Science | Nature | Cell | View More
Natural Products
Convolvine
Convolvine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Convolvine
Price:
CAS No.: 537-30-4
Catalog No.: CFN00186
Molecular Formula: C16H21NO4
Molecular Weight: 291.34 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Oil
Source: The herbs of genus Convolvulus.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Lund University (Sweden)
  • University of Toronto (Canada)
  • Funda??o Universitária de Dese... (Brazil)
  • Uniwersytet Gdański (Poland)
  • University of Zurich (Switzerland)
  • The University of Newcastle (Australia)
  • Texas A&M University (USA)
  • Auburn University (USA)
  • Nicolaus Copernicus Uniwersity (Poland)
  • FORTH-IMBB (Greece)
  • Uniwersytet Jagielloński w Kra... (Poland)
  • More...
Package
Featured Products
Sodium houttuyfonate

Catalog No: CFN90975
CAS No: 1847-58-1
Price: $50/20mg
Hydroxysafflor yellow A

Catalog No: CFN99950
CAS No: 78281-02-4
Price: $60/20mg
Jaceosidin

Catalog No: CFN90386
CAS No: 18085-97-7
Price: $168/20mg
Vitexin-2''-O-rhamnoside

Catalog No: CFN98177
CAS No: 64820-99-1
Price: $118/20mg
Isoscoparin-2''-Beta-D-glucopyrano...

Catalog No: CFN90900
CAS No: 97605-25-9
Price: $238/5mg
Hydroxygenkwanin

Catalog No: CFN98021
CAS No: 20243-59-8
Price: $118/20mg
Osthol

Catalog No: CFN98765
CAS No: 484-12-8
Price: $30/20mg
Physalin L

Catalog No: CFN90166
CAS No: 113146-74-0
Price: $288/5mg
Senkirkine

Catalog No: CFN00424
CAS No: 2318-18-5
Price: $ /
Salicylic acid

Catalog No: CFN93274
CAS No: 69-72-7
Price: $30/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Convolvine and its derivatives exhibit pronounced antihypoxic, immunomodulating, and anti-inflammatory activity, they exhibit cytotoxic activity, the alkaloids N-benzylconvolvine and N-chloroacetylconvolvine at concentrations of 10 ug/mL exhibit the greatest activity against HeLa and Hep cancer cell cultures. Convolvine blocks the M-receptors of the heart and intestine but raises the sensitivity of the M-receptors of the salivary gland and of the CNS,convolvine has revealed characteristics of a sedative and nootropic agent.
Targets: Immunology & Inflammation related
In vitro:
Chemistry of Natural Compounds,2011,47(4): 608-11.
Derivatives of the alkaloid convolvine and their pharmacological activity[Reference: WebLink]

METHODS AND RESULTS:
The alkaloid contents of Convolvulus subhirsutus and C. pseudocanthabrica growing in various regions of Uzbekistan, Kazakhstan, and Tadzhikistan were previously investigated and were found to include ~10 tropane alkaloids [ 1 , 2 ]. The alkaloid composition and content depended on the habitat. Thus, total alkaloids in C. subhirsutus growing in Uzbekistan was 0.6–0.75% (aerial part) and 0.6–1.6% (roots) [ 2 , 3 ]; in Tadzhikistan, 0.12%(aerial part) [ 4 ]. The main alkaloids in all plants were nortropine derivatives Convolvine ( 1 , 3,4-dimethoxybenzoyloxynortropane) and Convolamine (3,4-dimethoxybenzoyloxytropane), which amounted to 40–50% of the total. The alkylation and acylation of the NH group in 1 were studied [ 3 ].
CONCLUSIONS:
Preliminary tests showed that the synthesized compounds included some with pronounced antihypoxic, immunomodulating, and anti-inflammatory activity.
Chemistry of Natural Compounds, 2013,48(6):1039-41.
Synthesis of convolinine and cytotoxic activity of alkaloids of the genus Convolvulus and their derivatives[Reference: WebLink]
The minor base convolinine was synthesized.
METHODS AND RESULTS:
The activity of alkaloids from plants of the genus Convolvulus and their derivatives against HeLa and Hep cancer cell cultures and primary fibroblast culture was studied. It was found that the alkaloid Convolvine and its derivatives exhibited cytotoxic activity.
CONCLUSIONS:
The alkaloids N-benzylConvolvine (4) and N-chloroacetylConvolvine (5) at concentrations of 10 μg/mL exhibited the greatest activity against HeLa and Hep cancer cell cultures. The percent suppression of HeLa cervical carcinoma cells by alkaloid 4 was 35%; of Hep laryngeal cancer cells, 81.6%.
In vivo:
Chemistry of Natural Compounds,1998,34(1):56-8.
Neuro- and psychopharmacological investigation of the alkaloids convolvine and atropine[Reference: WebLink]
It has been established that Convolvine blocks the M-receptors of the heart and intestine but raises the sensitivity of the M-receptors of the salivary gland and of the CNS, while atropine blocks all the abovementioned M-receptors.
METHODS AND RESULTS:
Convolvine has revealed characteristics of a sedative and nootropic agent. Atropine, however, which is known as a psychomotor stimulator, prevents the realization of a conditioned gastromotor reflex. An analysis has been made of the relationship between features of the pharmacological activities and chemical structures of Convolvine and atropine.
Convolvine Description
Source: The herbs of genus Convolvulus.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
11-Keto-ganoderic acid DM

Catalog No: CFN95593
CAS No: N/A
Price: $413/5mg
10-Deacetylcephalomannine

Catalog No: CFN95519
CAS No: 76429-85-1
Price: $318/10mg
Fortunellin-6''-beta-D-glucopyrano...

Catalog No: CFN95315
CAS No: 1218774-64-1
Price: $318/5mg
Arganine B

Catalog No: CFN95281
CAS No: 144425-21-8
Price: $318/5mg
Bruceoside A

Catalog No: CFN95080
CAS No: 63306-30-9
Price: $318/10mg
4'-O-Methyllucenin II (Diosmetin 6...

Catalog No: CFN95344
CAS No: 98813-28-6
Price: $318/10mg
Methyl ganoderate F

Catalog No: CFN95584
CAS No: 98665-08-8
Price: $368/5mg
Methylpicraquassioside B

Catalog No: CFN95379
CAS No: 1443757-89-8
Price: $318/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.4324 mL 17.1621 mL 34.3242 mL 68.6483 mL 85.8104 mL
5 mM 0.6865 mL 3.4324 mL 6.8648 mL 13.7297 mL 17.1621 mL
10 mM 0.3432 mL 1.7162 mL 3.4324 mL 6.8648 mL 8.581 mL
50 mM 0.0686 mL 0.3432 mL 0.6865 mL 1.373 mL 1.7162 mL
100 mM 0.0343 mL 0.1716 mL 0.3432 mL 0.6865 mL 0.8581 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Sodium houttuyfonate

Catalog No: CFN90975
CAS No: 1847-58-1
Price: $50/20mg
Hydroxysafflor yellow A

Catalog No: CFN99950
CAS No: 78281-02-4
Price: $60/20mg
Jaceosidin

Catalog No: CFN90386
CAS No: 18085-97-7
Price: $168/20mg
Vitexin-2''-O-rhamnoside

Catalog No: CFN98177
CAS No: 64820-99-1
Price: $118/20mg
Isoscoparin-2''-Beta-D-glucopyrano...

Catalog No: CFN90900
CAS No: 97605-25-9
Price: $238/5mg
Hydroxygenkwanin

Catalog No: CFN98021
CAS No: 20243-59-8
Price: $118/20mg
Osthol

Catalog No: CFN98765
CAS No: 484-12-8
Price: $30/20mg
Physalin L

Catalog No: CFN90166
CAS No: 113146-74-0
Price: $288/5mg
Senkirkine

Catalog No: CFN00424
CAS No: 2318-18-5
Price: $ /
Salicylic acid

Catalog No: CFN93274
CAS No: 69-72-7
Price: $30/20mg
Tags: buy Convolvine | Convolvine supplier | purchase Convolvine | Convolvine cost | Convolvine manufacturer | order Convolvine | Convolvine distributor