Magnoloside A | CAS:113557-95-2 | Manufacturer ChemFaces

Magnoloside A

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $172.2 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Magnoloside A has potent antifungal activities against various Cryptococcus strains with minimum inhibitory concentration values ranging from 1.0 to 4.0 ug/ml.

Targets:

Antifection

In vitro:

J Microbiol Biotechnol. 2015 Sep;25(9):1429-32.

A Phenylpropanoid Glycoside as a Calcineurin Inhibitor Isolated from Magnolia obovata Thunb.[Pubmed: 26174771 ]

METHODS AND RESULTS:
To identify plant-derived cell signaling inhibitors with antifungal properties, a twocomponent screening system using both wild-type Cryptococcus neoformans and a calcineurin mutant was employed owing to their counter-regulatory actions on the Hog1 mitogenactivated protein kinase and calcineurin pathways. Of the 2,000 plant extracts evaluated, a single bioactive compound from M. obovata Thunb. was found to act specifically on the calcineurin pathway of C. neoformans.
CONCLUSIONS:
This compound was identified as Magnoloside A, and had potent antifungal activities against various Cryptococcus strains with minimum inhibitory concentration values ranging from 1.0 to 4.0 μg/ml.

Magnoloside A Description

Source:	The barks of Magnolia obovata.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

J Chromatogr Sci. 2015 Apr;53(4):598-602.

An HPLC-DAD Method for Simultaneous Quantitative Determination of Four Active Hydrophilic Compounds in Magnoliae Officinalis Cortex.[Pubmed: 25085894]

Magnoliae officinalis cortex (MOC), derived from Magnolia officinalis and its variation M. officinalis var. biloba, is an important traditional Chinese medicine.
METHODS AND RESULTS:
In our previous work, 11 hydrophilic ingredients of MOC were isolated and structurally elucidated and four, namely syringin (SG), Magnoloside A (MA), magnoloside B (MB) and magnoflorine (MF), showed bioactive effects. Herein, we describe an HPLC-DAD method for the simultaneous quantitative determination of MA, MB, MF and SG in MOC for the first time. The chromatographic separation of samples was performed on an Agilent Zorbax SB-C18 column (250 × 4.6 mm i.d., 5 µm) by gradient elution with water-acetic acid (pH 3.0) and methanol at a flow rate of 1.0 mL/min. The wavelengths were set at 265 nm for MF and SG, and 328 nm for MA and MB. The average recovery of the four compounds was from 97.63 to 103.84%. Nearly 100 MOC samples harvested from eight habitats were analyzed in which the contents of the tested compound varied in the range of 0.016-0.350% (MF), 0.010-0.337% (SG), 0.017-3.009% (MB) and 0.077-2.529% (MA).
CONCLUSIONS:
The analysis also indicated that MOC contains a significant amount of phenylethanoid glycosides. This was an unexpected finding because previously lignan was considered to be the main component of MOC.

Product Name	Magnoloside A
Price:	$268 / 10mg
CAS No.:	113557-95-2
Catalog No.:	CFN99232
Molecular Formula:	C₂₉H₃₆O₁₅
Molecular Weight:	624.6 g/mol
Purity:	>=98%
Type of Compound:	Phenylpropanoids
Physical Desc.:	Powder
Source:	The barks of Magnolia obovata.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antifungal Compound Library Phenylpropanoids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.601 mL	8.0051 mL	16.0102 mL	32.0205 mL	40.0256 mL
5 mM	0.3202 mL	1.601 mL	3.202 mL	6.4041 mL	8.0051 mL
10 mM	0.1601 mL	0.8005 mL	1.601 mL	3.202 mL	4.0026 mL
50 mM	0.032 mL	0.1601 mL	0.3202 mL	0.6404 mL	0.8005 mL
100 mM	0.016 mL	0.0801 mL	0.1601 mL	0.3202 mL	0.4003 mL

CFN89035	Hemiphroside B nonaacetate	132302-25-1	1060.98	C₄₉H₅₆O₂₆
CFN99705	Forsythoside A	79916-77-1	624.59	C₂₉H₃₆O₁₅
CFN90988	Forsythoside I	1177581-50-8	624.59	C₂₉H₃₆O₁₅
CFN90770	Tenuifoliside A	139726-35-5	682.6	C₃₁H₃₈O₁₇
CFN90578	3,6'-Disinapoyl sucrose	139891-98-8	754.68	C₃₄H₄₂O₁₉
CFN95298	Sibiricose A4	241125-73-5	754.7	C₃₄H₄₂O₁₉
CFN93305	3-Feruloyl-1-Sinapoyl sucrose	98942-06-4	724.66	C₃₃H₄₀O₁₈
CFN95294	Securoside A	107172-40-7	694.6	C₃₂H₃₈O₁₇
CFN95681	Vanicoside B	155179-21-8	956.9	C₄₉H₄₈O₂₀
CFN95696	Lapathoside A	373646-49-2	986.9	C₅₀H₅₀O₂₁