Science | Nature | Cell | View More
Natural Products
Sophoraisoflavone A
Sophoraisoflavone A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Sophoraisoflavone A
Price: $318 / 5mg
CAS No.: 117204-81-6
Catalog No.: CFN96513
Molecular Formula: C20H16O6
Molecular Weight: 352.34 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The root exudates of white lupin.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $470.1 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Max-Planck-Insitut (Germany)
  • Institute of Bioorganic Chemist... (Poland)
  • Harvard University (USA)
  • Warszawski Uniwersytet Medyczny (Poland)
  • VIB Department of Plant Systems... (Belgium)
  • Massachusetts General Hospital (USA)
  • University of the Basque Country (Spain)
  • Universidade da Beira Interior (Germany)
  • Leibniz Institute of Plant Bioc... (Germany)
  • University of Sao Paulo (Brazil)
  • Guangzhou Institutes of Biomedi... (China)
  • More...
Package
Featured Products
Gentisic acid

Catalog No: CFN92451
CAS No: 490-79-9
Price: $40/20mg
Ginsenoside F4

Catalog No: CFN90757
CAS No: 181225-33-2
Price: $/mg
Plantamajoside

Catalog No: CFN99522
CAS No: 104777-68-6
Price: $100/20mg
Irigenin

Catalog No: CFN93276
CAS No: 548-76-5
Price: $118/20mg
Physcion

Catalog No: CFN98848
CAS No: 521-61-9
Price: $40/20mg
Kukoamine A

Catalog No: CFN93215
CAS No: 75288-96-9
Price: $ / mg
(+)-Gallocatechin

Catalog No: CFN99138
CAS No: 970-73-0
Price: $138/20mg
6-Prenylnaringenin

Catalog No: CFN92017
CAS No: 68236-13-5
Price: $268/10 mg
Octahydrocurcumin

Catalog No: CFN90584
CAS No: 36062-07-4
Price: $388/20mg
Diosmetin

Catalog No: CFN90210
CAS No: 520-34-3
Price: $30/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Sophoraisoflavone A is a potential MRP inhibitor; it is also an inhibitor of germ tube growth in the AM fungus Gigaspora margarita, it strongly inhibited germ tube growth at 1.25 ug/disc. Sophoraisoflavone A shows inhibitory effects on copper-induced protein oxidative modification of mice brain homogenate in vitro.
Targets: Antifection | MRP
In vitro:
Phytochemistry. 2010 Nov;71(16):1865-71.
Lupin pyranoisoflavones inhibiting hyphal development in arbuscular mycorrhizal fungi.[Pubmed: 20813384]

METHODS AND RESULTS:
White lupin (Lupinus albus L.), a non-host plant for arbuscular mycorrhizal (AM) fungi in the typically mycotrophic family Fabaceae, has been investigated for root metabolites that inhibit hyphal development in AM fungi. Four known pyranoisoflavones, licoisoflavone B (1), Sophoraisoflavone A (2), alpinumisoflavone (3) and 3'-hydroxy-4'-O-methylalpinumisoflavone (4), together with three previously unknown pyranoisoflavones, lupindipyranoisoflavone A (5), 10'-hydroxylicoisoflavone B (6) and 10'-hydroxySophoraisoflavone A (7) were isolated from the root exudates of white lupin as an inhibitor of germ tube growth in the AM fungus Gigaspora margarita.
CONCLUSIONS:
Pyranoisoflavones 1, 2 and 3 strongly inhibited germ tube growth at 0.63, 1.25 and 0.63 μg/disc, respectively. The remaining compounds 4-7 were either moderate or weak inhibitors that inhibited germ tube growth at concentrations higher than 10 μg/disc. Licoisoflavone B (1) and Sophoraisoflavone A (2) completely inhibited hyphal branching induced by a lupin strigolactone, orobanchyl acetate, in G. margarita at 0.16 and 0.63 μg/disc, respectively.
Biol Trace Elem Res. 2001 Aug;81(2):169-75.
Inhibitory effects of licoisoflavones A and B and sophoraisoflavone A of Sophra mooracroftiana Beth ex Baker on copper-ion-induced protein oxidative modification of mice brain homogenate, in vitro.[Pubmed: 11554397 ]

METHODS AND RESULTS:
We present the results of an in vitro investigation of the inhibitory effects of licoisoflavones A and B and Sophoraisoflavone A isolated from Sophra mooracroftiana BETH ex BAKER on copper-induced protein oxidative modification of mice brain homogenate in vitro. Although inhibitory effect of Sophoraisoflavone A was stronger than those of licoisoflavones A and B, genistein as a related isoflavone, and mannitol as a hydroxy radical scavenger, inhibitory effects of licoisoflavones A and B were weaker than those of genistein and mannitol.
CONCLUSIONS:
These results demonstrated that the difference of inhibitory effects are dependent on the relation between chemical structures of these isoflavones, such as hydroxy group or benzopyran, and oxidative stress.
Sophoraisoflavone A Description
Source: The root exudates of white lupin.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Ephedrannin A

Catalog No: CFN95579
CAS No: 82001-39-6
Price: $318/5mg
Rhamnocitrin 3-galactoside

Catalog No: CFN95474
CAS No: 99878-05-4
Price: $318/10mg
Isospinosin

Catalog No: CFN95350
CAS No: 89701-83-7
Price: $318/5mg
Protocatechuic acid 4-O-beta-gluco...

Catalog No: CFN95557
CAS No: 7361-59-3
Price: $413/5mg
Eucomic acid

Catalog No: CFN95364
CAS No: 42151-32-6
Price: $368/5mg
Otobaphenol

Catalog No: CFN95476
CAS No: 10240-16-1
Price: $318/10mg
2',4'-Dihydroxychalcone

Catalog No: CFN95493
CAS No: 1776-30-3
Price: $318/20mg
8-Hydroxypinoresinol-4'-O-beta-D-g...

Catalog No: CFN95356
CAS No: 102582-69-4
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8382 mL 14.1908 mL 28.3817 mL 56.7634 mL 70.9542 mL
5 mM 0.5676 mL 2.8382 mL 5.6763 mL 11.3527 mL 14.1908 mL
10 mM 0.2838 mL 1.4191 mL 2.8382 mL 5.6763 mL 7.0954 mL
50 mM 0.0568 mL 0.2838 mL 0.5676 mL 1.1353 mL 1.4191 mL
100 mM 0.0284 mL 0.1419 mL 0.2838 mL 0.5676 mL 0.7095 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Blood Cells Mol Dis. 2001 Sep-Oct;27(5):894-900.
Monitoring of MRP-like activity in human erythrocytes: inhibitory effect of isoflavones.[Pubmed: 11783953 ]

METHODS AND RESULTS:
A method to fluorometrically monitor efflux of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein (BCPCF) from human erythrocytes was developed. Genistein, daidzein, Sophoraisoflavone A, and licoisoflavone A induced 50% inhibition (IC(50)) of BCPCF efflux at 15-70 microM. The IC(50) value of the most efficient isoflavone, licoisoflavone A (15-25 microM), was comparable to that of indomethacin (approximately 10 microM) and markedly lower than for probenecid (100-200 microM), both known MRP1 inhibitors.
CONCLUSIONS:
Our results indicate that the human erythrocyte is a useful cell model in screening potential MRP inhibitors, that BCPCF is a good substrate for MRP, and that some isoflavones at low concentrations inhibit MRP-mediated efflux.
Gentisic acid

Catalog No: CFN92451
CAS No: 490-79-9
Price: $40/20mg
Ginsenoside F4

Catalog No: CFN90757
CAS No: 181225-33-2
Price: $/mg
Plantamajoside

Catalog No: CFN99522
CAS No: 104777-68-6
Price: $100/20mg
Irigenin

Catalog No: CFN93276
CAS No: 548-76-5
Price: $118/20mg
Physcion

Catalog No: CFN98848
CAS No: 521-61-9
Price: $40/20mg
Kukoamine A

Catalog No: CFN93215
CAS No: 75288-96-9
Price: $ / mg
(+)-Gallocatechin

Catalog No: CFN99138
CAS No: 970-73-0
Price: $138/20mg
6-Prenylnaringenin

Catalog No: CFN92017
CAS No: 68236-13-5
Price: $268/10 mg
Octahydrocurcumin

Catalog No: CFN90584
CAS No: 36062-07-4
Price: $388/20mg
Diosmetin

Catalog No: CFN90210
CAS No: 520-34-3
Price: $30/20mg
Tags: buy Sophoraisoflavone A | Sophoraisoflavone A supplier | purchase Sophoraisoflavone A | Sophoraisoflavone A cost | Sophoraisoflavone A manufacturer | order Sophoraisoflavone A | Sophoraisoflavone A distributor