Epieriocalyxin A | CAS:191545-24-1 | Manufacturer ChemFaces

Epieriocalyxin A

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Description:

Epieriocalyxin A can suppress Caco-2 colon cancer cell growth, it could be a potential drug for colon cancer therapy in the future.

Targets:

ROS | JNK | ERK | Caspase | Bcl-2/Bax | DNA/RNA Synthesis

In vitro:

Cell Biochem Biophys. 2015 Nov;73(2):559-564.

Epieriocalyxin A Induces Cell Apoptosis Through JNK and ERK1/2 Signaling Pathways in Colon Cancer Cells[Pubmed: 27352353]

Colorectal cancer is one of the most commonly diagnosed cancers in the world. Currently, drug resistance of cancer cell to chemotherapy is a major cause for cancer recurrence and death of the patients; therefore, new therapeutic strategy is required to improve the care of colorectal cancer patients. The Chinese herb, Isodon eriocalyx, has been used a therapeutic for a long time in China.
METHODS AND RESULTS:
In this study, we showed that Epieriocalyxin A (EpiA), a diterpenoid isolated from I. eriocalyx, suppressed Caco-2 colon cancer cell growth. EpiA induced annexin V flipping in cell membrane and DNA fragment. We also showed that EpiA induced the generation of ROS in cells, as well as damage of the mitochondrial membrane. Western blot results showed that both JNK and ERK1/2 activation was decreased after EpiA treatment in a dose-dependent manner. EpiA increased the expression of caspase 3 and Bax, and decreased Bcl2 expression.
CONCLUSIONS:
Our results suggest that EpiA is a novel compound that induces colon cancer apoptosis. EpiA could be a potential drug for colon cancer therapy in the future.

Epieriocalyxin A Description

Source:	The herbs of Isodon eriocalyx
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Epieriocalyxin A
Price:
CAS No.:	191545-24-1
Catalog No.:	CFN99886
Molecular Formula:	C₂₀H₂₄O₅
Molecular Weight:	344.4 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The herbs of Isodon eriocalyx
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Diterpenoids Compound Library ROS Inhibitor Library JNK Inhibitor Library ERK Inhibitor Library DNA/RNA Synthesis Inhibitor Library Caspase Inhibitor Library Bcl-2/Bax Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9036 mL	14.518 mL	29.036 mL	58.072 mL	72.59 mL
5 mM	0.5807 mL	2.9036 mL	5.8072 mL	11.6144 mL	14.518 mL
10 mM	0.2904 mL	1.4518 mL	2.9036 mL	5.8072 mL	7.259 mL
50 mM	0.0581 mL	0.2904 mL	0.5807 mL	1.1614 mL	1.4518 mL
100 mM	0.029 mL	0.1452 mL	0.2904 mL	0.5807 mL	0.7259 mL

CFN97416	Trichorabdal A	85329-59-5	346.4	C₂₀H₂₆O₅
CFN92433	Isodonal	16964-56-0	404.5	C₂₂H₂₈O₇
CFN92261	6-epi-Augustifolin	369390-94-3	376.5	C₂₁H₂₈O₆
CFN98721	Sculponeatin K	477529-70-7	346.4	C₂₀H₂₆O₅
CFN92263	Lushanrubescensin H	476640-22-9	390.5	C₂₂H₃₀O₆
CFN92316	Maoyecrystal E	675603-39-1	406.5	C₂₂H₃₀O₇
CFN91482	Rabdophyllin G	82460-75-1	406.5	C₂₂H₃₀O₇
CFN92264	Rabdosin B	84304-92-7	448.5	C₂₄H₃₂O₈
CFN92312	Acetylexidonin	116368-90-2	490.6	C₂₆H₃₄O₉
CFN99886	Epieriocalyxin A	191545-24-1	344.4	C₂₀H₂₄O₅