7-Epi-10-deacetyltaxol | CAS:78454-17-8

7-Epi-10-deacetyltaxol

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Description:

7-Epi-10-deacetyltaxol shows IC50 values of 0.085 nM, against HeLa cells.

In vitro:

J Nat Prod. 2017 Apr 28;80(4):1087-1095.

α-Glucosidase Inhibitory and Cytotoxic Taxane Diterpenoids from the Stem Bark of Taxus wallichiana.[Pubmed: 28240909]

From a CH2Cl2 extract of the bark of Taxus wallichiana, six new taxoids, wallitaxanes A-F (1-6), were isolated, together with 29 known compounds.
METHODS AND RESULTS:
The structures of the new compounds were elucidated on the basis of spectroscopic data interpretation. Wallitaxane D (4) was identified as an opened oxetane-type taxoid having the first naturally occurring C(H)-20 acetal group, while wallitaxanes E (5) and F (6) are representative of the rare abeo-taxoid class. The isolated compounds were evaluated for their α-glucosidase inhibitory activity and for cytotoxicity against the HeLa human cervical cancer cell line.
CONCLUSIONS:
In the present work, taxanes were found to exhibit α-glucosidase inhibitory activity for the first time, and wallitaxane A (1) showed the most potent effect, with an IC50 value of 3.6 μM. In turn, 7-epi-taxol (16) and 7-Epi-10-deacetyltaxol (17) showed IC50 values of 0.05 and 0.085 nM, respectively, against HeLa cells.

7-Epi-10-deacetyltaxol Description

Source:	The barks of Taxus wallichiana.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Biomed Chromatogr. 2009 Jan;23(1):63-70.

Simultaneous determination of main taxoids in Taxus needles extracts by solid-phase extraction-high-performance liquid chromatography with pentafluorophenyl column.[Pubmed: 18816506 ]

METHODS AND RESULTS:
A simple and accurate RP-HPLC method with pentafluorophenyl (PFP) column was developed for the simultaneous determination of six taxoids, i.e. paclitaxel, 10-deacetylbaccatin III (10-DAB III), 7-xylosyl-10-deacetyltaxol (7-xyl-10-DAT), 10-deacetyltaxol (10-DAT), cephalomannine and 7-Epi-10-deacetyltaxol (7-epi-10-DAT), in the extracts from the needles of three Taxus species. The mobile phase consisted of acetonitrile (A) and water (B), and the extracts were separated using gradient elution program: 30% A at the first 7 min, and then ramped to 42% A at 8 min, held until 38 min. The developed method was validated with satisfactory precision (RSD < 2.61%), repeatability (RSD < 2.92%) and recovery (95.19-104.47%). The above taxoids in the extracts of Taxus cuspidata, T. chinensis and T. media were analyzed with the developed RP-HPLC method, and the results showed that the contents of different taxoids in three mentioned species were distinct. Maximal amounts of 10-DAB III, 7-xyl-10-DAT and 7-epi-10-DAT appeared in T. chinensis, while T. media possessed the highest content of 10-DAT, cephalomannine and paclitaxel. The developed method is accurate and efficient.
CONCLUSIONS:
It can be reliably used in the improved determination of taxoids for the quality control of Taxus species.

Product Name	7-Epi-10-deacetyltaxol
Price:	$80 / 20mg
CAS No.:	78454-17-8
Catalog No.:	CFN89397
Molecular Formula:	C₄₅H₄₉NO₁₃
Molecular Weight:	811.86 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The barks of Taxus wallichiana.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Diterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.2317 mL	6.1587 mL	12.3174 mL	24.6348 mL	30.7935 mL
5 mM	0.2463 mL	1.2317 mL	2.4635 mL	4.927 mL	6.1587 mL
10 mM	0.1232 mL	0.6159 mL	1.2317 mL	2.4635 mL	3.0793 mL
50 mM	0.0246 mL	0.1232 mL	0.2463 mL	0.4927 mL	0.6159 mL
100 mM	0.0123 mL	0.0616 mL	0.1232 mL	0.2463 mL	0.3079 mL

CFN89398	7-Xylosyltaxol B	90352-19-5	964.01	C₅₀H₆₁NO₁₈
CFN96640	Taxcultine	153415-46-4	819.90	C₄₄H₅₃NO₁₄
CFN89043	N-Methyltaxol C	153083-53-5	861.97	C₄₇H₅₉NO₁₄
CFN96633	Taxol C	153415-45-3	847.95	C₄₆H₅₇NO₁₄
CFN89385	7-Xylosyl-10-deacetyltaxol C	90332-65-3	938.02	C₄₉H₆₃NO₁₇
CFN89044	13-O-Cinnamoylbaccatin III	220932-65-0	716.77	C₄₀H₄₄O₁₂
CFN89140	Cabazitaxel intermediate	1354900-65-4	926.02	C₅₁H₅₉NO₁₅
CFN98517	Docetaxel	114977-28-5	807.88	C₄₃H₅₃NO₁₄
CFN98516	N-Debenzoyl-N-(tert-butoxycarbonyl)taxol	125354-16-7	849.92	C₄₅H₅₅NO₁₅
CFN98518	Cephalomannine	71610-00-9	831.91	C₄₅H₅₃NO₁₄