebLink]

METHODS AND RESULTS:
A new polyhydroxyl steroid and a new lanostanoid, named ganoderic acid AM1, together with the known steroids ergosta-7,22-dien-3β-ol, ergosta-7,22-dien-3β-yl linoleate, ergosterol peroxide, ergosta-7,22-dien-3β-yl palmitate, 2 β,3 α,9 α-trihydroxyergosta-7,22-diene, 5α, 8α-epidioxyergosta-6,9(11),22-trien-3β-ol(5,8-Epidioxyergosta-6,9(11),22-trien-3-ol ), and lucidone A have been isolated from Formosan Ganoderma amboinense.
CONCLUSIONS:
The new steroid and ganoderic acid AM 1 were characterized as 2β-methoxyl-3α, 9α-dihydroxyergosta-7,22-diene and 3β-hydroxy-7,11,15,23-tetraoxo- lanosta-8-en-26-oic acid, respectively.
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