Kaempferol-3-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranosyl-(1->2)-beta-D-glucopyranoside | CAS:476617-49-9

Kaempferol-3-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranosyl-(1->2)-beta-D-glucopyranoside

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Product Name	Kaempferol-3-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranosyl-(1->2)-beta-D-glucopyranoside
Price:	$358 / 10mg
CAS No.:	476617-49-9
Catalog No.:	CFN91162
Molecular Formula:	C₃₃H₄₀O₂₀
Molecular Weight:	756.7 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The roots of Helicia erratica Hook. f.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
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Size /Price /Stock	10 mM * 1 mL in DMSO / $273.5 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Kaempferol-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside shows antioxidant activity.

In vivo:

PLoS One. 2014 Jun 3;9(6):e98559.

Isolation of antiosteoporotic compounds from seeds of Sophora japonica.[Pubmed: 24892557 ]

Chemical investigation of Sophora japonica seeds resulted in the isolation of seven metabolites identified as: genistin (1), sophoricoside (2), sophorabioside (3), sophoraflavonoloside (4), genistein 7,4'-di-O-β-D-glucopyransoide (5), Kaempferol-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside (6) and rutin (7). Compounds 1, 2 and 5 showed significant estrogenic proliferative effect in MCF-7 cell in sub-cytotoxic concentration range. Compounds 1 and 2 showed minimal cell membrane damaging effect using LDH leakage assay. Accordingly, compound 2 (sophoricoside, (SPH)) was selected for further in-vivo studies as a potential anti-osteoporosis agent. The anti-osteoporotic effect of SPH was assessed in ovarectomized (OVX) rats after oral administration (15 mg/kg and 30 mg/kg) for 45 days compared to estradiol (10 µg/kg) as a positive control. Only in a dose of 30 mg/kg, SPH regained the original mechanical bone hardness compared to normal non-osteoporotic group. However, SPH (15 mg/kg) significantly increased the level of alkaline phosphatase (ALP) to normal level. Treatment with SPH (30 mg/kg) increased the level of ALP to be higher than normal group. SPH (15 mg/kg) did not significantly increase the serum level of osteocalcin (OC) compared to OVX group. On the other hand, treatment with SPH (30 mg/kg) significantly increased the level of OC to 78% higher than normal non-ovarectomized animals group. In addition, SPH (15 mg/kg) decreased the bone resorption marker, acid phosphatase (ACP) to normal level and SPH (30 mg/kg) further diminished the level of serum ACP.
CONCLUSIONS:
Histopathologically, sophoricoside ameliorated the ovarectomy induced osteoporosis in a dose dependent manner. The drug showed thicker bony trabeculae, more osteoid, and more osteoblastic rimming compared to OVX group.

Kaempferol-3-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranosyl-(1->2)-beta-D-glucopyranoside Description

Source:	The roots of Helicia erratica Hook. f.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

J Asian Nat Prod Res. 2002 Jun;4(2):123-8.

Isolation and identification of antioxidants from Sophora japonica.[Pubmed: 12067157 ]

METHODS AND RESULTS:
A new flavonol triglycoside, Kaempferol-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside (1), as well as two known kaempferol 3-O-[alpha-L-rhamnopyranosyl-(1 --> 6)]-[beta-D-glucopyranosyl-(1 --> 2)]-beta-D-glucopyranoside (2) and kaempferol 3-O-beta-D-glucopyranosyl-(1 --> 2)-beta-D-glucopyranoside-7-O-alpha-L-rhamnopyranoside (3), were isolated from the n-BuOH extract of the pericarps of Sophora japonica by bioassay-guided fractionation. The structure of compound 1 was established by UV, IR, MS, and one- and two-dimensional NMR spectroscopy, including DEPT, NOESY, DQF-COSY, TOCSY, HMQC, and HMBC experiments.
CONCLUSIONS:
Compounds 1-3 showed antioxidative activity in DPPH and cytochrome-c assay using HL-60 cell system.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Flavonoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.3215 mL	6.6076 mL	13.2153 mL	26.4306 mL	33.0382 mL
5 mM	0.2643 mL	1.3215 mL	2.6431 mL	5.2861 mL	6.6076 mL
10 mM	0.1322 mL	0.6608 mL	1.3215 mL	2.6431 mL	3.3038 mL
50 mM	0.0264 mL	0.1322 mL	0.2643 mL	0.5286 mL	0.6608 mL
100 mM	0.0132 mL	0.0661 mL	0.1322 mL	0.2643 mL	0.3304 mL

CFN93559	Camelliaside A	135095-52-2	756.66	C₃₃H₄₀O₂₀
CFN91161	Plantanone B	55780-30-8	756.7	C₃₃H₄₀O₂₀
CFN96532	Kaempferol 3-O-rhamninoside	83170-31-4	740.66	C₃₃H₄₀O₁₉
CFN95134	Rhamnocitrin 3-glucoside	41545-37-3	462.4	C₂₂H₂₂O₁₁
CFN95474	Rhamnocitrin 3-galactoside	99878-05-4	462.4	C₂₂H₂₂O₁₁
CFN95491	Oxytroflavoside D	1391144-83-4	606.5	C₂₈H₃₀O₁₅
CFN96538	Catharticin	39723-40-5	754.69	C₃₄H₄₂O₁₉
CFN95489	Oxytroflavoside F	1391144-85-6	608.6	C₂₈H₃₂O₁₅
CFN98415	Kaempferol 3-neohesperidoside	32602-81-6	594.5	C₂₇H₃₀O₁₅
CFN92372	Kaempferol 3-O-beta-sophoroside	19895-95-5	610.5	C₂₇H₃₀O₁₆