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RA VII
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name RA VII
Price:
CAS No.: 86229-97-2
Catalog No.: CFN92604
Molecular Formula: C41H50N6O9
Molecular Weight: 770.9 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The roots of Rubia cordifolia
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: RA VII is an antitumour agent, shows cytotoxic activity against P-388 cells. RA VII causes the conformational change of F-actin and the stabilization of actin filaments to induce G2 arrest.
In vitro:
Cancer Lett. 2004 Jun 25;209(2):223-9.
RA-VII, a cyclic depsipeptide, changes the conformational structure of actin to cause G2 arrest by the inhibition of cytokinesis.[Pubmed: 15159025 ]

METHODS AND RESULTS:
In L1210 cells, RA VII (0.1-100 nM) caused the concentration-dependent inhibition of the proliferation and G2 arrest. Treatment of PC12 cells with 10 nM RA VII changed cell shape round with binucleation, suggesting the inhibition of cytokinesis. The fluorescence intensity of FITC-phalloidin bound to F-actin was enhanced by RA VII. In surface plasmon resonance experiments, the signal of F-actin was modified by RA VII in close agreement with a concentration of FITC-phalloidin binding to F-actin.
CONCLUSIONS:
These results suggest that RA VII causes the conformational change of F-actin and the stabilization of actin filaments to induce G2 arrest.
RA VII Description
Source: The roots of Rubia cordifolia
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.2972 mL 6.4859 mL 12.9719 mL 25.9437 mL 32.4296 mL
5 mM 0.2594 mL 1.2972 mL 2.5944 mL 5.1887 mL 6.4859 mL
10 mM 0.1297 mL 0.6486 mL 1.2972 mL 2.5944 mL 3.243 mL
50 mM 0.0259 mL 0.1297 mL 0.2594 mL 0.5189 mL 0.6486 mL
100 mM 0.013 mL 0.0649 mL 0.1297 mL 0.2594 mL 0.3243 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Bioorg Med Chem Lett. 2013 Dec 15;23(24):6728-31.
Aza-cycloisodityrosine analogue of RA-VII, an antitumor bicyclic hexapeptide.[Pubmed: 24268554]
An aza-cycloisodityrosine analogue of RA-VII, 3, was designed and synthesized.
METHODS AND RESULTS:
The key aza-cycloisodityrosine unit was prepared by copper(II)-acetate-mediated intramolecular phenylamine/arylboronic acid coupling of dipeptide followed by connection with the tetrapeptide segment to afford a hexapeptide. Subsequent macrocyclization of the hexapeptide with EDC · HCl and HOOBt under dilute conditions gave 3. Analogue 3 showed significant cytotoxic activity against human promyelocytic leukemia HL-60 cells and human colon carcinoma HCT-116 cells, but its activity was weaker than that of parent peptide RA-VII (1).
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