Natural Products
| Catalog No. | Information |
| CFN99849 | Ethyl beta-D-fructofuranoside Ethyl beta-D-fructofuranoside shows positive anti-tumor cells migration effects. |
| CFN99850 | Quinovic acid 3-O-(3',4'-O-isopropylidene)-beta-D-fucopyranoside Reference standards. |
| CFN99903 | Sennoside A Sennoside A, a kind of irritant laxative isolated from rhei rhizome, causes purgative actions in the intestine, it and Sennoside B have protective effects on gastric lesion. Sennoside A also is a new dual HIV-1 inhibitor effective on HIV-1 replication. |
| CFN99904 | Sennoside B Sennoside B, a major purgative component, has a potential utility in the treatment of proliferative diseases, through inhibiting PDGF-stimulated cell proliferation by binding to PDGF-BB and its receptor and by down-regulating the PDGFR-beta signaling pathway. It and sennoside A also possess significant gastroprotective activities . |
| CFN99905 | Sennoside C Sennoside C , aloe-emodin anthrone and rhein anthrone which formed mainly by intraluminal bacterial action, synergistically exert their purgative effects on mice. |
| CFN99906 | Sennoside D Sennoside D is a natural product from Cassia angustifolia. |
| CFN99907 | Shikonin Shikonin is a natural red naphthoquinone pigment, has antimicrobial, anti-tumor, and anti-inflammatory effects; a purified shikonin preparation is widely used for the production of medicinals, cosmetics, and some food products; shikonin also enters into the antiinflammatory ointment and cream compositions used for the treatment of burns. It can suppress the cell viability, adhesion, invasion and migratory ability of MGC-803 cells through TLR2- or NF-κB-mediated pathway. |
| CFN99908 | Toosendanin Toosendanin (TSN) was used as a digestive tract-parasiticide and agricultural insecticide in ancient China;TSN is a selective presynaptic blocker, a L-type Ca 2+ channel agonist and an effective antibotulismic agent, by interfering with neurotransmitter release through an initial facilitation followed by a subsequent depression. TSN has effects on the growth, cell cycle arrest, induction of apoptosis and the involved signaling pathway in human promyelocytic leukemia HL-60 cells. |
| CFN99909 | Tetramethylpyrazine Tetramethylpyrazine has antiinflammatory, analgesic, antioxidant, antiplatelet, antitumor, hepatoprotective, and antiapoptosis activities. Tetramethylpyrazine exerts neuroprotective effect against hypoxia, it inhibits CoCl2 -induced neurotoxicity through enhancement of Nrf2/GCLc/GSH and suppression of HIF1α/NOX2/ROS pathways. It targeted HSCs via PDGF-βR/NLRP3/caspase1 pathway. |
| CFN99910 | Ligustrazine Hydrochloride Ligustrazine hydrochloride has antithrombotic effect, has certain protection effect on the vascular endothelium undergoing cardiopulmonary bypass (CPB), and can inhibit the activation of humai platelet following severe brain injury , improve t'ie balance, of TXA2 - PGI2 within the circulatory blood. It can exert down-regulate effects on Colon26 secretion of immunosuppressors and its tumor immunosuppression. |
| CFN99911 | D-(+)-Xylose A composition containing an effective amount of D-xylose, an ester thereof or an oligosaccharide containing D-xylose, in a combination with a cosmetically or pharmaceutically acceptable excipient. |
| CFN99912 | Asiaticoside Asiaticoside, a biochemical modulator, which has antioxidant, anti-inflammatory, antipyretic, anxiolytic-like, anti-gastric ulcers, hepatoprotective, and antidepressant-like effects, it also exhibits significant wound healing activity in normal as well as delayed healing models. Asiaticoside suppressed collagen expression and TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts. It and its derivatives can be regarded as reasonable candidates for a therapeutic Alzheimer's disease drug that protects neurons from Abeta toxicity. |
| CFN99913 | Madecassoside Madecassoside is a mechanism-based inhibitor of CYP2C19 and CYP3A4, which has antioxidant, anti-inflammatory, anti-apoptosis, wound-healing, and neuroprotective activities, It may have cardioprotective effects in LPS-mediated through inhibition of ERK, p38, and NF-κB activity, it inhibited the pro-inflammatory mediators, including COX-2 expression, PGE2 production, TNF-αand IL-6 levels and the up-regulation anti-inflammatory molecule IL-10. |
| CFN99914 | Madecassic acid Madecassic acid has anti-diabetic, anti- tumor, wound-healing, and anti-inflammatory properties, it can improve glycemic control and hemostatic imbalance, lower lipid accumulation, and attenuate oxidative and inflammatory stress in diabetic mice. It can protect against hypoxia-induced oxidative stress in retinal microvascular endothelial cells via ROS-mediated endoplasmic reticulum stress. It inhibited the esspession of NOS, COX-2, TNF-alpha, IL-1beta, IL-6, and the downregulation of NF-kappaB activation. |
| CFN99851 | Nyssoside Nyssoside may have anticancer activity. |
| CFN99852 | 3,4-O-Isopropylidene shikimic acid 3,4-Oxo- isopropylidene-shikimic acid has significant anti-inflammatory, anti-thrombosis, antioxidant, analgesic effects, it has protective effects on experimental colitis induced by trinitrobenzenesulfonic acid in rats, probably due to an antioxidant action. 3,4-Oxo-isopropylidene shikimic acid relieves the brain edema of rats subjected to MCAT by improving the energy metabolism and Na +, K +-ATPase activity in rat brain tissue. 3,4-Oxo-isopropylidene-shikimic acid has exhibited ameliorative effect on cognitive impairment in experimental animal models of dementia, it can promote adipogenesis by up-regulating expressions of C/EBP β, PPAR γ, C/EBP α, aP2 and FAS, and also stimulate adipokines during adipocyte differentiation, suggests that stimulation of adipokines and cognitive enhancing effect of 3,4-oxo-isopropylidene-shikimic acid have some relationship. |
| CFN99853 | Dimeric coniferyl acetate Dimeric coniferyl acetate has anti-inflammary activity, it shows strong NO inhibition with IC50 values of 27.1 uM in lipopolysacchalide (LPS)-activated murine macrophage-like J774.1 cells. It exhibits significant inhibitory effects on the nitric oxide production in lipopolysaccharide activated C57BL6/J mouse macrophages. |
| CFN99854 | Dihydromorin trans-Dihydromorin is an effective hypopigmenting agent in normal skin cells, hypopigmenting agents effective in melanoma system may not be effective on normal melanocytes, indicating that a non-tumor melanocyte system is more suitable for the screening of hypopigmenting agents. Dihydromorin shows strong mushroom inhibitory activity with IC50 values lower than 50 microM, more potent than (IC50 = 71.6 microM), it may be as an antibrowning agent in food systems. |
| CFN99855 | Taxinine B Taxinine and taxinine B can inhibit the drug transport by P-glycoprotein in multidrug-resistant cells. Taxinine B shows stronger inhibitory effects than acetylsalicylic acid (ASA) on platelet aggregation induced by arachidonic acid (AA). |
| CFN99856 | Mangostanol Mangostanol is an acetylcholinesterase (AChE) selective inhibitor.Mangostanol has anti-cancer activity, it shows significant activities against the CEM-SS cell line, with IC50 values of 9.6 microg/ml. |
| CFN99857 | Nigracin Reference standards. |
| CFN99858 | Loganin Loganin is a non-competitive inhibitor of BACE1 with IC50 of 47.97 μM an also inhibits AChE and BChE with IC50 values of 3.95 μM and 33.02 μM, respectively. Loganin has neuroprotective, anti-amnesic, anti-inflammatory and anti-shock effects, it also exhibits protective effects against hepatic injury and other diabetic complications associated with abnormal metabolic states and inflammation caused by oxidative stress and advanced glycation endproduct formation. Loganin can attenuate neuroinflammatory responses through the inactivation of NF-κB by NF-κB dependent inflammatory pathways and phosphorylation of MAPK in Aβ25-35-induced PC12 cells, and can protect against hydrogen peroxide-induced apoptosis by inhibiting phosphorylation of JNK, p38, and ERK 1/2 MAPKs in SH-SY5Y cells. |
| CFN99859 | Corchoionoside C Corchoionoside C has antioxidant activity, shows strong scavenging activities on DPPH radical, it also shows weak antifungal activity. Corchoionosides A, B, and C inhibit the histamine release from rat peritoneal exudate cells induced by antigen-antibody reaction. |
| CFN99860 | 2,3-Dihydroxypterodontic acid Reference standards. |
| CFN99861 | Pterodontic acid Pterodontic acid and pterodondiol showed moderate activity against bacteria including Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis. |
| CFN99862 | Echinulin Echinulin has toxicity in rabbits. |
| CFN99863 | enantio-7(11)-Eudesmen-4-ol Reference standards. |
| CFN99864 | Actein Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblasts in osteoporotic patients. Actein's ability to pathways involved in lipid disorders and carcinogenesis may make it a new agent for preventing and treating these major disorders, it has been shown to inhibit the proliferation of human breast cancer cells, by altering the activity of the ER IP3 receptor and Na,K-ATPase, inducing calcium release and modulating the NF-κB and MEK pathways. |
| CFN99865 | Methylisopelletierine N-Methylisopelletierine has hepatoprotective activity. |
| CFN99915 | Aconitine Aconitine, one of the major Aconitum alkaloids, is a highly toxic compound from the Aconitum species, it appears to exert a long-lasting cholinergic action in the causation of severe arrhythmias leading to death. |
| CFN99916 | Beta-Sitosterol Beta-Sitosterol is a novel plant-derived angiogenic factor which may have potential pharmaceutical applications for the management of chronic wounds. It has potent anti-inflammatory, anti-proliferation, and pro- apoptosis activities, it also possesses antipyretic activity, similar to acetylsalicylic acid. |
| CFN99917 | Capsaicin Capsaicin, the main pungent ingredient in 'hot' chilli peppers, is a TRPV1 agonist with EC50 of 0.29±0.05 μM in HEK293 cells, which elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system, it may used as a pain therapy by the long-lasting and inhibitory effects on persistent pain. Capsaicin has antioxidant activity , it is more effective than melatonin in suppressing the formation of lipid hydroperoxides, it also reduces anxiety-like behaviours in rats and may be an admissible drug candidate for treating endometriosis. |
| CFN99918 | Dihydrocapsaicin Dihydrocapsaicin, a potential inducer of autophagy, has cytotoxic activity. It has anti-atherogenic activity, can reduce the susceptibility of low-density lipoprotein (LDL) to oxidation. Dihydrocapsaicin treatment depletes peptidergic nerve fibers of substance P and alters mast cell density in the respiratory tract of neonatal sheep. |
| CFN99919 | Piperine Piperine, an inhibitor of human P-glycoprotein and/or CYP3A4, which has antinociceptive, antiarthritic, antidepressant, hepatoprotective, immunomodulatory , antitumor, anti-oxidative, anti-apoptotic, chemo-protective, and anti-inflammatoryactivities. Administration of piperine appears to reverse preexisting high-fat diet (HFD)-induced hepatic steatosis and insulin resistance, probably by activation of adiponectin-AMPK signalling. |
| CFN99920 | Tectorigenin Tectorigenin has hepatoprotective, antifibrotic, anti-leukemia, antioxidant, and anti-inflammatory activities, it could sensitize paclitaxel-resistant human ovarian cancer cells through inactivation of the Akt/IKK/IκB/NFκB signaling pathway, and promise a new intervention to chemosensitize paclitaxel-induced cytotoxicity in ovarian cancer. |
| CFN99921 | Tectoridin Tectoridin, an lens aldose reductase inhibitor, has several pharmacological effects including hypoglycemic, anti-cancer, anti-inflammatory, antioxidant, and hepatoprotectivy. It possesses a estrogenic and thyroid hormone-like agent by activating estrogen and thyroid hormone receptors, it also has inhibition on prostaglandin E2 production and cyclooxygenase-2 induction. |
| CFN99922 | Schizandrin A Schisandrin A , an agonist of the adiponectin receptor 2 (AdipoR2) with the IC50 value of 3.5 μM, has neuroprotective, anti-inflammatory, liver-protective, antitumor, and antioxidant activities. It alleviated microglia-mediated neuroinflammation injury through inhibiting the TRAF6-IKKβ-NF-κB and Jak2-Stat3 signaling pathways. It inhibited CYP3A activity with an IC50 of 6.60 μM and Ki of 5.83 μM, respectively. |
| CFN99923 | Schizandrin B Schisandrin B, a kind of ATR and P-gp inhibitor with high safety, has been shown to produce antioxidant effect on rodent liver and heart. It also has anti-photoaging, and presents promising activities for future development of protective agents against CisPt nephrotoxicity. Combination of schizandrin B and paclitaxel(PTX) can enhance anti-tumor effects and relieve side effects of PTX on rats with mammary carcinoma. |
| CFN99924 | Schisantherin B Schisantherin B may protect against cognitive deficits and neurodegeneration induced by Aβ1-42 in mice by regulating the glutamate transporter type 1 (GLT-1) restoration as well as the capacity of Glycogen synthase kinase3β(GSK3β), it also shows good effect in lowering the serum glutamic-pyruvic transaminase level of the patients suffering from chronic virus hepatitis. |
| CFN99925 | Schisantherin A Schisantherin A exhibits anti-tussive, sedative, anti-inflammatory, antioxidant, anti-osteoporotic, neuroprotective, cognition enhancing, and cardioprotective activities. Schisantherin A can significantly attenuate Aβ1-42-induced learning and memory impairment and noticeably improve the histopathological changes in the hippocampus. Schisantherin A exhibits neuroprotection against 1-methyl-4-phenylpyridinium ion (MPP(+)) through the regulation of two distinct pathways including increasing CREB-mediated Bcl-2 expression and activating PI3K/Akt survival signaling. |
| CFN99926 | Nicotinamide Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1, it has insulinotropic action, it can induce differentiation and maturation of human fetal pancreatic islet cells. Nicotinamide may represent a safe treatment for Alzheimer's disease and other tauopathies, and that phosphorylation of tau at Thr231 may regulate tau stability. |
| CFN99866 | Sitoindoside I Sitoindoside I has anti-ulcerogenic activity. |
| CFN99867 | Serpentine Reference standards. |
| CFN99868 | Odoroside H Odoroside H has anticancer activities, the cytotoxic effects are induced by the inhibition of the plasma membrane bound Na(+)/K(+)-ATPase. |
| CFN99869 | Massonianoside B Massonianoside B shows potent antioxidant activity. |
| CFN99870 | Melilotigenin C Reference standards. |
| CFN99871 | Byzantionoside B Byzantionoside B shows stimulatory activity on human osteoblast cells, it may have the potential to stimulate bone formation and regeneration. |
| CFN99872 | Cleroindicin C Cleroindicin C has anticancer activity. |
| CFN99873 | Cleroindicin D Reference standards. |
| CFN99874 | Cleroindicin F Cleroindicin F shows cytotoxic activity against some human cancer cells. Cleroindicin F and apigenin in the ethyl acetate extract provide scientific support to the traditional use of the leaves of C. splendens for the treatment of infections, wounds and other inflammatory conditions. |
