Natural Products
| Catalog No. | Information |
| CFN98129 | Dauricine Dauricine may has neuroprotective, and anti-tumor effects, it can pass the blood‑brain barrier, and that P‑glycoprotein has an important role in the transportation of Dauricine across the blood‑brain barrier, it can inhibit tumor cells in urinary system and colon cancer cell proliferation, invasion; induce cell apoptosis by suppressing NF-kappaB activity and the expression profile of its downstream genes. Dauricine also has pulmonary toxicity, can produce pulmonary injury in CD-1 mice by the metabolism of Dauricine mediated by CYP3A. |
| CFN98130 | Strychnine Strychnine-insensitive glycine site NMDA antagonist ( R )-HA-966 have neuroprotective effects in an experimental model of Parkinson's disease. Strychnine insensitive glycine receptor has anticonvulsant properties.Strychnine can block binaural inhibition in lateral superior olivary neurons, decrease the voltage-dependent Ca2+ current of both Aplysia and frog ganglion neurons. Strychnine also has inhibitory effects on GABA- and glycine-induced responses. |
| CFN98273 | 1,2:4,5-Di-O-isopropylidene-beta-D-fructopyranose 1,2:4,5-di-O-isopropylidene-beta-D-fructopyranose is a synthetic precursor of the asymmetric epoxidation catalyst 1,2:4,5-di-O-isopropylidene-beta-D-erythro-2,3- hexadiulo-2,6-pyranose. |
| CFN98274 | Excavatin M Reference standards. |
| CFN98275 | Crebanine Crebanine has antiarrhythmic, anticancer, anti-inflammatory, and analgesic properties; it can significantly improve the cognitive deficits induced by scopolamine, via the alpha-7 nicotinic acetylcholine receptor, crebanine or its scaffold can be used as the starting point to develop a drug for Alzheimer's disease.Crebanine can reduce TNF-α-induced cancer cell proliferation, invasion, and survival by suppressing NF-κB activity and expression profile of its downstream genes. |
| CFN98276 | 9,9'-O-Isopropyllidene-isolariciresinol Reference standards. |
| CFN98277 | 20S,24R-Epoxydammar-12,25-diol-3-one Reference standards. |
| CFN98278 | Isocalamendiol Standard reference |
| CFN98279 | Litseglutine B Reference standards. |
| CFN98280 | (+)-Afzelechin (+)-Afzelechin has a neuroprotective effect on the glutamate-induced neurotoxicity in HT22 cells, it has ABTS cation radical scavenging effects with IC50 values of 23.7 microM; it also shows moderate to strong radical scavenging properties against diphenylpicrylhydrazyl radical (DPPH) and improves the reduced glutathione levels in rat pancreatic homogenate.(+)-Afzelechin has inhibitory compound of alpha-glucosidase activity, the ID(50) (50% inhibition dose) value is 0.13 mM. |
| CFN98281 | 2,3-Bis(3,4-dimethoxybenzyl)butyrolactone trans-2,3-Bis(3,4-dimethoxybenzyl)-gamma-butyrolactone is capable of inhibiting Na+,K+-ATPase activity with IC50 at a concentration less than 5 x 10(-4) M, it also shows [3H]ouabain displacement activity with IC50 at a concentration of 10(-4)-10(-3) M. |
| CFN98282 | Isoferulic acid Isoferulic acid is an effective natural antioxidant in both lipid and aqueous media, it may be a new promising anti-glycation agent for the prevention of diabetic complications via inhibition of advanced glycation end products (AGEs) formation and oxidation-dependent protein damage. Isoferulic acid is a novel and potent inhibitor of murine IL-8 production, it also has inhibitory effect on mushroom tyrosinase. |
| CFN98283 | Mayumbine Mayumbine (IC50 = 76 ± 3.5 nM) potently inhibit the in vitro binding of 3H-diazepam to the benzodiazepine sites within the rat GABAA receptor complex. |
| CFN98284 | 1,6,7-Trihydroxyxanthone 1,6,7-Trihydroxyxanthone has anti-cancer activity ,at least in part, through the activation of miR-218 and suppression of Bmi-1 expression; can suppress cell growth and induce apoptosis in liver cancer cells. |
| CFN98285 | Schleicheol 2 Reference standards. |
| CFN98286 | Preisocalamendiol Preisocalamendiol, a plausible precursor of isocalamendiol. |
| CFN98287 | Cannabigerol Cannabigerol is a high affinity α2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also binds to the CB2 receptor; it can relieve interocular pressure, which may be of benefit in the treatment of glaucoma. Cannabigerol has antimicrobial and antifungal activity, It exhibits the highest growth-inhibitory activity against the cancer cell lines. Cannabigerol is also a novel, well-tolerated appetite stimulant in pre-satiated rats. |
| CFN98288 | Cimiracemoside C The Cimicifuga racemosa extract Ze 450 and some of its components (23-epi-26-deoxyactein, protopine and cimiracemoside C) can reduce significantly body weight, plasma glucose, improve glucose metabolism and insulin sensitivity in diabetic ob/ob mice; suggests that part of the effects may be related to AMPK activation.Ze 450 may have utility in the treatment of type 2 diabetes. |
| CFN98289 | Tutin Tutin in honey, is a plant-derived neurotoxin. |
| CFN98290 | Velutin Velutin has strong anti-inflammatory activity, it can effectively inhibit the expression of proinflammatory cytokines TNF-α and IL-6 in low micromole levels by inhibiting NF-κB activation and p38 and JNK phosphorylation. Velutin controls HIF-1α activity during PgLPS-activated osteoclastogenesis probably through modulation of the NF-κB pathway, perhaps it could be used therapeutically to prevent bone loss seen in periodontitis.Velutin can induce apoptosis in tumor cells. |
| CFN98291 | 5-Hydroxy-7-methoxy-3-(4-hydroxybenzylidene)chroman-4-one Reference standards. |
| CFN98292 | Zamanic acid Standard reference |
| CFN98131 | Rhynchophylline Rhynchophylline, a noncompetitive antagonist of the NMDA receptor, which has anti-inflammatory, anti-hypertension, cardiacprotective and neuroprotective activities. Rhynchophylline can markedly inhibit rabbit platelet aggregation induced by ADP or thrombin possibly by depressing the inflow of Ca2+ and the rise of the cytoplasmic free calcium level in platelet.Rhynchophylline can reduce the systolic blood pressure (SBP) of spontaneously hypertensive rats (SHR) significantly, decrease plasma Ang II, ADMA, and AT1R levels, and promote serum NO and NOS levels, which has the protection of vascular endothelial function. |
| CFN98132 | Isorhynchophyllic acid Isorhynchophyllic acid can significantly inhibit the proliferation of human cancer cells(A549, HepG2 and A2780 cells) with IC50 values being 5.8, 12.8 and 11.8 umol/L, respectively. |
| CFN98133 | Germacrone Germacrone has anti-tumor activity, it can inhibit the proliferation of breast cancer cell lines by inducing cell cycle arrest and apoptosis through mitochondria-mediated caspase pathway. Germacrone shows antiviral activity against the H1N1 and H3N2 influenza A viruses and the influenza B virus in a dose-dependent manner, exerts an effective protection of mice from lethal infection and reduces the virus titres in the lung. Germacrone also moderately inhibits CYP2B6 and CYP3A4 activities in vitro, with IC50 values below 10 uM, and produces two oxidized metabolites and four glutathione conjugates. |
| CFN98134 | Platycodin D Platycodon D shows antinociceptive, and anti-inflammatory activities, it can induce autophagy in NCI-H460 and A549 cells through inhibiting PI3K/Akt/mTOR signaling pathway and activating JNK and p38 MAPK signaling pathways. Platycodon D can inhibit migration, invasion, and growth of MDA-MB-231 human breast cancer cells via suppression of EGFR-mediated Akt and MAPK pathways. Platycodin D is also a potent adjuvant of specific cellular and humoral immune responses against recombinant hepatitis B antigen. |
| CFN98135 | Crotaline Crotaline venoms produce various toxic effects, although these are most commonly treated with specific antivenoms. Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid (PA) that causes a pulmonary vascular syndrome in rats characterized by proliferative pulmonary vasculitis, pulmonary hypertension, and cor pulmonale. |
| CFN98136 | Orientin Orientin has various activities including anti-oxidant, anti-aging, anti-viral, anti-bacterial, anti-inflammation, vasodilatation and cardioprotective, antiadipogenesis, antinociceptive, radiation protective, neuroprotective, and antidepressant-like effects. Orientin protects H9c2 cardio-mytocytes against I/R-induced apoptosis by modulating the mPTP opening, and this role of orientin may involve the PI3K/Akt signaling pathway; it also can decrease C/EBPα and PPARγ protein expression level in 3T3-L1 cells. |
| CFN98137 | Luteolin-6-C-glucoside Luteolin-6-C-glucoside has antioxidant activity. |
| CFN98138 | Tuberostemonine Tuberostemonine has antitussive activity, acts in part as an open-channel blocker at the crayfish neuromuscular junction; it also exhibits relatively higher intestinal permeabilities. |
| CFN98139 | Praeruptorin A Praeruptorin A exerts neuroprotective, anti-osteoclastogenic, anti-inflammatory, distinct relaxant effects, it is beneficial to facilitate nestin expression in myocarditis,and suitable in treatment of early myocarditis. Praeruptorin A can significantly up-regulate UGT1A1 expression in HepG2 cells partially via the CAR-mediated pathway. Praeruptorin A inhibited p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca2+ oscillation. |
| CFN98140 | Praeruptorin B Praeruptorin B has significant important phase II drug-metabolizing enzymes uridine 5'-diphospho-glucuronosyltransferase (UGTs) isoforms inhibition activity. Praeruptorin B and praeruptorin A have LC 50 values of 34.5 and121.2 ug/ml, respectively, in Artemia salina test . |
| CFN98293 | Dihydroisotanshinone II Reference standards. |
| CFN98294 | 1-Isomangostin hydrate Reference standards. |
| CFN98295 | 3-Isomangostin hydrate Reference standards. |
| CFN98296 | Reneilmol Reference standards. |
| CFN98297 | Picrasin B Picrasin B shows a significant clastogenic activity in cell cultures of Don lung cells of Chinese hamster. |
| CFN98298 | Antiarol rutinoside Reference standards. |
| CFN98299 | 3,19-Dihydroxy-6,23-dioxo-12-ursen-28-oic acid Reference standards. |
| CFN98300 | Foliamenthoic acid Foliamenthoic acid shows α-glucosidase inhibition. |
| CFN98301 | 7,15-Dihydroxypodocarp-8(14)-en-13-one Reference standards. |
| CFN98302 | 2,3',4,6-Tetrahydroxybenzophenone 2,3',4,6-Tetrahydroxybenzophenone possesses significant antioxidant activity. |
| CFN98303 | Ficaprenol 11 Standard reference |
| CFN98304 | 22-Dehydroclerosterol 22-Dehydroclerosterol has antibacterial activity against against E. coli, S. aureus, and H. pylori. |
| CFN98305 | 3,27-Dihydroxy-20(29)-lupen-28-oic acid methyl ester 3α, 27-Dihydroxylupen-20(29)-en-28-oic acid methyl ester is a potent topoisomerase II inhibitor. |
| CFN98306 | 3-Acetoxy-27-hydroxy-20(29)-lupen-28-oic acid methyl ester 3α, 27-Dihydroxylupen-20(29)-en-28-oic acid methyl ester is a potent topoisomerase II inhibitor. |
| CFN98307 | 6',7'-Dihydroxybergamottin 6',7'-Dihydroxybergamottin(DHB), a well-known inhibitor of CYP3A4, the inhibition of CYP3A4 activity by DHB includes the inhibition of POR activity, DHB can inhibit nifedipine oxidation in a concentration-dependent manner. |
| CFN98308 | Clovanediol Reference standards. |
| CFN98309 | Clovanediol diacetate Reference standards. |
| CFN98310 | 2,3-Dihydroxy-12-oleanen-28-oic acid 2,3-Dihydroxy-olean-12-en-28-oic acids show a low cytotoxicity towards several human tumor cell lines. |
