Natural Products
| Catalog No. | Information |
| CFN99781 | Griffonilide Griffonilide is islolated from the tubers of Tylosema esculentum (morama). |
| CFN99782 | Fraxinellone Fraxinellone is a selective blocker of voltage-dependent Ca2+ channel, which possesses antimicrobial, anti-inflammatory, neuroprotective and vasorelaxing activities, Fraxinellone exhibits a variety of insecticidal activities including feeding-deterrent activity, inhibition of growth, and larvicidal activity. It inhibited the production of iNOS, COX-2, NF-kappa B, and PGE(2). |
| CFN99783 | Dictamnine Dictamnine shows anticholinesterase, anti-inflammatory, mutagenic, and has antimicrobial activity against bacteria and fungi. It has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells, it at higher concentrations(≥100uM) has potential hepatotoxicity because of the cell membrane damage and mitochondrial membrane damage. |
| CFN99784 | Shionone Shionone has anti-inflammatory effect, the mechanism is related to decrease the phosphorylation level of ERK1/2 protein and IκBα and the protein expression of i NOS. It can inhibit the activity of ubiquitin-specific protease 2 (USP2) and provide a lead compound for future development of new USP2 inhibitors. |
| CFN99785 | Columbianadin Columbianadin has analgesic, anti-inflammatory, calcium-channel blocking, and platelet aggregation inhibiting functions. It can effectively suppress the growth of colon cancer cells, the induction of apoptosis was correlated with the modulation of caspase-9, caspase-3, Bax, Bcl-2, RIP-3, and caspase-8, Bim and Bid. |
| CFN99786 | Anemoside B4 1. Anemoside B4(AB4) and tetrandrine(Tet) have some reversal effect on resistant to L-OHP in Lo Vo/L-OHP cells, the molecular mechanism of the resistance reverse effect was related to down-regulation of P-gp for AB4 and down-regulation of z DHHC9 for Tet. 2. Anemoside B4 can inhibit the production of IL-6,secretion of IL-8, downregulate E-selectin expression, and decrease the content of TXB(2), it reduces inflammatory response, thus relieving intestinal dysfunction via multiple pathways. 3. Anemoside B4 may potentially have a capacity to regulate immune responses in vivo via changes in production of these select cytokines by infected endothelial cells. |
| CFN99787 | Lysionotin Lysionotin is a natural flavonoid predominantly found in fewflower lysionotus herbs and possesses many pharmacological properties, such as antibacterial, anti-inflammatory, antihypertensive, and free radical scavenging activities. It is an efficient inhibitor of α-toxin expression and shows significant protection against S. aureus in vitro and in vivo. |
| CFN99788 | Irisflorentin Irisflorentin has anti-inflammatory activity, it can markedly reduce the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO, it also can significantly inhibit TNF-α, IL-1βand IL-6 at both the transcriptional and translational levels; Irisflorentin has potential to ameliorate Parkinson’s disease in Caenorhabditis elegans models by promoting rpn-3 expression and down-regulating egl-1 expression; Irisflorentin may as an immunotherapeutic adjuvant. |
| CFN99789 | (-)-Bilobalide Bilobalide possesses anticonvulsant, insecticidal, and cardioprotective effects. Bilobalide exerts protective and trophic effects on neurons, the PI3K/Akt pathway may be involved in the protective effects of bilobalide; it also can protect PC12 cells from A beta 25-35-induced cytotoxicity, it dose-dependently attenuates the cytotoxic effect of A beta 25-35. |
| CFN99790 | Cantharidin Cantharidin, a natural toxicant of blister beetles, is a strong inhibitor of protein phosphatases types 1 (PP1) and 2A (PP2A), and is a novel and potent multidrug resistance (MDR) reversal agent. Cantharidin has anti-tumor activity, it causes oxidative stress that provokes DNA damage and p53-dependent apoptosis, it impairs cell migration and invasion by suppressing MMP-2 and -9 through PI3K/NF-κB signaling pathways. |
| CFN99821 | 22-Hydroxy-3-oxo-12-ursen-30-oic acid Reference standards. |
| CFN99822 | Dehydroabietic acid Dehydroabietic acid , a major poison to fishes in pulp and paper mill effluents, which could be useful in improving the diabetic wound healing, it can reverse several cell responses stimulated by TNF-α, including the activation of FOXO1 and the TGF-β1/Smad3 signaling pathway. Dehydroabietic acid derivatives displays antisecretory and antipepsin effect, have gastroprotective activity in the HCl/EtOH-induced gastric lesions in mice as well as for cytotoxicity in human lung fibroblasts (MRC-5) and human epithelial gastric (AGS) cells. |
| CFN99823 | Methyl 3-(2,4-dihydroxyphenyl)propionate Methyl 3-(2,4-dihydroxyphenyl)propionate has inhibitory effects on tyrosinase, antioxidant ability, and lightening effect of ultraviolet B (UVB)-induced hyperpigmentation. |
| CFN99824 | alpha-Spinasterol glucoside |
| CFN99825 | Carabrone Some of carabrone derivatives exhibit antifungal activities in vitro or in vivo, the compounds with a pyridinyl residue can either efficiently inhibit spore germination or efficiently inhibit hyphal growth of B. cinerea. |
| CFN99826 | Xanthorin Xanthorin has anticomplementary activity. |
| CFN99827 | Longifloroside A Longifloroside A is a natural product from Ligustrum lucidum. |
| CFN99828 | Nervogenic acid Nervogenic acid has antioxidative, pro-coagulant, and antibacterial activities, it exhibits higher activity than that of t-butyl-4- hydroxyanisole (BHA) using the ferric thiocyanate method. |
| CFN99829 | Dihydropinosylvin methyl ether Reference standards. |
| CFN99830 | Nicotiflorin Nicotiflorin shows potent antiglycation activity and neuroprotection effects, it has protective effects on cerebral ischemic damage, reducing memory dysfunction, energy metabolism failure and oxidative stress in multi-infarct dementia model rats. |
| CFN99831 | 8-Hydroxyodoroside A An antitumor agent containing at least one compound selected from the group consisting of nerigoside, oleandrigenin, sarmentoside, oleaside A, oleandrin, 8β-hydroxy odoroside A, narciclasine, trans-dihydronarciclasine and bisdeoxynarciclasine is provided, this antitumor agent has an advantage of having an excellent therapeutic effect of tumor and less side effects. |
| CFN99832 | Scutebarbatine A Scutebarbatine A shows significant antitumor effects on A549 cells in vivo and in vitro via mitochondria-mediated apoptosis by up-regulating expressions of caspase-3 and 9, and down-regulating Bcl-2. Scutebarbatine A and barbatine A show a significant ability to protect cells against H2O2 with ED50 values of 5.0 and 16.8 uM, respectively. |
| CFN99833 | Ducheside A Ducheside A is a natural product from Diplopanax stachyanthus. |
| CFN99834 | trans-Hinokiresinol Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphylaxis reaction. Hinokiresinol (trans-hinokiresinol) and nyasol (cis-hinokiresinol) are estrogen agonists, they possess appreciable estrogen receptor binding activity, they can stimulate the proliferation of estrogen- dependent T47D breast cancer cells, and their stimulatory effects could be blocked by an estrogen antagonist. They have similar free radical scavenging and anti-inflammatory activities, they also have anti-ischemic effects, only trans-hinokiresinol can significantly decrease neuronal injury in cultured cortical neurons exposed to oxygen-glucose deprivation followed by re-oxygenation. |
| CFN99835 | Glycerol 1-(26-hydroxyhexacosanoate) Reference standards. |
| CFN99791 | Norcantharidin Norcantharidin has been used to treat human cancers in China since 1984, it inhibits the canonical Wnt signal pathway in NSCLC, by activating WIF-1 via promoter demethylation; it also enhances TIMP‑2 antitumor and anti‑vasculogenic mimicry activities in GBCs through downregulating MMP‑2 and MT1‑MMP. Norcantharidin is a protein phosphatase type-2A inhibitor, which has less nephrotoxic and phlogogenic side-effects, it can inhibit both DNA synthesis and granulocyte-macrophage colony-forming cells (GM-CFC)growth and impaire the neogenesis of chromatin material and nuclear membrane during the M/G1 phase transition in K-562 cells. |
| CFN99792 | Phytic acid Phytic acid is the principal storage form of phosphorus in many plant tissues, especially bran and seeds. It can act as a cofactor in DNA repair by nonhomologous end-joining. It is a trypsin inhibitor, has chelating, antioxidant, anti-inflammatory, and neuroprotective effects, it forms an iron chelate which greatly accelerates Fe2+-mediated oxygen reduction yet blocks iron-driven hydroxyl radical generation and suppresses lipid peroxidation. High concentrations of phytic acid prevent browning and putrefaction of various fruits and vegetables by inhibiting polyphenol oxidase, it may be a substitute for presently employed preservatives. |
| CFN99793 | Phytic acid sodium salt hydrate Phytic acid sodium salt has inhibitory effect on the activity of the digestive protease and α‐amylase in rohu, Labeo rohita, catla, Catla catla, and mrigal, Cirrhinus mrigala . The sodium salt of phytic acid may have a role in both the prevention and treatment of many forms of cancer. |
| CFN99794 | Humic acid sodium salt Sodium salt of humic acid and sodium silicate have similar enhancement on kerosene contaminated soil washing with saponin. |
| CFN99795 | Phytin 1. Phytin and magnesium citrate have hypocalciuric effect , they can reduce urinary calcium excretion in rats fed on high-calcium diets. 2. A six-day treatment with phytin can restore the normal level of the liver monooxygenase system components and MMW peptides, also can reduce the level of lactic acid (LA) and increased that of pyruvic acid (PA) in liver tissues, which lead to a sharp drop in the LA/MA ratio indicative of a decrease in the extent of hypoxia. 3. Individually phytin, EDTA and copper (Cu2+) have inhibitory effect on growth of Gram positive as well as Gram negative bacteria, phytin preferentially protects only Gram negative bacteria from Cu 2+ ion toxicity,phytin also has chelating ability. |
| CFN99796 | Cholic acid Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. It prevents hepatic TG accumulation, VLDL secretion, and elevated serum TG in mouse models of hypertriglyceridemia;at the molecular level, CA decreases hepatic expression of SREBP-1c and its lipogenic target genes. |
| CFN99797 | Hyodeoxycholic acid Hyodeoxycholic acid is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC50 of 31.6 µM in CHO cells. Hyodeoxycholic acid has hypolipidemic effect through regulation of FXR activation, it is a candidate for antiatherosclerotic drug, by significantly increasing the expression of genes involved in cholesterol efflux, such as Abca1, Abcg1,and Apoe,in a macrophage cell line. |
| CFN99798 | Deoxycholic acid Deoxycholic acid is a strong promoter of hepatocarcinogenesis with possible complete carcinogenicity in the liver and promotion potential for tumor development in the small intestine. Loss of deoxycholic acid-induced EGFR/Ras/MAPK pathway function potentiates deoxycholic acid-stimulated FAS-induced hepatocyte cell death via a reduction in the expression of c-FLIP isoforms. |
| CFN99799 | Sesamolin Sesaminol possesses antioxidative activity, can inhibit lipid peroxidation in rat liver and kidney. It also shows neuroprotection effect on hypoxic neuronal and PC12 cells through the suppression of ROS generation and MAPK activation. |
| CFN99800 | Levodopa Levodopa is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), used to treat Parkinson's symptoms. |
| CFN99901 | Hordenine Hordenine is an inhibitor of noradrenaline uptake, is also an effective inhibitor of hyperpigmentation. It can inhibit melanogenesis by suppressing cAMP production, which is involved in the expression of melanogenesis-related proteins. Hordenine also has a positive inotropic effect upon the heart, increases systolic and diastolic blood pressure, peripheral blood flow volume, inhibits gut movements. |
| CFN99902 | Honokiol Honokiol has antibacterial, anti-angiogenesis, antidepressant-like, antioxidant, anti-inflammatory and anti-cancer effects. It inhibited the activation of Akt and enhances the phosphorylation of ERK1/ERK2. It can improve learning, memory impairments and neuroinflammatory processes induced by SCOP in mice, by inhibition of AChE activity. |
| CFN99836 | Hardwickiic acid Hardwickiic acid modulates hippocampal [(3)H]NA overflow evoked by a mild depolarizing stimulus by acting at presynaptic opioid receptor subtypes. Hardwickiic acid shows antimicrobial activity, it can inhibit the growth of all the tested microbial species. (-)-Hardwickiic acid has insecticidal activity. |
| CFN99837 | Linderone Linderone A shows anticancer activity against A549 non-small cell lung cancer cells and PC-3 prostate adenocarcinoma cell line. |
| CFN99838 | Oleoside Oleacein is a strong Angiotensin Converting Enzyme (ACE)-inhibitor (IC50 = 26 uM). |
| CFN99839 | Myricadiol Myricadiol is a potential lead compound for synthetic anti-cancer drugs. |
| CFN99840 | Myricitrin Myricitrin exhibits hepatoprotective, anti-inflammatory,antioxidant, anti-allergic, antinociception, anxiolytic-like, and antipsychotic-like effects. Myricitrin can be used as a drug candidate for the treatment of cardiovascular diseases, by effectively protecting cells from ox-LDL-induced endothelial cell apoptosis and reducing atherosclerotic plaque formation. Myricitrin is also a nitric oxide (NO) and protein kinase C (PKC) inhibitor that has central nervous system activity. |
| CFN99841 | Macrocarpal H Macrocarpal H has anti-glucosyltransferase, and anti-bacterial activities. |
| CFN99842 | Macrocarpal I Macrocarpal I has anti-glucosyltransferase, and anti-bacterial activities. |
| CFN99843 | Macrocarpal J Macrocarpal J has anti-bacterial activity, it also has anti-glucosyltransferase activity. |
| CFN99844 | Phytolaccagenin Phytolaccagenin has promising antifungal activity against ATCC standard cultures of Candida albicans and Cryptococcus neoformans, and against clinical isolates of these fungi, it also shows inhibitory effects on lipopolysaccharide-induced NO production, and haemolytic activities. |
| CFN99845 | Spiramilactone B Reference standards. |
| CFN99846 | 5-Hydroxy-4-methoxycanthin-6-one 4-Methoxy-5- hydroxycanthin-6-one has anti-inflammatory effect, it can significantly inhibit the production of NO and the release of TNF-α induced by LPS in macrophage RAW 264.7, it has protective effect on dextran sulfate sodium -induced rat colitis. After oral administration, 4-methoxy-5- hydroxycanthin-6-one (3, 9, and 27 mg/kg) can reduce the development of carrageenan-induced paw edema and complete Freund's adjuvant (CFA)-induced chronic arthritis in rats. 5-Hydroxy-4-methoxycanthin-6-one exhibits significant cytotoxic activity against CNE2 cell line. |
| CFN99847 | 4,5-Dimethoxycanthin-6-one 4,5-Dimethoxycanthin-6-one has antibacterial actiyity, it exhibits inhibition against Staphylococcus aureus and its drug-resistant strains. 4,5-Dimethoxycanthin-6-one has a strong inhibitory effect on cyclic adenosine monophosphate (cAMP) phosphodiesterase. It also shows cytotoxicity against the tumor cell lines, U937 and HepG2. |
| CFN99848 | Naringenin-4',7-diacetate Reference standards. |
