Isopedicin | CAS:4431-42-9 | Manufacturer ChemFaces

Isopedicin

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Isopedicin Description

Source:	The herbs of Fissistigma oldhamii
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Free Radic Biol Med. 2009 Feb 15;46(4):520-8.

Potent inhibition of superoxide anion production in activated human neutrophils by isopedicin, a bioactive component of the Chinese medicinal herb Fissistigma oldhamii.[Pubmed: 19100830 ]

Fissistigma oldhamii is widely used in traditional Chinese medicine to treat rheumatoid arthritis. Activation of neutrophils is a key feature of inflammatory diseases. Herein, the anti-inflammatory functions of Isopedicin, a flavanone derived from F. oldhamii, and its underlying mechanisms were investigated in human neutrophils.
METHODS AND RESULTS:
Isopedicin potently and concentration-dependently inhibited superoxide anion (O(2)(*)(-)) production in formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP)-activated human neutrophils with an IC(50) value of 0.34+/-0.03 microM. Furthermore, Isopedicin displayed no superoxide-scavenging ability, and it failed to alter subcellular NADPH oxidase activity. The inhibitory effect of Isopedicin on O(2)(*)(-) production was reversed by protein kinase A (PKA) inhibitors. Moreover, Isopedicin increased cAMP formation and PKA activity in FMLP-activated human neutrophils, which occurred through the inhibition of phosphodiesterase (PDE) activity but not an increase in adenylate cyclase function. In addition, Isopedicin reduced FMLP-induced phosphorylation of extracellular regulated kinase and c-Jun N-terminal kinase, which was reversed by the PKA inhibitor. In contrast, Isopedicin failed to alter FMLP-induced phosphorylation of p38 mitogen-activated protein kinase and calcium mobilization.
CONCLUSIONS:
In summary, these results demonstrate that inhibition of O(2)(*)(-) production in human neutrophils by Isopedicin is associated with an elevation of cellular cAMP and activation of PKA through its inhibition of cAMP-specific PDE.

Product Name	Isopedicin
Price:
CAS No.:	4431-42-9
Catalog No.:	CFN97739
Molecular Formula:	C₁₈H₁₈O₆
Molecular Weight:	330.34 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Cryst.
Source:	The herbs of Fissistigma oldhamii
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Flavonoids Compound Library PKA Inhibitor Library PDE Inhibitor Library p38MAPK Inhibitor Library NADPH-oxidase Inhibitor Library JNK Inhibitor Library cAMP Inhibitor Library

Description:	Isopedicin has anti-inflammatory functions, it inhibits the O(2)(*)(-) production in human neutrophils by an elevation of cellular cAMP and activation of PKA through its inhibition of cAMP-specific PDE.
Targets:	PKA \| cAMP \| PDE \| p38MAPK \| NADPH-oxidase \| JNK

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.0272 mL	15.1359 mL	30.2718 mL	60.5437 mL	75.6796 mL
5 mM	0.6054 mL	3.0272 mL	6.0544 mL	12.1087 mL	15.1359 mL
10 mM	0.3027 mL	1.5136 mL	3.0272 mL	6.0544 mL	7.568 mL
50 mM	0.0605 mL	0.3027 mL	0.6054 mL	1.2109 mL	1.5136 mL
100 mM	0.0303 mL	0.1514 mL	0.3027 mL	0.6054 mL	0.7568 mL

CFN95580	8-Hydroxy-5,7-dimethoxyflavanone	201230-40-2	300.3	C₁₇H₁₆O₅
CFN97739	Isopedicin	4431-42-9	330.34	C₁₈H₁₈O₆
CFN94487	7-Hydroxyflavanone	6515-36-2	240.26	C₁₅H₁₂O₃
CFN98740	Pinocembrin	480-39-7	256.3	C₁₅H₁₂O₄
CFN99096	Pinocembrin 7-acetate	109592-60-1	298.3	C₁₇H₁₄O₅
CFN99211	Pinocembrin diacetate	111441-88-4	340.3	C₁₉H₁₆O₆
CFN98739	Pinostrobin	480-37-5	270.3	C₁₆H₁₄O₄
CFN98489	Alpinetin	36052-37-6	270.3	C₁₆H₁₄O₄
CFN92662	5,7-Dimethoxyflavanone	1036-72-2	284.3	C₁₇H₁₆O₄
CFN90899	(2R)-5,7-Dimethoxyflavanone	1277188-85-8	284.31	C₁₇H₁₆O₄