RA VII | CAS:86229-97-2 | Manufacturer ChemFaces

RA VII

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Description:

RA VII is an antitumour agent, shows cytotoxic activity against P-388 cells. RA VII causes the conformational change of F-actin and the stabilization of actin filaments to induce G2 arrest.

In vitro:

Cancer Lett. 2004 Jun 25;209(2):223-9.

RA-VII, a cyclic depsipeptide, changes the conformational structure of actin to cause G2 arrest by the inhibition of cytokinesis.[Pubmed: 15159025 ]

METHODS AND RESULTS:
In L1210 cells, RA VII (0.1-100 nM) caused the concentration-dependent inhibition of the proliferation and G2 arrest. Treatment of PC12 cells with 10 nM RA VII changed cell shape round with binucleation, suggesting the inhibition of cytokinesis. The fluorescence intensity of FITC-phalloidin bound to F-actin was enhanced by RA VII. In surface plasmon resonance experiments, the signal of F-actin was modified by RA VII in close agreement with a concentration of FITC-phalloidin binding to F-actin.
CONCLUSIONS:
These results suggest that RA VII causes the conformational change of F-actin and the stabilization of actin filaments to induce G2 arrest.

RA VII Description

Source:	The roots of Rubia cordifolia
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Bioorg Med Chem Lett. 2013 Dec 15;23(24):6728-31.

Aza-cycloisodityrosine analogue of RA-VII, an antitumor bicyclic hexapeptide.[Pubmed: 24268554]

An aza-cycloisodityrosine analogue of RA-VII, 3, was designed and synthesized.
METHODS AND RESULTS:
The key aza-cycloisodityrosine unit was prepared by copper(II)-acetate-mediated intramolecular phenylamine/arylboronic acid coupling of dipeptide followed by connection with the tetrapeptide segment to afford a hexapeptide. Subsequent macrocyclization of the hexapeptide with EDC · HCl and HOOBt under dilute conditions gave 3. Analogue 3 showed significant cytotoxic activity against human promyelocytic leukemia HL-60 cells and human colon carcinoma HCT-116 cells, but its activity was weaker than that of parent peptide RA-VII (1).

Product Name	RA VII
Price:
CAS No.:	86229-97-2
Catalog No.:	CFN92604
Molecular Formula:	C₄₁H₅₀N₆O₉
Molecular Weight:	770.9 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The roots of Rubia cordifolia
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Cytotoxic Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.2972 mL	6.4859 mL	12.9719 mL	25.9437 mL	32.4296 mL
5 mM	0.2594 mL	1.2972 mL	2.5944 mL	5.1887 mL	6.4859 mL
10 mM	0.1297 mL	0.6486 mL	1.2972 mL	2.5944 mL	3.243 mL
50 mM	0.0259 mL	0.1297 mL	0.2594 mL	0.5189 mL	0.6486 mL
100 mM	0.013 mL	0.0649 mL	0.1297 mL	0.2594 mL	0.3243 mL

CFN92604	RA VII	86229-97-2	770.9	C₄₁H₅₀N₆O₉
CFN92605	RA-V	64725-24-2	756.9	C₄₀H₄₈N₆O₉
CFN92606	RA-XI	143277-27-4	814.9	C₄₂H₅₀N₆O₁₁
CFN97902	Enniatin B	917-13-5	639.8	C₃₃H₅₇N₃O₉
CFN97986	Enniatin B1	19914-20-6	653.9	C₃₄H₅₉N₃O₉
CFN91976	Methylpheophorbide A	5594-30-9	606.71	C₃₆H₃₈N₄O₅
CFN98204	Cytochalasin D	22144-77-0	507.6	C₃₀H₃₇NO₆
CFN70315	Cytochalasin C	22144-76-9	507.6	C₃₀H₃₇NO₆
CFN96781	Cytochalasin B	14930-96-2	479.61	C₂₉H₃₇NO₅