Natural Products
| Catalog No. | Information |
| CFN99875 | 3'-Hydroxyrocaglamide 3'-Hydroxyrocaglamide has insecticidal activity. |
| CFN99927 | Crocin I Crocin has antihyperlipidemic, antidepressant, anti-inflammatory and anti-apoptotic effects, it has a wide spectrum of targets including iNOS, caspase, CREB, BDNF and VGF. |
| CFN99928 | Crocin II Crocin has antihyperlipidemic, antidepressant , anti-inflammatory and anti-apoptotic effects. It can reduce the protein expression of iNOS and caspase-3, and increase CREB, BDNF and VGF levels in hippocampus. |
| CFN99929 | Morin Morin, a α-glucosidase inhibitor with an IC50 value of (4.48 ± 0.04) uM, it also exhibits inhibition in the generation of advanced glycation end products which was related to the long term complications of diabetes. Morin has anti-inflammatory and anti-oxidative effects by activating Nrf2 signal pathways and inhibiting NF-κB activation. it can be used to prevent bladder cancer, it prevents MMP-9 expression via the inhibition of transcription factors AP-1, Sp-1, and NF-κB. |
| CFN99930 | D-(-)-Quinic acid D-(-)-Quinic acid is a cellular metal ion chelator, capable of promoting reactions with metal M(II,III) ions under pH-specific conditions. It may possess potent inhibition against alpha-mannosidase and alpha-fucosidase. |
| CFN99876 | 3'-Methoxyrocaglamide C-3'-Methoxyrocaglamide has insecticidal activity. |
| CFN99877 | Corchoionol C Reference standards. |
| CFN99878 | Pinostrobin chalcone Pinostrobin chalcone is a potent inhibitor of triglyceride accumulation, it can inhibit adipogenesis in 3T3-L1 cells, it may have anti-obesity effects through the inhibition of adipogenesis. Pinostrobin chalcone displays very remarkable cytotoxic activity against the human cancer cells, such as KB, MCF7 and Caski cells (IC50 values of 6.2, 7.3 and 7.7 ug/mL, respectively). |
| CFN99879 | Eupatoriochromene Eupatoriochromene retard seed germination , reduced radicle and hypocotyl growth of weed and crop plant seedlings and increased adventitious root formation of mung bean cuttings. Eupatoriochromene has insecticidal activity, it exhibits toxicity againstCulex pipiens (house mosquito) larvae andOncopeltus fasciatus (large milkweed bug) nymphs. |
| CFN99880 | Demethoxyencecalin Reference standards. |
| CFN99881 | Triptocallic acid A Reference standards. |
| CFN99882 | Isocupressic acid Isocupressic acid induces abortion in pregnant cows when ingested primarily during the last trimester, it decrease affects the angiogenesis of the female reproductive system, the decrease in blood flow and apoptosis of corpus luteum-derived endothelial cells of the uterine tissue results in abortion. Isocupressic acid shows strong inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) induction (100 % inhibition at 1000 mol ratio/12-O-tetradecanoylphorbol 13-acetate (TPA). |
| CFN99883 | Salvigenin Salvigenin, a potent hMAO-A [monoamine oxidases (MAOs)]inhibitor, has neuroprotective, antitumor and immunomodulatory effects, it has potential to ameliorate Streptozotocin-induced diabetes mellitus and heart complications in rats. Salvigenin has dose-dependent analgesic effect so that it can be useful in controlling of inflammations, acute and chronic pain. |
| CFN99931 | 6-Gingerol 6-Gingerol possesses anti-adipogenic, anti-tumorigenic, anti-invasive, antioxidant, anti-inflammatory, and pro-apoptotic activities, it stimulates apoptosis through upregulation of NAG-1 and G1 cell cycle arrest through downregulation of cyclin D1, multiple mechanisms appear to be involved in 6-gingerol action, including protein degradation as well as β-catenin, PKCε, and GSK-3β pathways. 6-Gingerol can effectively suppress adipogenesis and that it exerts its role mainly through the significant down-regulation of PPARγ and C/EBPα and subsequently inhibits FAS and aP2 expression, also inhibit differentiation in 3T3-L1 cells by attenuating the Akt/GSK3β pathway. |
| CFN99932 | Ligustilide Ligustilide possesses neuroprotective, vasorelaxation, antinociceptive and anti-inflammatory activities, it blocked the activation of MAPKs/IKK and the downstream transcription factors AP-1 and NF-κB. It has the potential to be developed into an effective drug for the treatment of various pain syndromes including primary dysmenorrhoea. |
| CFN99933 | 1-Deoxynojirimycin 1-Deoxynojirimycin is a potent α-glucosidase inhibitor, suppresses postprandial blood glucose, thereby possibly preventing diabetes mellitus. 1-Deoxynojirimycin as a therapeutic agent by controlling the overgrowth and biofilm formation of S. mutans, it also can block human immunodeficiency virus envelope glycoprotein- mediated membrane fusion at the CXCR4 binding step. |
| CFN99934 | Alantolactone Alantolactone, an allergenic sesquiterpene lactone, has significant antitumor effects on malignant tumor cells, it can suppress inducible nitric oxide synthase and cyclooxygenase-2 expression by down-regulating NF-κB, MAPK and AP-1 via the MyD88 signaling pathway in LPS-activated RAW 264.7 cells, and inhibit cell proliferation by interrupting the interaction between Cripto-1 and activin receptor type II A in activin signaling pathway. |
| CFN99935 | Nomilin Nomilin has immunomodulatory, antioxidant, anti-human immunodeficiency virus(HIV), cancer chemopreventive, antiangiogenic, anti-obesity and anti-hyperglycemic effects. Nomilin inhibits tumor-specific angiogenesis by downregulating VEGF, NO and proinflammatory cytokine profile and also by inhibiting the activation of MMP-2 and MMP-9. It inhibits osteoclastogenesis in vitro by suppression of NFATc1 and MAPK signaling pathways, indicates that nomilin-containing herbal preparations have potential utility for the prevention of bone metabolic diseases. |
| CFN99936 | Tetrodotoxin Tetrodotoxin, a poison from the puffer fish, at very low concentrations, blocks the action potential production through its selective inhibition of the sodium-carrying mechanism while keeping the potassium-carrying mechanism intact.Modulation of tetrodotoxin-resistant voltage-gated Na+ current (TTX-R INa) is a mechanism for sensitization of mammalian nociceptors. |
| CFN99937 | Mogroside V Mogroside V is a widely used sweetener, has in vitro AMPK activating effect, it also has anti-inflammatory potential in murine macrophages and a murine ear edema model, and has the potential to protect against LPS-induced airway inflammation in a model of ALI. |
| CFN99938 | Punicalagin Punicalagin has antifungal , antiviral, anti-atherosclerotic, hepatoprotective , anti-obesity., antiproliferative, anti-apoptotic, anti-inflammatory, and antioxidant effects. It can suppress the phosphorylation of MAPK including p38, c-JNK, and ERK, it also has potently inhibiting the activity of fatty acid synthase with half-inhibitory concentration values (IC 50 ) of 4.50μM. |
| CFN99939 | Epimedin A Epimedin A,epimendin B, epimendin C, icariin and baohuoside are flavonoids, main active ingredient in Epimedium, have clear anti-osteoporosis effect, the accumulation of epimedins A, B, C, and icariin in a traditional medicinal plant could be suppressed by light stress. |
| CFN99940 | Epimedin B Epimedin A,epimendin B, epimendin C, icariin and baohuoside are flavonoids, main active ingredient in Epimedium, have clear anti-osteoporosis effect, the accumulation of epimedins A, B, C, and icariin in a traditional medicinal plant could be suppressed by light stress. |
| CFN99884 | Oplopanone Oplopanone exhibits noteworthy anti-plasmodial activity against Plasmodium falciparum strain. |
| CFN99885 | 6-Deoxy-3-O-methyl-beta-allopyranosyl(1-4)-beta-cymaronic acid delta-lactone Reference standards. |
| CFN99886 | Epieriocalyxin A Epieriocalyxin A can suppress Caco-2 colon cancer cell growth, it could be a potential drug for colon cancer therapy in the future. |
| CFN99887 | 2-Deacetoxytaxinine B 2-Deacetoxytaxinine B is a strongly inhibitor against U46619-induced aggregation, it shows strong inhibitory effects against arachidonic acid (AA)-induced aggregation. |
| CFN99888 | Deoxypodophyllotoxin Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflammatory activities. Deoxypodophyllotoxin induces G2 /M cell-cycle arrest followed by apoptosis through multiple cellular processes, involving the activation of ATM, upregulation of p53 and Bax, activation of caspase-3 and -7, and accumulation of PTEN resulting in the inhibition of the Akt pathway. Deoxypodophyllotoxin maybe applicable to treat hyperpigmentation, it decreases UV-induced skin pigmentation of brown guinea pigs. |
| CFN99889 | Ergosta-4,6,8(14),22-tetraen-3-one Ergosta-4,6,8(14),22-tetraen-3-one has cytotoxic activity against human gastric cancer cell, it can induce G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells, these results would be useful for the further utilization of many medicinal fungi in cancer treatment. Ergosta-4,6,8(14),22-tetraen-3-one treatment can confer protection against early renal injury in a rat model of aristolochic acid (AA) nephropathy, early administration of it may prevent the progression of renal injury and the subsequent renal fibrosis in AA nephropathy. It has inhibitory activity of nitric oxide production in RAW 264.7 cells stimulated by lipopolysaccharide was examined and shows a potential activity with the IC(50) value of 28.96 microM. |
| CFN99890 | Cardamonin Cardamonin is a naturally occurring chalcone with strong anti-inflammatory , anticancer, anti-melanogenesis, and vascular activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-kB inhibitor. It ameliorates insulin resistance induced by high insulin and high glucose through the mTOR and signal pathway. It also may be a potential whitening agent for use in cosmetics and in the medical treatment of hyperpigmentation disorders. |
| CFN99891 | 10-O-Vanilloylaucubin 10-O-Vanilloylaucubin shows significant writhing inhibition following oral administration at doses of 25 mg/kg.suggests that it has analgesic effects. |
| CFN99892 | 6,19-Dihydroxyurs-12-en-3-oxo-28-oic acid Reference standards. |
| CFN99893 | Rivulobirin B Rivulobirin B is a natural product from Heracleum rapula Franch. |
| CFN99894 | Isohyenanchin Isohyenanchin is the potent antagonist of RDLac homo-oligomers, it is also a weak antagonist of ionotropic GABA receptors. |
| CFN99895 | 4-Hydroxycinnamamide 4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases. |
| CFN99896 | Alphitolic acid Alphitolic acid is a potent Hh/GLI signaling inhibitor, it shows an important relationship between Hh/GLI signaling inhibition, the decrease of BCL2, and cytotoxicity against cancer cells. Alphitolic acid has anti-inflammatory, antitumour, and antimicrobial activities, it can suppress the proliferation of SCC4 and SCC2095 OSCC cells with IC50 values of 12 and 15 uM, respectively, via apoptotic induction, this drug effect on apoptosis is, in part, associated with its ability to block Akt-NF-κB signalling; it could as an ingredient in functional food/dietary supplement for OSCC prevention. |
| CFN99897 | 2,16,19-Kauranetriol 2-O-beta-D-allopyranoside Reference standards. |
| CFN99898 | 2,6,16-Kauranetriol 2-O-beta-D-allopyranoside Reference standards. |
| CFN99899 | Indole-3-acrylic acid methyl ester Reference standards. |
| CFN99900 | 7,4-Di-O-methylapigenin 5-O-glucoside Reference standards. |
| CFN98000 | Stigmasterol glucoside Stigmasterol glucoside, a constituent of Adenanthera pavonina seed and leaf, may be a plant anticancer agent. |
| CFN98001 | Pseudopalmatine Pseudopalmatine exhibits antiplasmodial activity. It also shows anti-acetylcholinesterase (AChE) activity, with IC50 values of 1.8uM. |
| CFN98002 | 11-Dehydroxygrevilloside B Reference standards. |
| CFN98003 | Daphmacrine Reference standards. |
| CFN98004 | Erythrodiol 3-palmitate Erythrodiol 3-palmitate has antitumor activity, it inhibited the proliferation of K562 cells with the inhibition rate of 47% at 100 ug/mL. |
| CFN98005 | Cabralealactone Cabralealactone displays antimycobacterial activity against Mycobacterium tuberculosis, it is weakly cytotoxic to a breast cancer (BC) cell line, it is moderately active against a small-cell lung cancer (NCI-H187) cell line. |
| CFN99942 | Picfeltarraenin IA Picfeltarraenin IA has anti-inflammatory activity, it is a strong AChE inhibitior, and an potential PI3K and epidermal growth factor receptor (EGFR ) inhibitor. It acts as an inhibitor on both the classical and alternative pathways of the complement system. |
| CFN99943 | Aloin A Plants containing aloin A, aloe emodin, and structurally related anthraquinones have long been used as traditional medicines and in the formulation of retail products such as laxatives, dietary supplements, and cosmetics; however, topically applied aloe emodin increases the sensitivity of skin to UV light, although aloin A is not directly photocytotoxic, but human skin fibroblasts can metabolize aloin A to aloe emodin. Aloin A and aloe emodin have antibacterial activity against Gram-positive and Gram-negative bacteria. |
| CFN99944 | Atractylenolide I Atractylenolide I, a TLR4-antagonizing agent, shows a wide spectrum of pharmacological activities such as anti-inflammatory, digestion promoting,significant antitumor, and antioxidant effects. It ameliorates sepsis syndrome,liver and kidney functions by reduction of pro-inflammatory cytokines and LPS. |
| CFN99945 | Atractylenolide II Atractylenolide II has antiinflammatory activity, it can inhibit platelets activities and thrombus formation. Atractylenolide II has cytotoxic/apoptotic effects may via p38 activation ,ERK and Akt inactivation, p53 dependent, it also has antimelanoma effect by inhibiting STAT3 signalling. |
